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    Cttnbp2nl CTTNBP2 N-terminal like [ Mus musculus (house mouse) ]

    Gene ID: 80281, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cttnbp2nlprovided by MGI
    Official Full Name
    CTTNBP2 N-terminal likeprovided by MGI
    Primary source
    MGI:MGI:1933137
    See related
    Ensembl:ENSMUSG00000062127 AllianceGenome:MGI:1933137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1433
    Summary
    Predicted to enable protein phosphatase 2A binding activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in cytoplasm; lamellipodium; and stress fiber. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including alimentary system; axial musculature; orbito-sphenoid; submandibular gland primordium; and urinary system. Orthologous to human CTTNBP2NL (CTTNBP2 N-terminal like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 8.8), CNS E11.5 (RPKM 6.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cttnbp2nl in Genome Data Viewer
    Location:
    3 F2.2; 3 45.88 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104909231..104960462, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105001915..105053146, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene wingless-type MMTV integration site family, member 2B Neighboring gene predicted gene, 46819 Neighboring gene uncharacterized LOC118568635 Neighboring gene predicted gene, 40116 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104855959-104856068 Neighboring gene RIKEN cDNA 4930564D02 gene Neighboring gene STARR-seq mESC enhancer starr_08630 Neighboring gene predicted gene, 40118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:104936010-104936231

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic variants related to gap junctions and hormone secretion influence conception rates in cows. Sugimoto M, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218568, Free PMC Article
    2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    3. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7720

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FAR/SIN/STRIPAK complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CTTNBP2 N-terminal-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163332.2 → NP_001156804.1  CTTNBP2 N-terminal-like protein

      See identical proteins and their annotated locations for NP_001156804.1

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      Consensus CDS
      CCDS17707.1
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0
      Related
      ENSMUSP00000096359.3, ENSMUST00000098763.7
      Conserved Domains (3) summary
      PHA03247
      Location:482 → 638
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:100 → 292
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09727
      Location:5 → 188
      CortBP2; Cortactin-binding protein-2

    2. NM_001163333.2 → NP_001156805.1  CTTNBP2 N-terminal-like protein

      See identical proteins and their annotated locations for NP_001156805.1

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      Consensus CDS
      CCDS17707.1
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0
      Conserved Domains (3) summary
      PHA03247
      Location:482 → 638
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:100 → 292
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09727
      Location:5 → 188
      CortBP2; Cortactin-binding protein-2

    3. NM_001411186.1 → NP_001398115.1  CTTNBP2 N-terminal-like protein

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0

    4. NM_001411188.1 → NP_001398117.1  CTTNBP2 N-terminal-like protein

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0

    5. NM_001411189.1 → NP_001398118.1  CTTNBP2 N-terminal-like protein

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0

    6. NM_001411190.1 → NP_001398119.1  CTTNBP2 N-terminal-like protein

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0

    7. NM_001411191.1 → NP_001398120.1  CTTNBP2 N-terminal-like protein

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0

    8. NM_001411192.1 → NP_001398121.1  CTTNBP2 N-terminal-like protein

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0

    9. NM_001411193.1 → NP_001398122.1  CTTNBP2 N-terminal-like protein

      Status: VALIDATED

      Source sequence(s)
      AC141889, AC166156
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0

    10. NM_030249.4 → NP_084525.1  CTTNBP2 N-terminal-like protein

      See identical proteins and their annotated locations for NP_084525.1

      Status: VALIDATED

      Source sequence(s)
      AC166156, AK029901
      Consensus CDS
      CCDS17707.1
      UniProtKB/Swiss-Prot
      Q6ZPR0, Q8BSV1, Q922L8, Q99LJ0
      Related
      ENSMUSP00000076751.6, ENSMUST00000077548.12
      Conserved Domains (3) summary
      PHA03247
      Location:482 → 638
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:100 → 292
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09727
      Location:5 → 188
      CortBP2; Cortactin-binding protein-2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104909231..104960462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LJ0.1 GenPept UniProtKB/Swiss-Prot:Q99LJ0

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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