TJP1 tight junction protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TJP1provided by HGNC
Official Full Name: tight junction protein 1provided by HGNC
Primary source: HGNC:HGNC:11827
See related: Ensembl:ENSG00000104067 MIM:601009; AllianceGenome:HGNC:11827
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZO-1
Summary: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in testis (RPKM 23.9), placenta (RPKM 23.2) and 24 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15q13.1

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (29699367..29969049, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (27490136..27760675, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (29991571..30261252, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-kappaB-RhoA signal pathway.
Title: IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-κB-RhoA signal pathway.
TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.
Title: TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.
circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.
Title: circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.
CLDN6 inhibits colorectal cancer proliferation dependent on restraining p53 ubiquitination via ZO-1/PTEN axis.
Title: CLDN6 inhibits colorectal cancer proliferation dependent on restraining p53 ubiquitination via ZO-1/PTEN axis.
Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.
Title: Rabeprazole destroyed gastric epithelial barrier function through FOXF1/STAT3-mediated ZO-1 expression.
Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.
Title: Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells.
ZO-1 expression in normal human macula densa: Immunohistochemical and immunofluorescence investigations.
Title: ZO-1 expression in normal human macula densa: Immunohistochemical and immunofluorescence investigations.
Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis.
Title: Hypoxic nasopharyngeal carcinoma-derived exosomal miR-455 increases vascular permeability by targeting ZO-1 to promote metastasis.
[Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].
Title: [Porphyromonas gingivalis infection causes umbilical vein endothelial barrier dysfunction in vitro by down-regulating ZO-1, occludin and VE-cadherin expression].
Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?
Title: Does the Blood-Brain Barrier Integrity Change in Regard to the Onset of Fetal Growth Restriction?

Submit: New GeneRIF Correction See all GeneRIFs (180)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The exposure to HIV-1 or HIV-1 gp120 results in a significant downregulation of tight junction proteins ZO-1, Occludin, Claudin-1, Claudin-2, Claudin-3, Claudin-4, and Claudin-5 in human retinal pigment epithelial cells	PubMed
	env	HIV-1 JRFL and HXB2 Env (gp120) downregulates TJP1(ZO-1) upon interaction with DC-SIGN in ARPE-19 cells and is dependent upon MMP activation	PubMed
	env	HIV-1 gp120-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human papillomavirus or herpes simplex virus	PubMed
	env	Treatment of cultured human brain endothelial cells with HIV-1 gp120 results in increased permeability of the endothelial monolayer and causes disruption and downregulation of the tight junction proteins ZO-1, ZO-2, and occludin in these cells	PubMed
	env	The expression of tight junction (TJ) proteins ZO-1, JAM-2, Occludin, Claudin-3 and Claudin-5 is modulated by HIV-1 gp120, and the modulated TJ expression involves Rho-A activation	PubMed
	env	Cannabinoid inhibits HIV-1 gp120-induced tight junction protein down-regulation of ZO-1, claudin-5, and JAM-1 in human brain micro vascular endothelial cells (HBMEC)	PubMed
Nef	nef	Exogenous Nef taken up by Caco-2 cells increases intestinal epithelial permeability, inhibits the IFN-gamma-induced reduction of transepitelial resistance and decreases the tight junction proteins occludin and ZO1 expression	PubMed
Tat	tat	Downregulation of ZO-1 by treatment with HIV-1 Tat and cocaine is inhibited by VEGFR-2 or sigma receptor antagonists, suggesting that VEGFR-2 and sigma receptor are involved in the downregulation of ZO-1 by Tat and cocaine in pulmonary cells	PubMed
	tat	Blocking HIV-1 Tat and cocaine-mediated Erk activation reverses ZO-1 downregulation in human pulmonary artery endothelial cells	PubMed
	tat	HIV-1 Tat-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human herpes simplex virus	PubMed
	tat	The function and activity of CREB is required for both Tat-induced Rho signaling and nuclear targeting of ZO-1	PubMed
	tat	Treatment of a brain endothelial cell line with HIV-1 Tat results in a decrease in total levels of ZO-1 but significantly upregulate ZO-1 protein expression in the nuclei	PubMed
	tat	Exposure to Tat diminishes the expression of several tight junction proteins, including occludin, zonula occludens (ZO)-1, and ZO-2 in the caveolar fraction of human brain micro vascular endothelial cells	PubMed
	tat	HIV-1 Tat-mediated tight junction disruption such as a diffuse cytoplasmic ZO-1 pattern facilitates paracellular penetration of mucosal epithelium by human papillomavirus	PubMed
	tat	HIV-1 Tat B disrupts blood-brain barrier (BBB) integrity to a greater extent compared to HIV-1 Tat C. This BBB dysfunction is associated with modulated expression of tight junction proteins zona occuldens (ZO-1) and junctional adhesion molecule (JAM)-2	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

