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    Rpl35a ribosomal protein L35A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 57809, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rpl35aprovided by RGD
    Official Full Name
    ribosomal protein L35Aprovided by RGD
    Primary source
    RGD:2323795
    See related
    AllianceGenome:RGD:2323795
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rpl35al1
    Summary
    Enables ribonucleoprotein complex binding activity. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 5. Orthologous to human RPL35A (ribosomal protein L35a). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 2780.3), Spleen (RPKM 2675.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpl35a in Genome Data Viewer
    Location:
    11q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81231114..81235094, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67726031..67729953, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (7186459..7186874, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481083 Neighboring gene oxysterol binding protein-like 11 Neighboring gene leishmanolysin like peptidase Neighboring gene IQ motif containing G Neighboring gene leucine rich repeats and calponin homology domain containing 3 Neighboring gene uncharacterized LOC134481085

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification by affinity chromatography of the rat liver ribosomal proteins that bind to Escherichia coli 5 S ribosomal ribonucleic acid. Ulbrich N, et al. J Biol Chem, 1980 Jan 25. PMID 6985899
    2. The identification by affinity chromatography of the rat liver ribosomal proteins that bind to elongator and initiator transfer ribonucleic acids. Ulbrich N, et al. J Biol Chem, 1980 Jul 25. PMID 7391064
    3. Nucleotide sequence of cloned cDNA specific for rat ribosomal protein L35a. Tanaka T, et al. Eur J Biochem, 1986 Feb 3. PMID 3753935
    4. The identification of novel therapeutic targets for the treatment of malignant brain tumors. Kroes RA, et al. Cancer Lett, 2000 Aug 11. PMID 10880769
    5. Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Farrar JE, et al. Blood, 2008 Sep 1. PMID 18535205, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72845

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL33
    Names
    60S ribosomal protein L35a
    ribosomal protein L35a-like
    ribosomal protein L35a-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021264.4 → NP_067087.1  large ribosomal subunit protein eL33

      See identical proteins and their annotated locations for NP_067087.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P04646
      UniProtKB/TrEMBL
      A0A8L2QJQ6, A6IRM5
      Conserved Domains (1) summary
      pfam01247
      Location:5 → 103
      Ribosomal_L35Ae; Ribosomal protein L35Ae

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      81231114..81235094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270728.1 → XP_063126798.1  large ribosomal subunit protein eL33 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKL5

    2. XM_063270732.1 → XP_063126802.1  large ribosomal subunit protein eL33 isoform X3

    3. XM_063270723.1 → XP_063126793.1  large ribosomal subunit protein eL33 isoform X1

    4. XM_002727895.7 → XP_002727941.1  large ribosomal subunit protein eL33 isoform X4

      See identical proteins and their annotated locations for XP_002727941.1

      UniProtKB/Swiss-Prot
      P04646
      UniProtKB/TrEMBL
      A0A8L2QJQ6, A6IRM5
      Conserved Domains (1) summary
      pfam01247
      Location:5 → 103
      Ribosomal_L35Ae; Ribosomal protein L35Ae

    5. XM_063270729.1 → XP_063126799.1  large ribosomal subunit protein eL33 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKL5

    6. XM_063270724.1 → XP_063126794.1  large ribosomal subunit protein eL33 isoform X1

    7. XM_063270735.1 → XP_063126805.1  large ribosomal subunit protein eL33 isoform X4

      UniProtKB/Swiss-Prot
      P04646
      UniProtKB/TrEMBL
      A6IRM5

    8. XM_063270734.1 → XP_063126804.1  large ribosomal subunit protein eL33 isoform X4

      UniProtKB/Swiss-Prot
      P04646
      UniProtKB/TrEMBL
      A6IRM5

    9. XM_063270727.1 → XP_063126797.1  large ribosomal subunit protein eL33 isoform X1

    10. XM_063270730.1 → XP_063126800.1  large ribosomal subunit protein eL33 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKL5

    11. XM_063270726.1 → XP_063126796.1  large ribosomal subunit protein eL33 isoform X1

    12. XM_063270725.1 → XP_063126795.1  large ribosomal subunit protein eL33 isoform X1

    13. XM_063270731.1 → XP_063126801.1  large ribosomal subunit protein eL33 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKL5

    14. XM_063270733.1 → XP_063126803.1  large ribosomal subunit protein eL33 isoform X4

      UniProtKB/Swiss-Prot
      P04646
      UniProtKB/TrEMBL
      A6IRM5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04646.1 GenPept UniProtKB/Swiss-Prot:P04646

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