Smim20 small integral membrane protein 20 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Smim20provided by RGD
Official Full Name: small integral membrane protein 20provided by RGD
Primary source: RGD:1565192
See related: AllianceGenome:RGD:1565192
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PNX; MITRAC7; RGD1565192
Summary: Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in extracellular region; membrane; and mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SMIM20 (small integral membrane protein 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 487.8), Muscle (RPKM 322.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (61924155..61935630, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (57711304..57722681, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (60057493..60069870, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic unpredictable stress (CUS) reduced phoenixin expression, induced abnormal sperm and testis morphology in male rats.
Title: Chronic unpredictable stress (CUS) reduced phoenixin expression, induced abnormal sperm and testis morphology in male rats.
Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem.
Title: Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem.
Restraint stress affects circulating NUCB2/nesfatin-1 and phoenixin levels in male rats.
Title: Restraint stress affects circulating NUCB2/nesfatin-1 and phoenixin levels in male rats.
Phoenixin may represent a new class of hypothalamically-derived pituitary priming factors that sensitize the pituitary to the action of other releasing factors.
Title: A novel reproductive peptide, phoenixin.
phoenixin induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats.
Title: Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones.

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General gene information

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Markers

RH143720 (e-PCR)
- UniSTS:232966

RH131307 (e-PCR)
- UniSTS:214590

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small integral membrane protein 20

Names: mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa; phoenixin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.