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    Ppip5k1 diphosphoinositol pentakisphosphate kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311355, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Ppip5k1provided by RGD
    Official Full Name
    diphosphoinositol pentakisphosphate kinase 1provided by RGD
    Primary source
    RGD:1311552
    See related
    EnsemblRapid:ENSRNOG00000014436 AllianceGenome:RGD:1311552
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hisppd2a; RGD1311552
    Summary
    Enables 5-diphosphoinositol pentakisphosphate 1-kinase activity and inositol hexakisphosphate kinase activity. Predicted to be involved in inositol metabolic process and inositol phosphate biosynthetic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Orthologous to human PPIP5K1 (diphosphoinositol pentakisphosphate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 58.1), Kidney (RPKM 51.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppip5k1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128737857..128781408, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108284120..108327683, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113272850..113316324, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 4 Neighboring gene tumor protein p53 binding protein 1 Neighboring gene microtubule-associated protein 1A Neighboring gene creatine kinase, mitochondrial 1 Neighboring gene stereocilin Neighboring gene cation channel, sperm associated 2 Neighboring gene protein disulfide isomerase family A, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. Choi JH, et al. J Biol Chem, 2007 Oct 19. PMID 17702752, Free PMC Article
    2. A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Mulugu S, et al. Science, 2007 Apr 6. PMID 17412958
    3. Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. Fridy PC, et al. J Biol Chem, 2007 Oct 19. PMID 17690096
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5-diphosphoinositol pentakisphosphate 1-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables diphosphoinositol pentakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol hexakisphosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol hexakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol hexakisphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol hexakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
    Names
    PP-IP5 kinase 1
    VIP1 homolog
    histidine acid phosphatase domain containing 2A
    histidine acid phosphatase domain-containing protein 2A
    insP6 and PP-IP5 kinase 1
    NP_001074252.1
    XP_006234900.1
    XP_006234902.1
    XP_008760392.1
    XP_017447227.1
    XP_038960885.1
    XP_038960886.1
    XP_038960892.1
    XP_038960893.1
    XP_038960894.1
    XP_063139788.1
    XP_063139789.1
    XP_063139790.1
    XP_063139791.1
    XP_063139792.1
    XP_063139793.1
    XP_063139794.1
    XP_063139795.1
    XP_063139796.1
    XP_063139797.1
    XP_063139799.1
    XP_063139800.1
    XP_063139801.1
    XP_063139802.1
    XP_063139803.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080783.2 → NP_001074252.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

      See identical proteins and their annotated locations for NP_001074252.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P0C644
      Related
      ENSRNOP00000096590.2, ENSRNOT00000114684.2
      Conserved Domains (2) summary
      pfam00328
      Location:392 → 908
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:57 → 146
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128737857..128781408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234838.5 → XP_006234900.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006234900.1

      UniProtKB/Swiss-Prot
      P0C644
      UniProtKB/TrEMBL
      A0A8I6AQ26
      Related
      ENSRNOP00000095887.1, ENSRNOT00000115690.2
      Conserved Domains (2) summary
      pfam00328
      Location:392 → 908
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:57 → 146
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    2. XM_006234840.5 → XP_006234902.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_006234902.1

      UniProtKB/Swiss-Prot
      P0C644
      UniProtKB/TrEMBL
      A0A8I6AQ26
      Conserved Domains (2) summary
      pfam00328
      Location:392 → 908
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:57 → 146
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    3. XM_039104957.2 → XP_038960885.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      P0C644
      UniProtKB/TrEMBL
      A0A8I6AQ26
      Conserved Domains (2) summary
      pfam00328
      Location:392 → 908
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:57 → 146
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    4. XM_039104958.2 → XP_038960886.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      P0C644
      UniProtKB/TrEMBL
      A0A8I6AQ26
      Conserved Domains (2) summary
      pfam00328
      Location:392 → 908
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:57 → 146
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    5. XM_063283719.1 → XP_063139789.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X3

    6. XM_063283731.1 → XP_063139801.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X14

    7. XM_063283725.1 → XP_063139795.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X9

    8. XM_063283729.1 → XP_063139799.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X12

    9. XM_063283723.1 → XP_063139793.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X7

    10. XM_063283720.1 → XP_063139790.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AVA5

    11. XM_063283722.1 → XP_063139792.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X6

    12. XM_063283718.1 → XP_063139788.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQK2

    13. XM_063283730.1 → XP_063139800.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X13

    14. XM_063283727.1 → XP_063139797.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X11

    15. XM_063283726.1 → XP_063139796.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2K4M9
      Related
      ENSRNOP00000073104.2, ENSRNOT00000091665.3

    16. XM_063283724.1 → XP_063139794.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AB72
      Related
      ENSRNOP00000090965.1, ENSRNOT00000119490.2

    17. XM_063283721.1 → XP_063139791.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X5

      UniProtKB/TrEMBL
      F1LSW6
      Related
      ENSRNOP00000059430.2, ENSRNOT00000065285.4

    18. XM_063283732.1 → XP_063139802.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X16

    19. XM_008762170.2 → XP_008760392.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X15

      UniProtKB/TrEMBL
      A6HPN5
      Conserved Domains (1) summary
      pfam00328
      Location:135 → 651
      His_Phos_2; Histidine phosphatase superfamily (branch 2)

    20. XM_017591738.3 → XP_017447227.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X17

    21. XM_039104964.2 → XP_038960892.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X18

      Conserved Domains (2) summary
      pfam00328
      Location:392 → 908
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:57 → 146
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    22. XM_039104965.2 → XP_038960893.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X19

      Conserved Domains (2) summary
      pfam00328
      Location:392 → 908
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:57 → 146
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    23. XM_039104966.2 → XP_038960894.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X20

      Conserved Domains (2) summary
      pfam00328
      Location:392 → 809
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:57 → 146
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain

    24. XM_063283733.1 → XP_063139803.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X21

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C644.1 GenPept UniProtKB/Swiss-Prot:P0C644

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