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    Pom121 nuclear pore membrane protein 121 [ Mus musculus (house mouse) ]

    Gene ID: 107939, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pom121provided by MGI
    Official Full Name
    nuclear pore membrane protein 121provided by MGI
    Primary source
    MGI:MGI:2137624
    See related
    Ensembl:ENSMUSG00000053293 AllianceGenome:MGI:2137624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0618; 2610027A18Rik
    Summary
    Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus; nuclear pore organization; and protein import into nucleus. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be part of nuclear pore. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; integumental system; and nervous system. Orthologous to several human genes including POM121 (POM121 transmembrane nucleoporin) and POM121C (POM121 transmembrane nucleoporin C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 46.8), thymus adult (RPKM 22.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pom121 in Genome Data Viewer
    Location:
    5 G2; 5 75.16 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135404994..135433587, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135376140..135404841, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene FK506 binding protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E9263 Neighboring gene tripartite motif-containing 50 Neighboring gene NOL1/NOP2/Sun domain family, member 5 Neighboring gene microRNA 7033 Neighboring gene huntingtin interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10357 Neighboring gene STARR-seq mESC enhancer starr_14578 Neighboring gene STARR-positive B cell enhancer ABC_E434 Neighboring gene predicted gene, 52790 Neighboring gene C-C motif chemokine ligand 26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine. Wang SM, et al. Autophagy, 2023 Jan. PMID 35507432, Free PMC Article
    2. POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation. Ge W, et al. Exp Cell Res, 2019 Apr 15. PMID 30802453
    3. Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans. Olsson M, et al. Exp Cell Res, 2004 Jan 15. PMID 14697343
    4. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264
    5. Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s). Valero MC, et al. Genomics, 2000 Oct 1. PMID 11013070

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.
      Title: Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear pore organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear envelope pore membrane protein POM 121
    Names
    nucleoporin Nup121
    pore membrane protein of 121 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148932.2 → NP_683734.2  nuclear envelope pore membrane protein POM 121

      See identical proteins and their annotated locations for NP_683734.2

      Status: VALIDATED

      Source sequence(s)
      AC024608, BC053101, CF545814, CJ306468, W44309
      Consensus CDS
      CCDS51662.1
      UniProtKB/Swiss-Prot
      Q7TSH5, Q8K3Z9
      UniProtKB/TrEMBL
      Q3U425, Q6A036
      Related
      ENSMUSP00000106801.3, ENSMUST00000111171.6
      Conserved Domains (1) summary
      pfam15229
      Location:292 → 527
      POM121; POM121 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      135404994..135433587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504334.4 → XP_006504397.1  nuclear envelope pore membrane protein POM 121 isoform X1

      UniProtKB/TrEMBL
      Q6A036
      Conserved Domains (3) summary
      PHA03247
      Location:182 → 467
      PHA03247; large tegument protein UL36; Provisional
      PTZ00473
      Location:829 → 930
      PTZ00473; Plasmodium Vir superfamily; Provisional
      pfam15229
      Location:52 → 287
      POM121; POM121 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3Z9.2 GenPept UniProtKB/Swiss-Prot:Q8K3Z9

    Gene LinkOut

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