G65615 (e-PCR)
- UniSTS:225551

TJP1_732 (e-PCR)
- UniSTS:277819

SHGC-31313 (e-PCR)
- UniSTS:51027

EST10C1 (e-PCR)
- UniSTS:263026

RH48761 (e-PCR)
- UniSTS:53877

WI-20235 (e-PCR)
- UniSTS:13944

STS-L14837 (e-PCR)
- UniSTS:2427

A004N26 (e-PCR)
- UniSTS:46768

G10656 (e-PCR)
- UniSTS:70582

TJP1 (e-PCR)
- UniSTS:479948

TJP1 (e-PCR)
- UniSTS:266199

SGC32975 (e-PCR)
- UniSTS:65762

WIAF-2543 (e-PCR)
- UniSTS:37617

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding	HDA more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actomyosin structure organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ameloblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stress fiber assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood-brain barrier permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood-brain barrier permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to bicellular tight junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to cell-cell junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	TAS Traceable Author Statement more info	PubMed
located_in apical junction complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	TAS Traceable Author Statement more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in podosome	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: tight junction protein ZO-1

Names: zona occludens 1; zonula occludens 1 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301025.3 → NP_001287954.2 tight junction protein ZO-1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is longer than isoform a. The exon combination of this variant is inferred based on partial transcript alignments.

Source sequence(s)

AC022613, AC087455, AF035298

Consensus CDS

CCDS91971.1

UniProtKB/TrEMBL

A9CQZ8, G3V1L9

Related

ENSP00000348416.7, ENST00000356107.11

Conserved Domains (8) summary

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1728 → 1827

ZU5; ZU5 domain

cl27975
Location:947 → 1342

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

cl28087
Location:1228 → 1688

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_001301026.2 → NP_001287955.1 tight junction protein ZO-1 isoform d

See identical proteins and their annotated locations for NP_001287955.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, and it lacks an alternate in-frame exon in the central coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AB370197, AC022613, AF035298, BX640879

Consensus CDS

CCDS73702.1

UniProtKB/TrEMBL

G5E9E7, Q6MZU1

Related

ENSP00000382890.2, ENST00000400011.6

Conserved Domains (7) summary

cd12026
Location:521 → 585

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:619 → 798

GuKc; Guanylate kinase homologues

smart00228
Location:187 → 267

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:26 → 111

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:429 → 505

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1558 → 1656

ZU5; ZU5 domain

pfam07223
Location:869 → 1174

DUF1421; Protein of unknown function (DUF1421)
NM_001330239.4 → NP_001317168.1 tight junction protein ZO-1 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (e) is longer than isoform a.

Source sequence(s)

AC022613

Consensus CDS

CCDS81858.1

UniProtKB/TrEMBL

A0A087X0K9, A9CQZ8

Related

ENSP00000483470.2, ENST00000614355.5

Conserved Domains (7) summary

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1634 → 1732

ZU5; ZU5 domain

pfam07223
Location:922 → 1250

DUF1421; Protein of unknown function (DUF1421)
NM_001355012.2 → NP_001341941.1 tight junction protein ZO-1 isoform f

Status: REVIEWED

Source sequence(s)

AA101028, AC022613, AC087455, AF035298, AL707462, BC111712, BE082525, BE819398, BI914113, BM459712, BQ434619, BQ575449, BX504167, BX640879, CD653673, CN372462, CN372473, CV571135, DB089107, HY197781

UniProtKB/TrEMBL

A9CQZ8

Conserved Domains (8) summary

smart00218
Location:1725 → 1831

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:518 → 594

PDZ; PDZ domain (Also known as DHR or GLGF)

cl27975
Location:947 → 1342

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

cl28087
Location:1228 → 1688

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_001355013.1 → NP_001341942.1 tight junction protein ZO-1 isoform g

