KIF21A kinesin family member 21A [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF21Aprovided by HGNC
Official Full Name: kinesin family member 21Aprovided by HGNC
Primary source: HGNC:HGNC:19349
See related: Ensembl:ENSG00000139116 MIM:608283; AllianceGenome:HGNC:19349
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FEOM1; CFEOM1; FEOM3A
Summary: This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Expression: Broad expression in brain (RPKM 25.3), kidney (RPKM 9.6) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q12

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (39293228..39443120, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (39243102..39393006, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (39687030..39836922, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
Title: Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
Phenotypic heterogeneity associated with KIF21A: Two new cases and review of the literature.
Title: Phenotypic heterogeneity associated with KIF21A: Two new cases and review of the literature.
Bi-allelic loss-of-function variants in KIF21A cause severe fetal akinesia with arthrogryposis multiplex.
Title: Bi-allelic loss-of-function variants in KIF21A cause severe fetal akinesia with arthrogryposis multiplex.
[Identification of a novel KIF21A gene mutation in a Chinese family with congenital fibrosis of the extraocular muscles].
Title: [Identification of a novel KIF21A gene mutation in a Chinese family with congenital fibrosis of the extraocular muscles].
KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence.
Title: KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence.
KIF21A pathogenic variants cause congenital fibrosis of extraocular muscles type 3.
Title: KIF21A pathogenic variants cause congenital fibrosis of extraocular muscles type 3.
Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles.
Title: Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles.
Prognostic value of Kinesin-4 family genes mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy.
Title: Prognostic value of Kinesin-4 family genes mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy.
Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1.
Title: Structural analyses of key features in the KANK1·KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex.
We describe a recurrent (c.2860C>T) missense KIF21A mutation identified in a Chinese family with CFEOM1 (congenital fibrosis of the extraocular muscles type 1) phenotypes.
Title: Clinical characteristics of a KIF21A mutation in a Chinese family with congenital fibrosis of the extraocular muscles type 1.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital fibrosis of extraocular muscles type 1 MedGen: C1851102 OMIM: 135700 GeneReviews: Congenital Fibrosis of the Extraocular Muscles Overview	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-112391 (e-PCR)
- UniSTS:182533

D12S874 (e-PCR)
- UniSTS:41046

STS-N39407 (e-PCR)
- UniSTS:28529

L17958 (e-PCR)
- UniSTS:46728

G64663 (e-PCR)
- UniSTS:164015

SHGC-106147 (e-PCR)
- UniSTS:169681

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ankyrin repeat binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde axonal transport	IEA Inferred from Electronic Annotation more info
involved_in cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF21A

Names: kinesin-like protein KIF2; renal carcinoma antigen NY-REN-62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_017067.1 RefSeqGene

Range

5271..155163

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001173463.2 → NP_001166934.1 kinesin-like protein KIF21A isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks four in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AB051495, AB290166, AC084373, AW131223, BC136414

Consensus CDS

CCDS53775.1

UniProtKB/TrEMBL

A0A1B0GV47

Related

ENSP00000445606.2, ENST00000544797.6

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1308 → 1618

WD40; WD40 repeat [General function prediction only]

COG2882
Location:655 → 791

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1302 → 1615

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:649 → 786

FliJ; Flagellar FliJ protein

sd00039
Location:1353 → 1412

7WD40; WD40 repeat [structural motif]
NM_001173464.2 → NP_001166935.1 kinesin-like protein KIF21A isoform 1

See identical proteins and their annotated locations for NP_001166935.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB051495, AB290166, AW131223, AY368076

Consensus CDS

CCDS53776.1

UniProtKB/Swiss-Prot

A8MX28, B0I1R9, B9EGE4, F5H0C3, F5H219, Q2UVF1, Q6UKL9, Q7Z4S6, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590

UniProtKB/TrEMBL

A0A1B0GV47

Related

ENSP00000354878.5, ENST00000361418.10

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1345 → 1655

WD40; WD40 repeat [General function prediction only]

