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    LANCL3 LanC like family member 3 [ Homo sapiens (human) ]

    Gene ID: 347404, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LANCL3provided by HGNC
    Official Full Name
    LanC like family member 3provided by HGNC
    Primary source
    HGNC:HGNC:24767
    See related
    Ensembl:ENSG00000147036 AllianceGenome:HGNC:24767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in carbohydrate metabolic process and peptide modification. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See LANCL3 in Genome Data Viewer
    Location:
    Xp21.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (37571661..37684463)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (36975217..37088020)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37430914..37543716)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ferritin heavy chain 1 pseudogene 27 Neighboring gene family with sequence similarity 47 member D, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:37544835-37545346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:37545347-37545856 Neighboring gene H2A.L variant histone 1M, pseudogene Neighboring gene X-linked Kx blood group antigen, Kell and VPS13A binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29519 Neighboring gene cytochrome b-245 beta chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Gene expression in proliferating human erythroid cells. Gubin AN, et al. Genomics, 1999 Jul 15. PMID 10409428
    2. Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell. Bartolec TK, et al. Proc Natl Acad Sci U S A, 2023 Apr 25. PMID 37071682, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42925

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lanC-like protein 3
    Names
    LanC lantibiotic synthetase component C-like 3
    LanC like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016368.2 RefSeqGene

      Range
      5002..117804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170331.2 → NP_001163802.1  lanC-like protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001163802.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC233297, AI989993, AK124915, BG944288
      Consensus CDS
      CCDS55398.1
      UniProtKB/Swiss-Prot
      A6NHE3, Q6ZV70
      Related
      ENSP00000367882.4, ENST00000378619.4
      Conserved Domains (1) summary
      cd04794
      Location:65 → 414
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

    2. NM_198511.3 → NP_940913.1  lanC-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_940913.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC233297, AI989993, AK124915, BG944288
      Consensus CDS
      CCDS14240.1
      UniProtKB/Swiss-Prot
      Q6ZV70
      Related
      ENSP00000367885.3, ENST00000378621.7
      Conserved Domains (1) summary
      cd04794
      Location:65 → 367
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      37571661..37684463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543904.3 → XP_011542206.1  lanC-like protein 3 isoform X1

      Conserved Domains (1) summary
      cd04794
      Location:7 → 232
      euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      36975217..37088020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326995.1 → XP_054182970.1  lanC-like protein 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZV70.2 GenPept UniProtKB/Swiss-Prot:Q6ZV70

    Gene LinkOut

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