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    Nrdc nardilysin convertase [ Mus musculus (house mouse) ]

    Gene ID: 230598, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nrdcprovided by MGI
    Official Full Name
    nardilysin convertaseprovided by MGI
    Primary source
    MGI:MGI:1201386
    See related
    Ensembl:ENSMUSG00000053510 AllianceGenome:MGI:1201386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nrd1; NRD-C; 2600011I06Rik
    Summary
    Predicted to enable peptidase activity. Involved in negative regulation of cold-induced thermogenesis; positive regulation of membrane protein ectodomain proteolysis; and regulation of nervous system development. Located in mitochondrion. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and upper jaw. Orthologous to human NRDC (nardilysin convertase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 91.8), CNS E11.5 (RPKM 25.7) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nrdc in Genome Data Viewer
    Location:
    4 C7; 4 50.77 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108857852..108918974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109000655..109061777)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:108520274-108520575 Neighboring gene thioredoxin domain containing 12 (endoplasmic reticulum) Neighboring gene KTI12 homolog, chromatin associated Neighboring gene RAB3B, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_11058 Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene STARR-seq mESC enhancer starr_11059 Neighboring gene STARR-positive B cell enhancer ABC_E520 Neighboring gene STARR-seq mESC enhancer starr_11060 Neighboring gene microRNA 761 Neighboring gene STARR-seq mESC enhancer starr_11061 Neighboring gene STARR-seq mESC enhancer starr_11062 Neighboring gene oxysterol binding protein-like 9 Neighboring gene predicted gene, 32581 Neighboring gene STARR-positive B cell enhancer mm9_chr4:108777798-108778099 Neighboring gene STARR-positive B cell enhancer ABC_E521 Neighboring gene STARR-positive B cell enhancer ABC_E6198 Neighboring gene STARR-seq mESC enhancer starr_11065 Neighboring gene predicted gene, 52703

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization of nardilysin during mouse oocyte maturation. Ma Z, et al. Arch Biochem Biophys, 2005 Feb 1. PMID 15629122
    2. The use of proteolysis to study the structure of nardilysin. Ma Z, et al. Arch Biochem Biophys, 2002 May 15. PMID 12054470
    3. Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics. Batbaatar MA, et al. Biochem Biophys Res Commun, 2024 Jun 18. PMID 38648679
    4. Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels. Yasuda D, et al. Biol Pharm Bull, 2021. PMID 33642545
    5. [Regulation of protein ectodomain shedding by nardilysin--a critical role of nardilysin in axonal maturation and myelination]. Nishi E. Seikagaku, 2010 Oct. PMID 21077326

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics.
      Title: Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics.
    2. Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
      Title: Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
    3. Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.
      Title: Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.
    4. Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels.
      Title: Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels.
    5. Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor.
      Title: Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor.
    6. integrative studies emphasize the importance of Nrdc for maintaining a proper epigenetic status and cell growth.
      Title: Genome-wide profiling of nardilysin target genes reveals its role in epigenetic regulation and cell cycle progression.
    7. Here, the authors have demonstrated that nardilysin regulates gastric inflammation caused by Helicobacter felis infection or forced expression of prostaglandin. Metaplastic changes following gastric inflammation were suppressed by the deletion of nardilysin. Furthremore, the deletion of nardilysin significantly suppressed N-methyl-N-nitrosourea (MNU)-induced gastric tumorigenesis in the murine stomach.
      Title: Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach.
    8. Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function
      Title: Nardilysin Is Required for Maintaining Pancreatic β-Cell Function.
    9. critical regulator of body temperature homoeostasis
      Title: Critical roles of nardilysin in the maintenance of body temperature homoeostasis.
    10. deletion of nardilysin prevents the development of diet-induced steatohepatitis and liver fibrogenesis
      Title: Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25477

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nardilysin
    Names
    N-arginine dibasic convertase
    NRD convertase
    nardilysin, N-arginine dibasic convertase, NRD convertase 1
    NP_001333483.1
    NP_001334098.1
    NP_666262.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346554.1 → NP_001333483.1  nardilysin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL627406, BE949999
      Consensus CDS
      CCDS89800.1
      UniProtKB/TrEMBL
      A6PWC3, Q8R320
      Related
      ENSMUSP00000099797.3, ENSMUST00000102736.9

    2. NM_001347169.2 → NP_001334098.1  nardilysin isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL627406, BE949999
      Consensus CDS
      CCDS84773.1
      UniProtKB/TrEMBL
      A2A9Q2, Q8R320
      Related
      ENSMUSP00000102255.3, ENSMUST00000106644.9

    3. NM_146150.3 → NP_666262.2  nardilysin isoform 2 precursor

      See identical proteins and their annotated locations for NP_666262.2

      Status: VALIDATED

      Source sequence(s)
      AK031548, BY732391, CF168810
      Consensus CDS
      CCDS18460.1
      UniProtKB/Swiss-Prot
      Q8BHG1
      UniProtKB/TrEMBL
      Q8R320
      Related
      ENSMUSP00000068328.5, ENSMUST00000065977.11
      Conserved Domains (4) summary
      COG1025
      Location:222 → 1100
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:210 → 348
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:373 → 559
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:564 → 845
      Peptidase_M16_M; Middle or third domain of peptidase_M16

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108857852..108918974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHG1.1 GenPept UniProtKB/Swiss-Prot:Q8BHG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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