COG2882
Location:668 → 804

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1339 → 1652

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:662 → 799

FliJ; Flagellar FliJ protein

sd00039
Location:1390 → 1449

7WD40; WD40 repeat [structural motif]
NM_001173465.2 → NP_001166936.1 kinesin-like protein KIF21A isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks four in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AB051495, AB290166, AC084373, AC090668, AM177179, AW131223, BC041430, DA293947

Consensus CDS

CCDS53774.1

UniProtKB/TrEMBL

A0A1B0GV47

Related

ENSP00000438075.2, ENST00000541463.6

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1292 → 1602

WD40; WD40 repeat [General function prediction only]

COG2882
Location:655 → 791

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1286 → 1599

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:649 → 786

FliJ; Flagellar FliJ protein

sd00039
Location:1337 → 1396

7WD40; WD40 repeat [structural motif]
NM_001378439.1 → NP_001365368.1 kinesin-like protein KIF21A isoform 5

Status: REVIEWED

Source sequence(s)

AC084373, AC090668, AC121334

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (6) summary

COG1196
Location:644 → 1004

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00200
Location:1340 → 1653

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1391 → 1450

7WD40; WD40 repeat [structural motif]

pfam10174
Location:364 → 836

Cast; RIM-binding protein of the cytomatrix active zone

cd22263
Location:936 → 1017

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
NM_001378440.1 → NP_001365369.1 kinesin-like protein KIF21A isoform 6

Status: REVIEWED

Source sequence(s)

AC084373, AC090668, AC121334

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (6) summary

COG1196
Location:644 → 1004

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00200
Location:1335 → 1648

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1386 → 1445

7WD40; WD40 repeat [structural motif]

pfam10174
Location:364 → 836

Cast; RIM-binding protein of the cytomatrix active zone

cd22263
Location:936 → 1017

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
NM_001378441.1 → NP_001365370.1 kinesin-like protein KIF21A isoform 7

Status: REVIEWED

Source sequence(s)

AC084373, AC090668, AC121334

UniProtKB/TrEMBL

A0A1B0GV47

Related

ENSP00000490369.1, ENST00000636569.1

Conserved Domains (6) summary

COG1196
Location:631 → 991

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00200
Location:1327 → 1640

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

sd00039
Location:1378 → 1437

7WD40; WD40 repeat [structural motif]

pfam10174
Location:364 → 823

Cast; RIM-binding protein of the cytomatrix active zone

cd22263
Location:923 → 1004

Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A
NM_017641.4 → NP_060111.2 kinesin-like protein KIF21A isoform 2

See identical proteins and their annotated locations for NP_060111.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AB290166, AC084373, AW131223

Consensus CDS

CCDS31773.1

UniProtKB/TrEMBL

A0A1B0GV47

Related

ENSP00000354851.3, ENST00000361961.7

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1332 → 1642

WD40; WD40 repeat [General function prediction only]

COG2882
Location:655 → 791

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1326 → 1639

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:649 → 786

FliJ; Flagellar FliJ protein

sd00039
Location:1377 → 1436

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

39293228..39443120 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047429133.1 → XP_047285089.1 kinesin-like protein KIF21A isoform X26
XM_047429128.1 → XP_047285084.1 kinesin-like protein KIF21A isoform X18
XM_047429123.1 → XP_047285079.1 kinesin-like protein KIF21A isoform X11
XM_047429129.1 → XP_047285085.1 kinesin-like protein KIF21A isoform X23
XM_017019609.3 → XP_016875098.1 kinesin-like protein KIF21A isoform X20

UniProtKB/TrEMBL

A0A1B0GV47
XM_047429120.1 → XP_047285076.1 kinesin-like protein KIF21A isoform X7
XM_006719493.4 → XP_006719556.1 kinesin-like protein KIF21A isoform X5

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1326 → 1636

WD40; WD40 repeat [General function prediction only]

COG2882
Location:655 → 791

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1320 → 1633

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:649 → 786

FliJ; Flagellar FliJ protein

sd00039
Location:1371 → 1430

7WD40; WD40 repeat [structural motif]
XM_017019611.3 → XP_016875100.1 kinesin-like protein KIF21A isoform X22

