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    ZDHHC24 zinc finger DHHC-type containing 24 [ Homo sapiens (human) ]

    Gene ID: 254359, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZDHHC24provided by HGNC
    Official Full Name
    zinc finger DHHC-type containing 24provided by HGNC
    Primary source
    HGNC:HGNC:27387
    See related
    Ensembl:ENSG00000174165 AllianceGenome:HGNC:27387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen (RPKM 1.8), kidney (RPKM 1.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11q13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66520625..66546048, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66516865..66542290, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66288096..66313519, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66243741-66244561 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66245199-66245792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66246731-66247298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5045 Neighboring gene DPP3 divergent transcript Neighboring gene skeletal muscle cis-regulatory module in DPP3 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66258390-66259340 Neighboring gene dipeptidyl peptidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5046 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298267-66298846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298847-66299424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66307071-66307841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5049 Neighboring gene Sharpr-MPRA regulatory region 1034 Neighboring gene actinin alpha 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66332233-66332732 Neighboring gene cathepsin F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Nat Genet, 2011 Sep 18. PMID 21926972, Free PMC Article
    2. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article
    4. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable palmitoyltransferase ZDHHC24
    Names
    DHHC-24
    zinc finger DHHC domain-containing protein 24
    zinc finger, DHHC domain containing 24
    NP_001335500.1
    NP_997223.1
    XP_005273931.1
    XP_011543195.1
    XP_011543196.1
    XP_047282665.1
    XP_047282666.1
    XP_054224277.1
    XP_054224278.1
    XP_054224279.1
    XP_054224280.1
    XP_054224281.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348571.2 → NP_001335500.1  probable palmitoyltransferase ZDHHC24 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK310561, AP002748
      Consensus CDS
      CCDS86218.1
      UniProtKB/TrEMBL
      E9PLR9
      Related
      ENSP00000431321.1, ENST00000526986.5
      Conserved Domains (1) summary
      cl19890
      Location:95 → 169
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_207340.3 → NP_997223.1  probable palmitoyltransferase ZDHHC24 isoform 1

      See identical proteins and their annotated locations for NP_997223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AP002748, AY358448
      Consensus CDS
      CCDS8143.1
      UniProtKB/Swiss-Prot
      Q6PEW7, Q6UX98, Q9BSJ0
      UniProtKB/TrEMBL
      B4DX31
      Related
      ENSP00000309429.3, ENST00000310442.5
      Conserved Domains (1) summary
      pfam01529
      Location:95 → 234
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      66520625..66546048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273874.5 → XP_005273931.1  probable palmitoyltransferase ZDHHC24 isoform X3

      See identical proteins and their annotated locations for XP_005273931.1

      UniProtKB/TrEMBL
      E9PI61
      Related
      ENSP00000436503.1, ENST00000534073.5
      Conserved Domains (1) summary
      cl19890
      Location:95 → 169
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_047426710.1 → XP_047282666.1  probable palmitoyltransferase ZDHHC24 isoform X4

    3. XM_011544894.3 → XP_011543196.1  probable palmitoyltransferase ZDHHC24 isoform X3

      See identical proteins and their annotated locations for XP_011543196.1

      UniProtKB/TrEMBL
      E9PI61
      Conserved Domains (1) summary
      cl19890
      Location:95 → 169
      zf-DHHC; DHHC palmitoyltransferase

    4. XM_047426709.1 → XP_047282665.1  probable palmitoyltransferase ZDHHC24 isoform X1

    5. XM_011544893.4 → XP_011543195.1  probable palmitoyltransferase ZDHHC24 isoform X2

      Conserved Domains (1) summary
      cl19890
      Location:95 → 169
      zf-DHHC; DHHC palmitoyltransferase

    RNA

    1. XR_007062470.1 RNA Sequence

    2. XR_949860.4 RNA Sequence

    3. XR_007062471.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      66516865..66542290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368304.1 → XP_054224279.1  probable palmitoyltransferase ZDHHC24 isoform X3

      UniProtKB/TrEMBL
      E9PI61

    2. XM_054368306.1 → XP_054224281.1  probable palmitoyltransferase ZDHHC24 isoform X4

    3. XM_054368305.1 → XP_054224280.1  probable palmitoyltransferase ZDHHC24 isoform X3

      UniProtKB/TrEMBL
      E9PI61

    4. XM_054368302.1 → XP_054224277.1  probable palmitoyltransferase ZDHHC24 isoform X1

    5. XM_054368303.1 → XP_054224278.1  probable palmitoyltransferase ZDHHC24 isoform X2

    RNA

    1. XR_008488376.1 RNA Sequence

    2. XR_008488378.1 RNA Sequence

    3. XR_008488377.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UX98.1 GenPept UniProtKB/Swiss-Prot:Q6UX98

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