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    TJAP1 tight junction associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 93643, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TJAP1provided by HGNC
    Official Full Name
    tight junction associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17949
    See related
    Ensembl:ENSG00000137221 MIM:612658; AllianceGenome:HGNC:17949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PILT; TJP4
    Summary
    This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]
    Expression
    Ubiquitous expression in ovary (RPKM 10.1), endometrium (RPKM 8.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    6p21.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43477570..43506554)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43306318..43335293)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43445308..43474292)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily C member 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43423943-43424784 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene MPRA-validated peak5814 silencer Neighboring gene RNA, U6 small nuclear 1113, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43445658-43446451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43457381-43457974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43457975-43458569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17234 Neighboring gene leucine rich repeat containing 73 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24602 Neighboring gene Yip1 domain family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells. Kawabe H, et al. J Biol Chem, 2001 Dec 21. PMID 11602598
    2. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. Deng X, et al. PLoS One, 2013. PMID 24324551, Free PMC Article
    3. BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters. Kannangara AR, et al. EMBO Rep, 2021 Oct 5. PMID 34369648, Free PMC Article
    4. LINKIN, a new transmembrane protein necessary for cell adhesion. Kato M, et al. Elife, 2014 Dec 1. PMID 25437307, Free PMC Article
    5. Protein interactome reveals converging molecular pathways among autism disorders. Sakai Y, et al. Sci Transl Med, 2011 Jun 8. PMID 21653829, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686F06131

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tight junction-associated protein 1
    Names
    protein incorporated later into tight junctions
    tight junction associated protein 1 (peripheral)
    tight junction protein 4 (peripheral)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146016.2 → NP_001139488.1  tight junction-associated protein 1 isoform a

      See identical proteins and their annotated locations for NP_001139488.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 8-15 all encode the same isoform (a).
      Source sequence(s)
      AK074241, BC046239, DA018836
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Related
      ENSP00000361522.5, ENST00000372445.9
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    2. NM_001146017.2 → NP_001139489.1  tight junction-associated protein 1 isoform a

      See identical proteins and their annotated locations for NP_001139489.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 8-15 all encode the same isoform (a).
      Source sequence(s)
      AK074241, DA297698, DA415818
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Related
      ENSP00000408769.2, ENST00000438588.6
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    3. NM_001146018.2 → NP_001139490.1  tight junction-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_001139490.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 3-6, 16, and 17 all encode the same isoform (b).
      Source sequence(s)
      BC064401, DA098538
      Consensus CDS
      CCDS4898.1
      Related
      ENSP00000361521.2, ENST00000372444.6
      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    4. NM_001146019.2 → NP_001139491.1  tight junction-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_001139491.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 3-6, 16 and 17 all encode the same isoform (b).
      Source sequence(s)
      AK074241, AK225787
      Consensus CDS
      CCDS4898.1
      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    5. NM_001146020.2 → NP_001139492.1  tight junction-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_001139492.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 3-6, 16, and 17 all encode the same isoform (b).
      Source sequence(s)
      AK074241, DA051961
      Consensus CDS
      CCDS4898.1
      Related
      ENSP00000407080.2, ENST00000436109.6
      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    6. NM_001350561.2 → NP_001337490.1  tight junction-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 2, and 9-15, encodes isoform a.
      Source sequence(s)
      AL355802, AL359813
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    7. NM_001350562.2 → NP_001337491.1  tight junction-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 2, 8, and 10-15, encodes isoform a.
      Source sequence(s)
      AL355802, AL359813
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Related
      ENSP00000361527.1, ENST00000372449.6
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    8. NM_001350563.2 → NP_001337492.1  tight junction-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 2, 8, 9, and 11-15, encodes isoform a.
      Source sequence(s)
      AL355802, AL359813
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    9. NM_001350564.2 → NP_001337493.1  tight junction-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 2, 8-10, and 12-15, encodes isoform a.
      Source sequence(s)
      AL355802, AL359813
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    10. NM_001350565.2 → NP_001337494.1  tight junction-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 2, 8-11, and 13-15, encodes isoform a.
      Source sequence(s)
      AL355802
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    11. NM_001350566.2 → NP_001337495.1  tight junction-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1, 2, 8-12, 14, and 15, encodes isoform a.
      Source sequence(s)
      AL355802
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    12. NM_001350567.2 → NP_001337496.1  tight junction-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 1, 2, 8-13, and 15, encodes isoform a.
      Source sequence(s)
      AL355802
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    13. NM_001350568.2 → NP_001337497.1  tight junction-associated protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 1, 2, and 8-14, encodes isoform a.
      Source sequence(s)
      AL355802
      Consensus CDS
      CCDS55004.1
      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    14. NM_001350569.2 → NP_001337498.1  tight junction-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 3-6 and 17, encodes isoform b.
      Source sequence(s)
      AL355802, AL359813
      Consensus CDS
      CCDS4898.1
      Related
      ENSP00000361530.1, ENST00000372452.5
      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    15. NM_001350570.2 → NP_001337499.1  tight junction-associated protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 3-6 and 16, encodes isoform b.
      Source sequence(s)
      AL355802, AL359813
      Consensus CDS
      CCDS4898.1
      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    16. NM_001394538.1 → NP_001381467.1  tight junction-associated protein 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813
      UniProtKB/TrEMBL
      B3KT40
      Conserved Domains (2) summary
      TIGR02168
      Location:4 → 137
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15453
      Location:243 → 515
      Pilt; Protein incorporated later into Tight Junctions

