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    KIF21B kinesin family member 21B [ Homo sapiens (human) ]

    Gene ID: 23046, updated on 3-Nov-2024

    Summary

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    Official Symbol
    KIF21Bprovided by HGNC
    Official Full Name
    kinesin family member 21Bprovided by HGNC
    Primary source
    HGNC:HGNC:29442
    See related
    Ensembl:ENSG00000116852 MIM:608322; AllianceGenome:HGNC:29442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the kinesin superfamily. Kinesins are ATP-dependent microtubule-based motor proteins that are involved in the intracellular transport of membranous organelles. Single nucleotide polymorphisms in this gene are associated with inflammatory bowel disease and multiple sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Biased expression in bone marrow (RPKM 12.6), brain (RPKM 10.5) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF21B in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200969390..201023714, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (200226336..200280656, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200938518..200992842, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200859988-200860816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200863922-200864432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200864433-200864944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200864945-200865455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200866179-200866766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200866767-200867356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1682 Neighboring gene innate immunity activator Neighboring gene RNA, U6 small nuclear 704, pseudogene Neighboring gene maestro heat like repeat family member 3, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2304 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:200945792-200946991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200969230-200969730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200985675-200986222 Neighboring gene Sharpr-MPRA regulatory region 10908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2306 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200991037-200991644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1685 Neighboring gene uncharacterized LOC101929305 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:200993410-200993567 Neighboring gene Sharpr-MPRA regulatory region 14143 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201021057-201021557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201022145-201023102 Neighboring gene calcium voltage-gated channel subunit alpha1 S Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201028065-201028818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:201031613-201032386 Neighboring gene uncharacterized LOC124904481

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Kinesin-4 KIF21B is a potent microtubule pausing factor. van Riel WE, et al. Elife, 2017 Mar 14. PMID 28290984, Free PMC Article
    2. Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A24+ glioma patients. Harada M, et al. Oncol Rep, 2007 Mar. PMID 17273744
    3. Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province. Yang X, et al. Clin Rheumatol, 2015 Oct. PMID 25149646
    4. Replication of KIF21B as a susceptibility locus for multiple sclerosis. Goris A, et al. J Med Genet, 2010 Nov. PMID 20587413
    5. Association of common variants in KIF21B and ankylosing spondylitis in a Chinese Han population: a replication study. Liu Y, et al. Immunogenetics, 2013 Dec. PMID 24065353

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting kinesin family member 21B by miR-132-3p represses cell proliferation, migration and invasion in gastric cancer.
      Title: Targeting kinesin family member 21B by miR-132-3p represses cell proliferation, migration and invasion in gastric cancer.
    2. Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells.
      Title: Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells.
    3. Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity.
      Title: Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity.
    4. Thus, KIF21B combines microtubule-binding and regulatory activities that together constitute an autonomous microtubule pausing factor.
      Title: Kinesin-4 KIF21B is a potent microtubule pausing factor.
    5. KIF21B is associated with ankylosing spondylitis in a Chinese population of Shandong Province
      Title: Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province.
    6. KIF21B may play an important role in the pathogenesis of AS in the Chinese population and might be a new therapeutic target for AS.
      Title: Association of common variants in KIF21B and ankylosing spondylitis in a Chinese Han population: a replication study.
    7. Data show the association of SNPs in KIF21B with multiple sclerosis in a Belgian study population.
      Title: Replication of KIF21B as a susceptibility locus for multiple sclerosis.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Replication of KIF21B as a susceptibility locus for multiple sclerosis.
    9. Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B as susceptibility loci
      Title: Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog
    Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16314

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF21B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047130.1 RefSeqGene

      Range
      4987..59311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001252100.2 → NP_001239029.1  kinesin-like protein KIF21B isoform 1

      See identical proteins and their annotated locations for NP_001239029.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB007918, AL358473, AM177180, BC052964
      Consensus CDS
      CCDS58056.1
      UniProtKB/Swiss-Prot
      B2RP62, B7ZMI0, O75037, Q5T4J3
      UniProtKB/TrEMBL
      Q2UVF0
      Related
      ENSP00000411831.2, ENST00000422435.2
      Conserved Domains (8) summary
      smart00129
      Location:9 → 377
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1306 → 1614
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1305 → 1613
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:7 → 371
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam12474
      Location:660 → 794
      PKK; Polo kinase kinase
      pfam16034
      Location:678 → 806
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:1312 → 1346
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:954 → 1102
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    2. NM_001252102.2 → NP_001239031.1  kinesin-like protein KIF21B isoform 3

      See identical proteins and their annotated locations for NP_001239031.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB007918, AL358473, BC052964, BC137281, DR002414
      Consensus CDS
      CCDS58055.1
      UniProtKB/TrEMBL
      Q2UVF0
      Related
      ENSP00000433808.1, ENST00000461742.7
      Conserved Domains (4) summary
      cd00200
      Location:1305 → 1613
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:7 → 371
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1312 → 1346
      7WD40; WD40 repeat [structural motif]
      cl25732
      Location:366 → 1094
      SMC_N; RecF/RecN/SMC N terminal domain

    3. NM_001252103.2 → NP_001239032.1  kinesin-like protein KIF21B isoform 4

      See identical proteins and their annotated locations for NP_001239032.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR, lacks an in-frame exon in the coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB007918, AL358473, BC052964, BC137281, BC144557, DR002414
      Consensus CDS
      CCDS58054.1
      UniProtKB/TrEMBL
      Q2UVF0
      Related
      ENSP00000353724.5, ENST00000360529.9
      Conserved Domains (8) summary
      smart00129
      Location:9 → 377
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1293 → 1602
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1292 → 1600
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:7 → 371
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam12474
      Location:660 → 794
      PKK; Polo kinase kinase
      pfam16034
      Location:678 → 806
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:1299 → 1333
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:954 → 1102
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    4. NM_017596.4 → NP_060066.2  kinesin-like protein KIF21B isoform 2

      See identical proteins and their annotated locations for NP_060066.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB007918, AL358473, BC052964
      Consensus CDS
      CCDS30965.1
      UniProtKB/TrEMBL
      Q2UVF0
      Related
      ENSP00000328494.2, ENST00000332129.6
      Conserved Domains (8) summary
      smart00129
      Location:9 → 377
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1293 → 1601
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1292 → 1600
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:7 → 371
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam12474
      Location:660 → 794
      PKK; Polo kinase kinase
      pfam16034
      Location:678 → 806
      JAKMIP_CC3; JAKMIP CC3 domain
      sd00039
      Location:1299 → 1333
      7WD40; WD40 repeat [structural motif]
      cl09111
      Location:954 → 1102
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      200969390..201023714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000731.2 → XP_016856220.1  kinesin-like protein KIF21B isoform X1

      UniProtKB/TrEMBL
      Q2UVF0

    2. XM_017000732.2 → XP_016856221.1  kinesin-like protein KIF21B isoform X2

    3. XM_047449818.1 → XP_047305774.1  kinesin-like protein KIF21B isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      200226336..200280656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335269.1 → XP_054191244.1  kinesin-like protein KIF21B isoform X1

    2. XM_054335270.1 → XP_054191245.1  kinesin-like protein KIF21B isoform X2

    3. XM_054335271.1 → XP_054191246.1  kinesin-like protein KIF21B isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75037.2 GenPept UniProtKB/Swiss-Prot:O75037

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