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    USP15 ubiquitin specific peptidase 15 [ Gallus gallus (chicken) ]

    Gene ID: 395644, updated on 10-Oct-2024

    Summary

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    Official Symbol
    USP15provided by CGNC
    Official Full Name
    ubiquitin specific peptidase 15provided by CGNC
    Primary source
    CGNC:49421
    See related
    Ensembl:ENSGALG00010011682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    UNP
    Summary
    This gene encodes a protein that is a member of the ubiquitin-specific protease (UBP) family, one of two deubiquitinating enzyme families. Members of the UBP family are characterized by the presence of two conserved motifs, the Cys box and the His box, thought to form part of the active site for these proteases. Deubiquitinating enzymes can cleave either the ubiquitin fusion protein precursors to produce free ubiquitin, or they can cleave ubiquitinated proteins. Proteins are ubiquitinated to target them for degradation, or to target them for a specific cellular location or fate. Two alternative transcripts encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
    Orthologs
    human mouse all
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    Genomic context

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    See USP15 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (33032615..33096457)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (33380232..33444011)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109399 Neighboring gene uncharacterized LOC121109398 Neighboring gene family with sequence similarity 19 member A2, C-C motif chemokine like Neighboring gene uncharacterized LOC121109401 Neighboring gene uncharacterized LOC101750768 Neighboring gene collagen alpha-2(I) chain-like Neighboring gene MON2 homolog, regulator of endosome-to-Golgi trafficking Neighboring gene microRNA let-7i

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases. Baker RT, et al. Genomics, 1999 Aug 1. PMID 10444327
    2. Isolation and characterization of the mouse ubiquitin-specific protease Usp15. Angelats C, et al. Mamm Genome, 2003 Jan. PMID 12532266
    3. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Details changes in nomenclature for human and orthologous USPs
      Title: Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases.
    2. Identification of UNP (AF105715.1) as USP15 and not USP4
      Title: Isolation and characterization of the mouse ubiquitin-specific protease Usp15.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 15
    Names
    ubiquitin specific protease 15
    ubiquitous nuclear protein
    NP_990171.2
    NP_997702.1
    XP_024998506.1
    XP_046761455.1
    XP_046762614.1
    XP_046762615.1
    XP_046762616.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204840.4 → NP_990171.2  ubiquitin carboxyl-terminal hydrolase 15 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAENSK010000012
      UniProtKB/TrEMBL
      A0A1D5P9H5, A0A8V0YAP8
      Related
      ENSGALP00010016054.1, ENSGALT00010027978.1
      Conserved Domains (6) summary
      smart00695
      Location:23 → 121
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:9 → 931
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:783 → 930
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:289 → 473
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:490 → 595
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:135 → 222
      Ubiquitin_3; Ubiquitin-like domain

    2. NM_212537.3 → NP_997702.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      JAENSK010000012
      UniProtKB/TrEMBL
      A0A1D5P1U9, Q9PWC6
      Related
      ENSGALP00010016047.1, ENSGALT00010027968.1
      Conserved Domains (6) summary
      smart00695
      Location:23 → 121
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:9 → 903
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:755 → 902
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:261 → 445
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:462 → 567
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:135 → 222
      Ubiquitin_3; Ubiquitin-like domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      33032615..33096457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025142738.3 → XP_024998506.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YEC8
      Conserved Domains (2) summary
      pfam14836
      Location:14 → 101
      Ubiquitin_3; Ubiquitin-like domain
      cl02553
      Location:161 → 810
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    2. XM_046905499.1 → XP_046761455.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X2

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      33380232..33444011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046906660.1 → XP_046762616.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X3

      Conserved Domains (2) summary
      smart00695
      Location:23 → 121
      DUSP; Domain in ubiquitin-specific proteases
      pfam14836
      Location:135 → 159
      Ubiquitin_3; Ubiquitin-like domain

    2. XM_046906658.1 → XP_046762614.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X1

    3. XM_046906659.1 → XP_046762615.1  ubiquitin carboxyl-terminal hydrolase 15 isoform X2

    RNA

    1. XR_006932638.1 RNA Sequence

    2. XR_006932639.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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