Ube2l6 ubiquitin-conjugating enzyme E2L 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2l6provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2L 6provided by MGI
Primary source: MGI:MGI:1914500
See related: Ensembl:ENSMUSG00000027078 AllianceGenome:MGI:1914500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIG-B; UBCH8; Ubce8; Ubcm8; 2810489I21Rik
Summary: Enables ISG15 transferase activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be active in nucleus. Is expressed in liver. Orthologous to human UBE2L6 (ubiquitin conjugating enzyme E2 L6). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in liver E14 (RPKM 183.6), liver E14.5 (RPKM 167.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 D; 2 49.45 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (84629172..84640347)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (84798828..84810003)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6.
Title: p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6.
Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
Title: Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation.
we have identified a loss-of-function mutation in Ube2l6 that contributes to the chromosome 2 obesity quantitative trait locus.
Title: Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance.
Ubc8 is a major ISG15-conjugating enzyme responsible for protein ISGylation upon interferon stimulation
Title: Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ISG15 transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ISG15 transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ISG15 transferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ISG15-protein conjugation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ISG15-protein conjugation	IDA Inferred from Direct Assay more info	PubMed
involved_in ISG15-protein conjugation	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within modification-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin/ISG15-conjugating enzyme E2 L6

Names: E2 ubiquitin conjugating enzyme; E2 ubiquitin-conjugating enzyme L6; ubiquitin carrier protein L6; ubiquitin-conjugating enzyme 8; ubiquitin-protein ligase L6

NP_064333.2

EC 2.3.2.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019949.2 → NP_064333.2 ubiquitin/ISG15-conjugating enzyme E2 L6

See identical proteins and their annotated locations for NP_064333.2

Status: VALIDATED

Source sequence(s)

AK152113, CJ300190

Consensus CDS

CCDS16194.2

UniProtKB/Swiss-Prot

Q3U8R0, Q922F1, Q9CQN0, Q9QZU9

UniProtKB/TrEMBL

Q4FJY2

Related

ENSMUSP00000099702.3, ENSMUST00000102642.9

Conserved Domains (2) summary

COG5078
Location:1 → 147

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

pfam00179
Location:6 → 144

UQ_con; Ubiquitin-conjugating enzyme