Status: REVIEWED

Source sequence(s)

AC022613, AF035298, BC111712, BU618228, BX640879

UniProtKB/TrEMBL

A9CQZ8

Conserved Domains (8) summary

cd12026
Location:521 → 585

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:619 → 798

GuKc; Guanylate kinase homologues

smart00228
Location:187 → 267

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:26 → 111

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:429 → 505

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1639 → 1728

ZU5; ZU5 domain

cl27975
Location:858 → 1253

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

cl28087
Location:1139 → 1599

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_001355014.2 → NP_001341943.1 tight junction protein ZO-1 isoform h

Status: REVIEWED

Source sequence(s)

AC022613, AF035298, BC111712, BU618228, BX640879, L14837

UniProtKB/TrEMBL

A9CQZ8

Conserved Domains (8) summary

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1635 → 1724

ZU5; ZU5 domain

cl27975
Location:854 → 1249

EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

cl28087
Location:1135 → 1595

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_001355015.2 → NP_001341944.1 tight junction protein ZO-1 isoform i

Status: REVIEWED

Source sequence(s)

AC022613, AF035298, AK302971, BC111712, BM722482, BX640879, L14837

Consensus CDS

CCDS91970.1

UniProtKB/TrEMBL

A0A7I2V5U5, Q6MZU1

Related

ENSP00000504775.1, ENST00000677774.1

Conserved Domains (7) summary

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00791
Location:1555 → 1654

ZU5; ZU5 domain

cl28087
Location:1055 → 1515

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_003257.5 → NP_003248.3 tight junction protein ZO-1 isoform a

See identical proteins and their annotated locations for NP_003248.3

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as ZO-1alpha+) encodes isoform a, which is found in most epithelial cell junctions.

Source sequence(s)

AC022613, AF035298, BC111712, BX640879, L14837

Consensus CDS

CCDS42007.1

UniProtKB/Swiss-Prot

B4E3K1, Q07157, Q2NKP3, Q4ZGJ6

UniProtKB/TrEMBL

A9CQZ8

Related

ENSP00000281537.7, ENST00000346128.10

Conserved Domains (7) summary

smart00218
Location:1632 → 1738

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam07223
Location:922 → 1250

DUF1421; Protein of unknown function (DUF1421)
NM_175610.4 → NP_783297.2 tight junction protein ZO-1 isoform b

See identical proteins and their annotated locations for NP_783297.2

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as ZO-1alpha-) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. Isoform b is found in both endothelial cells and the highly specialized epithelial junctions of renal glomeruli and sertoli cells of the seminiferous tubules. The exon combination of this variant is inferred based on partial transcript alignments and data in PMID:1590354.

Source sequence(s)

AC022613, AF035298, AK302971, BC111712, BX640879, L14837

Consensus CDS

CCDS45199.1

UniProtKB/TrEMBL

Q6MZU1

Related

ENSP00000441202.2, ENST00000545208.6

Conserved Domains (7) summary

smart00218
Location:1552 → 1658

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:517 → 581

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:615 → 794

GuKc; Guanylate kinase homologues

smart00228
Location:183 → 263

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:22 → 107

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00595
Location:425 → 501

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam07223
Location:865 → 1170

DUF1421; Protein of unknown function (DUF1421)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

29699367..29969049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005254620.4 → XP_005254677.2 tight junction protein ZO-1 isoform X14

UniProtKB/TrEMBL

Q6MZU1

Conserved Domains (6) summary

smart00218
Location:1645 → 1751

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd12026
Location:610 → 674

SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1

smart00072
Location:708 → 887

GuKc; Guanylate kinase homologues

smart00228
Location:276 → 356

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PRK10263
Location:1148 → 1608

PRK10263; DNA translocase FtsK; Provisional

cd00992
Location:115 → 200

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
XM_047432984.1 → XP_047288940.1 tight junction protein ZO-1 isoform X13
XM_005254619.4 → XP_005254676.2 tight junction protein ZO-1 isoform X9

UniProtKB/TrEMBL

Q6MZU1
XM_047432981.1 → XP_047288937.1 tight junction protein ZO-1 isoform X10
XM_017022524.2 → XP_016878013.1 tight junction protein ZO-1 isoform X5