    17. NM_001394539.1 → NP_001381468.1  tight junction-associated protein 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813
      UniProtKB/TrEMBL
      B3KT40
      Conserved Domains (2) summary
      TIGR02168
      Location:4 → 137
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15453
      Location:243 → 515
      Pilt; Protein incorporated later into Tight Junctions

    18. NM_001394540.1 → NP_001381469.1  tight junction-associated protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813
      UniProtKB/TrEMBL
      B3KT40
      Conserved Domains (2) summary
      COG1196
      Location:4 → 112
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:233 → 505
      Pilt; Protein incorporated later into Tight Junctions

    19. NM_001394541.1 → NP_001381470.1  tight junction-associated protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813
      UniProtKB/TrEMBL
      B3KT40
      Conserved Domains (2) summary
      COG1196
      Location:4 → 112
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:233 → 505
      Pilt; Protein incorporated later into Tight Junctions

    20. NM_001394542.1 → NP_001381471.1  tight junction-associated protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813
      UniProtKB/TrEMBL
      B3KT40
      Conserved Domains (2) summary
      COG1196
      Location:4 → 112
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:233 → 505
      Pilt; Protein incorporated later into Tight Junctions

    21. NM_001394543.1 → NP_001381472.1  tight junction-associated protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813
      UniProtKB/TrEMBL
      B3KT40
      Conserved Domains (2) summary
      COG1196
      Location:4 → 112
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:233 → 505
      Pilt; Protein incorporated later into Tight Junctions

    22. NM_001394544.1 → NP_001381473.1  tight junction-associated protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813
      UniProtKB/TrEMBL
      B3KT40
      Conserved Domains (2) summary
      COG1196
      Location:4 → 112
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:233 → 505
      Pilt; Protein incorporated later into Tight Junctions

    23. NM_001394545.1 → NP_001381474.1  tight junction-associated protein 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813
      UniProtKB/TrEMBL
      B3KT40
      Conserved Domains (2) summary
      COG1196
      Location:4 → 112
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:233 → 505
      Pilt; Protein incorporated later into Tight Junctions

    24. NM_080604.3 → NP_542171.2  tight junction-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_542171.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a. Variants 3-6, 16, and 17 all encode the same isoform (b).
      Source sequence(s)
      AK024269, AK074241, DA018836
      Consensus CDS
      CCDS4898.1
      Related
      ENSP00000259751.1, ENST00000259751.5
      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. NR_146793.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL355802, AL359813

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43477570..43506554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011489.2 → XP_016866978.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    2. XM_047419532.1 → XP_047275488.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    3. XM_047419534.1 → XP_047275490.1  tight junction-associated protein 1 isoform X2

    4. XM_047419536.1 → XP_047275492.1  tight junction-associated protein 1 isoform X2

    5. XM_047419531.1 → XP_047275487.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    6. XM_047419538.1 → XP_047275494.1  tight junction-associated protein 1 isoform X2

    7. XM_047419529.1 → XP_047275485.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    8. XM_047419530.1 → XP_047275486.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    9. XM_024446586.2 → XP_024302354.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    10. XM_047419542.1 → XP_047275498.1  tight junction-associated protein 1 isoform X2

    11. XM_024446584.2 → XP_024302352.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    12. XM_017011492.2 → XP_016866981.1  tight junction-associated protein 1 isoform X2

      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    13. XM_024446585.2 → XP_024302353.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    14. XM_017011493.2 → XP_016866982.1  tight junction-associated protein 1 isoform X2

      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    15. XM_047419540.1 → XP_047275496.1  tight junction-associated protein 1 isoform X2

    16. XM_006715250.5 → XP_006715313.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715313.1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    17. XM_011514995.2 → XP_011513297.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011513297.1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    18. XM_047419533.1 → XP_047275489.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    19. XM_024446587.2 → XP_024302355.1  tight junction-associated protein 1 isoform X2

      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    20. XM_047419537.1 → XP_047275493.1  tight junction-associated protein 1 isoform X2

