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    GPR27 G protein-coupled receptor 27 [ Homo sapiens (human) ]

    Gene ID: 2850, updated on 2-Nov-2024

    Summary

    Official Symbol
    GPR27provided by HGNC
    Official Full Name
    G protein-coupled receptor 27provided by HGNC
    Primary source
    HGNC:HGNC:4482
    See related
    Ensembl:ENSG00000170837 MIM:605187; AllianceGenome:HGNC:4482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SREB1
    Summary
    GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.[supplied by OMIM, May 2010]
    Orthologs
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    Genomic context

    See GPR27 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (71753855..71756496)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (71793122..71795766)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (71803006..71805647)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene FOXP1 divergent transcript Neighboring gene uncharacterized LOC105377155 Neighboring gene NANOG hESC enhancer GRCh37_chr3:71694238-71694747 Neighboring gene eukaryotic translation initiation factor 4E family member 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:71752927-71753508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14522 Neighboring gene Sharpr-MPRA regulatory region 3624 Neighboring gene uncharacterized LOC105377156 Neighboring gene prokineticin 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    probable G-protein coupled receptor 27
    Names
    super conserved receptor expressed in brain 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018971.3NP_061844.1  probable G-protein coupled receptor 27

      See identical proteins and their annotated locations for NP_061844.1

      Status: VALIDATED

      Source sequence(s)
      AC096970
      Consensus CDS
      CCDS2915.1
      UniProtKB/Swiss-Prot
      Q9NS67
      UniProtKB/TrEMBL
      F1DAM3
      Related
      ENSP00000303149.2, ENST00000304411.3
      Conserved Domains (1) summary
      cd15216
      Location:19349
      7tmA_SREB1_GPR27; super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      71753855..71756496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      71793122..71795766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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