UniProtKB/TrEMBL

A0A1B0GV47
XM_047429127.1 → XP_047285083.1 kinesin-like protein KIF21A isoform X17
XM_017019608.3 → XP_016875097.1 kinesin-like protein KIF21A isoform X9

UniProtKB/TrEMBL

A0A1B0GV47
XM_017019607.3 → XP_016875096.1 kinesin-like protein KIF21A isoform X3

UniProtKB/TrEMBL

A0A1B0GV47
XM_047429132.1 → XP_047285088.1 kinesin-like protein KIF21A isoform X25
XM_047429125.1 → XP_047285081.1 kinesin-like protein KIF21A isoform X15
XM_047429130.1 → XP_047285086.1 kinesin-like protein KIF21A isoform X24
XM_047429122.1 → XP_047285078.1 kinesin-like protein KIF21A isoform X10
XM_011538556.4 → XP_011536858.1 kinesin-like protein KIF21A isoform X6

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1323 → 1633

WD40; WD40 repeat [General function prediction only]

COG2882
Location:668 → 804

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1317 → 1630

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:662 → 799

FliJ; Flagellar FliJ protein

sd00039
Location:1368 → 1427

7WD40; WD40 repeat [structural motif]
XM_017019610.3 → XP_016875099.1 kinesin-like protein KIF21A isoform X21

UniProtKB/TrEMBL

A0A1B0GV47
XM_047429126.1 → XP_047285082.1 kinesin-like protein KIF21A isoform X16
XM_047429121.1 → XP_047285077.1 kinesin-like protein KIF21A isoform X8
XM_047429119.1 → XP_047285075.1 kinesin-like protein KIF21A isoform X2
XM_005269009.4 → XP_005269066.1 kinesin-like protein KIF21A isoform X1

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1339 → 1649

WD40; WD40 repeat [General function prediction only]

COG2882
Location:668 → 804

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1333 → 1646

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:662 → 799

FliJ; Flagellar FliJ protein

sd00039
Location:1384 → 1443

7WD40; WD40 repeat [structural motif]
XM_005269014.4 → XP_005269071.1 kinesin-like protein KIF21A isoform X19

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1285 → 1595

WD40; WD40 repeat [General function prediction only]

COG2882
Location:668 → 804

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1279 → 1592

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:662 → 799

FliJ; Flagellar FliJ protein

sd00039
Location:1330 → 1389

7WD40; WD40 repeat [structural motif]
XM_005269013.4 → XP_005269070.1 kinesin-like protein KIF21A isoform X14

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1298 → 1608

WD40; WD40 repeat [General function prediction only]

COG2882
Location:668 → 804

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1292 → 1605

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:662 → 799

FliJ; Flagellar FliJ protein

sd00039
Location:1343 → 1402

7WD40; WD40 repeat [structural motif]
XM_006719494.4 → XP_006719557.1 kinesin-like protein KIF21A isoform X13

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1302 → 1612

WD40; WD40 repeat [General function prediction only]

COG2882
Location:668 → 804

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1296 → 1609

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:662 → 799

FliJ; Flagellar FliJ protein

sd00039
Location:1347 → 1406

7WD40; WD40 repeat [structural motif]
XM_005269012.4 → XP_005269069.1 kinesin-like protein KIF21A isoform X12

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1303 → 1613

WD40; WD40 repeat [General function prediction only]

COG2882
Location:668 → 804

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1297 → 1610

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:662 → 799

FliJ; Flagellar FliJ protein

sd00039
Location:1348 → 1407

7WD40; WD40 repeat [structural motif]
XM_005269011.4 → XP_005269068.1 kinesin-like protein KIF21A isoform X4

UniProtKB/TrEMBL

A0A1B0GV47

Conserved Domains (7) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1328 → 1638

WD40; WD40 repeat [General function prediction only]

COG2882
Location:668 → 804

FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]

cd00200
Location:1322 → 1635

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:8 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam02050
Location:662 → 799

FliJ; Flagellar FliJ protein

sd00039
Location:1373 → 1432

7WD40; WD40 repeat [structural motif]