    21. XM_006715251.4 → XP_006715314.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715314.1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    22. XM_047419541.1 → XP_047275497.1  tight junction-associated protein 1 isoform X2

    23. XM_047419544.1 → XP_047275500.1  tight junction-associated protein 1 isoform X2

    24. XM_006715257.3 → XP_006715320.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715320.1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    25. XM_047419543.1 → XP_047275499.1  tight junction-associated protein 1 isoform X2

    26. XM_006715254.5 → XP_006715317.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715317.1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    27. XM_047419535.1 → XP_047275491.1  tight junction-associated protein 1 isoform X2

    28. XM_006715265.2 → XP_006715328.1  tight junction-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006715328.1

      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    29. XM_006715263.3 → XP_006715326.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715326.1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    30. XM_047419545.1 → XP_047275501.1  tight junction-associated protein 1 isoform X2

    31. XM_006715266.2 → XP_006715329.1  tight junction-associated protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006715329.1

      Conserved Domains (2) summary
      pfam15453
      Location:274 → 546
      Pilt; Protein incorporated later into Tight Junctions
      cl25732
      Location:17 → 161
      SMC_N; RecF/RecN/SMC N terminal domain

    32. XM_006715261.2 → XP_006715324.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715324.1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    33. XM_047419547.1 → XP_047275503.1  tight junction-associated protein 1 isoform X4

    34. XM_047419548.1 → XP_047275504.1  tight junction-associated protein 1 isoform X4

    35. XM_047419546.1 → XP_047275502.1  tight junction-associated protein 1 isoform X3

      Related
      ENSP00000390981.2, ENST00000442878.6

    36. XM_006715262.3 → XP_006715325.1  tight junction-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006715325.1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
      Conserved Domains (2) summary
      COG1196
      Location:17 → 163
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15453
      Location:284 → 556
      Pilt; Protein incorporated later into Tight Junctions

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      43306318..43335293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356772.1 → XP_054212747.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    2. XM_054356768.1 → XP_054212743.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    3. XM_054356774.1 → XP_054212749.1  tight junction-associated protein 1 isoform X2

    4. XM_054356779.1 → XP_054212754.1  tight junction-associated protein 1 isoform X2

    5. XM_054356767.1 → XP_054212742.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    6. XM_054356781.1 → XP_054212756.1  tight junction-associated protein 1 isoform X2

    7. XM_054356763.1 → XP_054212738.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    8. XM_054356765.1 → XP_054212740.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    9. XM_054356762.1 → XP_054212737.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    10. XM_054356786.1 → XP_054212761.1  tight junction-associated protein 1 isoform X2

    11. XM_054356758.1 → XP_054212733.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    12. XM_054356777.1 → XP_054212752.1  tight junction-associated protein 1 isoform X2

    13. XM_054356769.1 → XP_054212744.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    14. XM_054356778.1 → XP_054212753.1  tight junction-associated protein 1 isoform X2

    15. XM_054356783.1 → XP_054212758.1  tight junction-associated protein 1 isoform X2

    16. XM_054356764.1 → XP_054212739.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    17. XM_054356757.1 → XP_054212732.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    18. XM_054356770.1 → XP_054212745.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    19. XM_054356775.1 → XP_054212750.1  tight junction-associated protein 1 isoform X2

    20. XM_054356780.1 → XP_054212755.1  tight junction-associated protein 1 isoform X2

    21. XM_054356759.1 → XP_054212734.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    22. XM_054356784.1 → XP_054212759.1  tight junction-associated protein 1 isoform X2

    23. XM_054356788.1 → XP_054212763.1  tight junction-associated protein 1 isoform X2

    24. XM_054356766.1 → XP_054212741.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    25. XM_054356787.1 → XP_054212762.1  tight junction-associated protein 1 isoform X2

    26. XM_054356761.1 → XP_054212736.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    27. XM_054356776.1 → XP_054212751.1  tight junction-associated protein 1 isoform X2

    28. XM_054356782.1 → XP_054212757.1  tight junction-associated protein 1 isoform X2

    29. XM_054356771.1 → XP_054212746.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    30. XM_054356789.1 → XP_054212764.1  tight junction-associated protein 1 isoform X2

    31. XM_054356785.1 → XP_054212760.1  tight junction-associated protein 1 isoform X2

    32. XM_054356760.1 → XP_054212735.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7

    33. XM_054356791.1 → XP_054212766.1  tight junction-associated protein 1 isoform X4

    34. XM_054356792.1 → XP_054212767.1  tight junction-associated protein 1 isoform X4

    35. XM_054356790.1 → XP_054212765.1  tight junction-associated protein 1 isoform X3

    36. XM_054356773.1 → XP_054212748.1  tight junction-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q05BH9, Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JTD0.1 GenPept UniProtKB/Swiss-Prot:Q5JTD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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