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    Sorcs1 sortilin-related VPS10 domain containing receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 58178, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sorcs1provided by MGI
    Official Full Name
    sortilin-related VPS10 domain containing receptor 1provided by MGI
    Primary source
    MGI:MGI:1929666
    See related
    Ensembl:ENSMUSG00000043531 AllianceGenome:MGI:1929666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sorcs; mSorCS
    Summary
    Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be active in Golgi apparatus and membrane. Is expressed in several structures, including frenulum; genitourinary system; nervous system; sensory organ; and visual system. Orthologous to human SORCS1 (sortilin related VPS10 domain containing receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 3.5), cortex adult (RPKM 3.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sorcs1 in Genome Data Viewer
    Location:
    19 D1; 19 45.05 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (50131733..50668030, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (50143295..50679129, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46394 Neighboring gene siah E3 ubiquitin protein ligase 1, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_46395 Neighboring gene STARR-seq mESC enhancer starr_46396 Neighboring gene ribosomal protein 13A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_46397 Neighboring gene STARR-seq mESC enhancer starr_46398 Neighboring gene STARR-seq mESC enhancer starr_46399 Neighboring gene STARR-seq mESC enhancer starr_46400 Neighboring gene STARR-seq mESC enhancer starr_46401 Neighboring gene STARR-seq mESC enhancer starr_46402 Neighboring gene predicted gene, 26629 Neighboring gene STARR-seq mESC enhancer starr_46403 Neighboring gene STARR-seq mESC enhancer starr_46404 Neighboring gene STARR-seq mESC enhancer starr_46406 Neighboring gene predicted gene, 25644 Neighboring gene STARR-seq mESC enhancer starr_46409 Neighboring gene STARR-seq mESC enhancer starr_46410 Neighboring gene STARR-seq mESC enhancer starr_46411 Neighboring gene ribosomal protein L31, pseudogene 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transient expression of SorCS in developing telencephalic and mesencephalic structures of the mouse. Hermey G, et al. Neuroreport, 2001 Jan 22. PMID 11201086
    2. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Knight EM, et al. Acta Neuropathol Commun, 2016 Feb 25. PMID 26916443, Free PMC Article
    3. Alternative splicing of murine SorCS leads to two forms of the receptor that differ completely in their cytoplasmic tails. Hermey G, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760602
    4. SORCS1 and SORCS3 control energy balance and orexigenic peptide production. Subkhangulova A, et al. EMBO Rep, 2018 Apr. PMID 29440124, Free PMC Article
    5. SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport. Hermey G, et al. J Neurochem, 2015 Oct. PMID 26119586

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SorCS1-mediated sorting in dendritic endosomes controls Nrxn axonal surface polarization required for proper synapse development and function.
      Title: SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.
    2. SorCS1 and SorLA expression were markedly reduced in the frontal cerebral cortex and to a minor extent in the hippocampus, whereas SorCS3 expression was solely reduced in the frontal cerebral cortex
      Title: Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice.
    3. our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production.
      Title: SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
    4. Male mice with either the APP/PSEN1 or Sorcs1 -/- genotype displayed earlier onset and persistent impairment in both glucose homeostasis and in learning behavior.
      Title: Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.
    5. SorCS1 and APP share trafficking pathways and that SorCS1c can retain APP from insertion into anterograde transport vesicles
      Title: SorCS1 variants and amyloid precursor protein (APP) are co-transported in neurons but only SorCS1c modulates anterograde APP transport.
    6. SorCs1 is a global protein trafficking regulator, including AMPA receptors and neurexins.
      Title: The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.
    7. SORCS1 is sufficient to promote secretory granule biogenesis in metabolically stressed beta cells
      Title: SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.
    8. Different motifs regulate trafficking of Sorcs isoforms.
      Title: Different motifs regulate trafficking of SorCS1 isoforms.
    9. SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis
      Title: The three sorCS genes are differentially expressed and regulated by synaptic activity.
    10. identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus
      Title: Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    VPS10 domain-containing receptor SorCS1
    Names
    VPS10 domain receptor protein SORCS 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252501.2 → NP_001239430.1  VPS10 domain-containing receptor SorCS1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
      Source sequence(s)
      AC100726, AC101745, AC131103, AC158463
      Consensus CDS
      CCDS84452.1
      UniProtKB/TrEMBL
      A0A1B0GRC4, Q8BSV0
      Related
      ENSMUSP00000147463.2, ENSMUST00000209413.2
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    2. NM_001290356.2 → NP_001277285.1  VPS10 domain-containing receptor SorCS1 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC100726, AC101745, AC131103, AC158463
      Consensus CDS
      CCDS84451.1
      UniProtKB/TrEMBL
      A0A1B0GT94, Q1HL23
      Related
      ENSMUSP00000148254.2, ENSMUST00000209783.2
      Conserved Domains (2) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain

    3. NM_001360457.2 → NP_001347386.1  VPS10 domain-containing receptor SorCS1 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC100726, AC101745, AC131103, AC158463
      UniProtKB/TrEMBL
      A0A1B0GRB7
      Conserved Domains (2) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain

    4. NM_021377.4 → NP_067352.2  VPS10 domain-containing receptor SorCS1 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC100726, AC101745, AC131103, AC158463
      Consensus CDS
      CCDS84453.1
      UniProtKB/TrEMBL
      A0A1B0GRN1, Q1HL25
      Related
      ENSMUSP00000147591.2, ENSMUST00000211687.2
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      50131733..50668030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251008.2 → XP_030106868.1  VPS10 domain-containing receptor SorCS1 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GRB7
      Conserved Domains (2) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 877
      PKD; PKD domain

    2. XM_017318265.3 → XP_017173754.1  VPS10 domain-containing receptor SorCS1 isoform X3

      Conserved Domains (2) summary
      smart00602
      Location:1 → 316
      VPS10; VPS10 domain
      pfam00801
      Location:330 → 400
      PKD; PKD domain

    3. XM_030251009.2 → XP_030106869.1  VPS10 domain-containing receptor SorCS1 isoform X2

      Conserved Domains (2) summary
      smart00602
      Location:1 → 316
      VPS10; VPS10 domain
      pfam00801
      Location:330 → 400
      PKD; PKD domain

    4. XM_006527243.3 → XP_006527306.1  VPS10 domain-containing receptor SorCS1 isoform X4

      Conserved Domains (2) summary
      smart00602
      Location:1 → 316
      VPS10; VPS10 domain
      pfam00801
      Location:330 → 400
      PKD; PKD domain

    5. XM_006527244.5 → XP_006527307.1  VPS10 domain-containing receptor SorCS1 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GRB7
      Conserved Domains (2) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 877
      PKD; PKD domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLC4.1 GenPept UniProtKB/Swiss-Prot:Q9JLC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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