UniProtKB/TrEMBL

Q6MZU1
XM_011521972.3 → XP_011520274.2 tight junction protein ZO-1 isoform X4

UniProtKB/TrEMBL

A9CQZ8
XM_017022523.2 → XP_016878012.1 tight junction protein ZO-1 isoform X3

UniProtKB/TrEMBL

A9CQZ8
XM_017022522.2 → XP_016878011.1 tight junction protein ZO-1 isoform X2

UniProtKB/TrEMBL

A9CQZ8
XM_017022521.2 → XP_016878010.1 tight junction protein ZO-1 isoform X1

UniProtKB/TrEMBL

A9CQZ8
XM_047432990.1 → XP_047288946.1 tight junction protein ZO-1 isoform X20
XM_047432989.1 → XP_047288945.1 tight junction protein ZO-1 isoform X19
XM_047432988.1 → XP_047288944.1 tight junction protein ZO-1 isoform X18
XM_047432986.1 → XP_047288942.1 tight junction protein ZO-1 isoform X16
XM_047432983.1 → XP_047288939.1 tight junction protein ZO-1 isoform X12
XM_017022526.2 → XP_016878015.1 tight junction protein ZO-1 isoform X7

UniProtKB/TrEMBL

A9CQZ8
XM_047432987.1 → XP_047288943.1 tight junction protein ZO-1 isoform X17

UniProtKB/TrEMBL

G5E9E7
XM_047432985.1 → XP_047288941.1 tight junction protein ZO-1 isoform X15
XM_017022525.2 → XP_016878014.1 tight junction protein ZO-1 isoform X6

UniProtKB/TrEMBL

A9CQZ8
XM_047432991.1 → XP_047288947.1 tight junction protein ZO-1 isoform X21
XM_017022527.2 → XP_016878016.1 tight junction protein ZO-1 isoform X8

UniProtKB/TrEMBL

A9CQZ8
XM_047432982.1 → XP_047288938.1 tight junction protein ZO-1 isoform X11

Reference GRCh38.p14 PATCHES

Genomic

NW_011332701.1 Reference GRCh38.p14 PATCHES

Range

1871012..2141730 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331832.1 → XP_054187807.1 tight junction protein ZO-1 isoform X14
XM_054331829.1 → XP_054187804.1 tight junction protein ZO-1 isoform X13
XM_054331826.1 → XP_054187801.1 tight junction protein ZO-1 isoform X9
XM_054331827.1 → XP_054187802.1 tight junction protein ZO-1 isoform X10
XM_054331824.1 → XP_054187799.1 tight junction protein ZO-1 isoform X22
XM_054331821.1 → XP_054187796.1 tight junction protein ZO-1 isoform X5
XM_054331820.1 → XP_054187795.1 tight junction protein ZO-1 isoform X4
XM_054331819.1 → XP_054187794.1 tight junction protein ZO-1 isoform X3
XM_054331818.1 → XP_054187793.1 tight junction protein ZO-1 isoform X2
XM_054331817.1 → XP_054187792.1 tight junction protein ZO-1 isoform X1
XM_054331831.1 → XP_054187806.1 tight junction protein ZO-1 isoform X24
XM_054331842.1 → XP_054187817.1 tight junction protein ZO-1 isoform X20
XM_054331840.1 → XP_054187815.1 tight junction protein ZO-1 isoform X19
XM_054331838.1 → XP_054187813.1 tight junction protein ZO-1 isoform X18
XM_054331836.1 → XP_054187811.1 tight junction protein ZO-1 isoform X16
XM_054331823.1 → XP_054187798.1 tight junction protein ZO-1 isoform X7
XM_054331844.1 → XP_054187819.1 tight junction protein ZO-1 isoform X30
XM_054331837.1 → XP_054187812.1 tight junction protein ZO-1 isoform X17

