Stk26 serine/threonine kinase 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stk26provided by MGI
Official Full Name: serine/threonine kinase 26provided by MGI
Primary source: MGI:MGI:1917665
See related: Ensembl:ENSMUSG00000031112 AllianceGenome:MGI:1917665
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mst4; 2610018G03Rik
Summary: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to oxidative stress; microvillus assembly; and protein autophosphorylation. Predicted to be located in several cellular components, including Golgi membrane; Golgi-associated vesicle; and apical plasma membrane. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human STK26 (serine/threonine kinase 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 10.5), thymus adult (RPKM 5.6) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A5; X 27.5 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (49930052..49981980)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (50841174..50893103)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy.
Title: Mst4, a novel cardiac STRIPAK complex-associated kinase, regulates cardiomyocyte growth and survival and is upregulated in human cardiomyopathy.
MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages.
Title: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages.
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.
Title: MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice.
An MST4-pbeta-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.
Title: An MST4-pβ-Catenin(Thr40) Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis.
MST4 modulates the neuro-inflammatory response by regulating IkappaBalpha signaling pathway and affects the early outcome of experimental ischemic stroke in mice.
Title: MST4 modulates the neuro-inflammatory response by regulating IκBα signaling pathway and affects the early outcome of experimental ischemic stroke in mice.
Findings reveal a mechanism by which TRAF6 is regulated and highlight a role for MST4 in limiting inflammatory responses.
Title: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fzd4 (e-PCR), detects polymorphism
- UniSTS:498741

NoName (e-PCR)
- UniSTS:488814

2610018G03Rik (e-PCR), detects polymorphism
- UniSTS:527223

NoName (e-PCR)
- UniSTS:238026

DXMit192 (e-PCR), detects polymorphism
- UniSTS:132084

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in microvillus assembly	IEA Inferred from Electronic Annotation more info
involved_in microvillus assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
part_of FAR/SIN/STRIPAK complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase 26

Names: Mst3 and SOK1-related kinase; STE20-like kinase MST4; mammalian STE20-like protein kinase 4; serine/threonine-protein kinase MST4

NP_001300673.1

EC 2.7.11.1

NP_598490.1

EC 2.7.11.1

XP_017174107.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313744.2 → NP_001300673.1 serine/threonine-protein kinase 26 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL670230, AL671907

UniProtKB/TrEMBL

A2AD84

Conserved Domains (2) summary

cd06640
Location:19 → 295

STKc_MST4; Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4

smart00220
Location:24 → 274

S_TKc; Serine/Threonine protein kinases, catalytic domain
NM_133729.3 → NP_598490.1 serine/threonine-protein kinase 26 isoform 1

See identical proteins and their annotated locations for NP_598490.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL670230, AL671907

Consensus CDS

CCDS40968.1

UniProtKB/Swiss-Prot

Q99JT2

UniProtKB/TrEMBL

A2AD84, A2AD85

Related

ENSMUSP00000033444.5, ENSMUST00000033444.11

Conserved Domains (2) summary

cd06640
Location:19 → 295

STKc_MST4; Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4

smart00220
Location:24 → 274

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

49930052..49981980

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318618.2 → XP_017174107.1 serine/threonine-protein kinase 26 isoform X1

Conserved Domains (1) summary

cl21453
Location:15 → 218

PKc_like; Protein Kinases, catalytic domain