UniProtKB/TrEMBL

G5E9E7
XM_054331835.1 → XP_054187810.1 tight junction protein ZO-1 isoform X26
XM_054331833.1 → XP_054187808.1 tight junction protein ZO-1 isoform X15
XM_054331822.1 → XP_054187797.1 tight junction protein ZO-1 isoform X6
XM_054331843.1 → XP_054187818.1 tight junction protein ZO-1 isoform X29
XM_054331839.1 → XP_054187814.1 tight junction protein ZO-1 isoform X27
XM_054331825.1 → XP_054187800.1 tight junction protein ZO-1 isoform X8
XM_054331830.1 → XP_054187805.1 tight junction protein ZO-1 isoform X23
XM_054331845.1 → XP_054187820.1 tight junction protein ZO-1 isoform X21
XM_054331846.1 → XP_054187821.1 tight junction protein ZO-1 isoform X31
XM_054331841.1 → XP_054187816.1 tight junction protein ZO-1 isoform X28

UniProtKB/TrEMBL

A0A0G2JNH2
XM_054331834.1 → XP_054187809.1 tight junction protein ZO-1 isoform X25
XM_054331828.1 → XP_054187803.1 tight junction protein ZO-1 isoform X11

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

1983496..2254214 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330059.1 → XP_054186034.1 tight junction protein ZO-1 isoform X14
XM_054330056.1 → XP_054186031.1 tight junction protein ZO-1 isoform X13
XM_054330053.1 → XP_054186028.1 tight junction protein ZO-1 isoform X9
XM_054330054.1 → XP_054186029.1 tight junction protein ZO-1 isoform X10
XM_054330051.1 → XP_054186026.1 tight junction protein ZO-1 isoform X22
XM_054330048.1 → XP_054186023.1 tight junction protein ZO-1 isoform X5
XM_054330047.1 → XP_054186022.1 tight junction protein ZO-1 isoform X4
XM_054330046.1 → XP_054186021.1 tight junction protein ZO-1 isoform X3
XM_054330045.1 → XP_054186020.1 tight junction protein ZO-1 isoform X2
XM_054330044.1 → XP_054186019.1 tight junction protein ZO-1 isoform X1
XM_054330058.1 → XP_054186033.1 tight junction protein ZO-1 isoform X24
XM_054330069.1 → XP_054186044.1 tight junction protein ZO-1 isoform X20
XM_054330067.1 → XP_054186042.1 tight junction protein ZO-1 isoform X19
XM_054330065.1 → XP_054186040.1 tight junction protein ZO-1 isoform X18
XM_054330063.1 → XP_054186038.1 tight junction protein ZO-1 isoform X16
XM_054330050.1 → XP_054186025.1 tight junction protein ZO-1 isoform X7
XM_054330071.1 → XP_054186046.1 tight junction protein ZO-1 isoform X30
XM_054330064.1 → XP_054186039.1 tight junction protein ZO-1 isoform X17

UniProtKB/TrEMBL

G5E9E7
XM_054330062.1 → XP_054186037.1 tight junction protein ZO-1 isoform X26
XM_054330060.1 → XP_054186035.1 tight junction protein ZO-1 isoform X15
XM_054330049.1 → XP_054186024.1 tight junction protein ZO-1 isoform X6
XM_054330070.1 → XP_054186045.1 tight junction protein ZO-1 isoform X29
XM_054330066.1 → XP_054186041.1 tight junction protein ZO-1 isoform X27
XM_054330052.1 → XP_054186027.1 tight junction protein ZO-1 isoform X8
XM_054330057.1 → XP_054186032.1 tight junction protein ZO-1 isoform X23
XM_054330072.1 → XP_054186047.1 tight junction protein ZO-1 isoform X21
XM_054330073.1 → XP_054186048.1 tight junction protein ZO-1 isoform X31
XM_054330068.1 → XP_054186043.1 tight junction protein ZO-1 isoform X28

UniProtKB/TrEMBL

A0A0G2JNH2
XM_054330061.1 → XP_054186036.1 tight junction protein ZO-1 isoform X25
XM_054330055.1 → XP_054186030.1 tight junction protein ZO-1 isoform X11

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

27490136..27760675 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054378703.1 → XP_054234678.1 tight junction protein ZO-1 isoform X14
XM_054378700.1 → XP_054234675.1 tight junction protein ZO-1 isoform X13
XM_054378696.1 → XP_054234671.1 tight junction protein ZO-1 isoform X9
XM_054378697.1 → XP_054234672.1 tight junction protein ZO-1 isoform X10
XM_054378694.1 → XP_054234669.1 tight junction protein ZO-1 isoform X32
XM_054378691.1 → XP_054234666.1 tight junction protein ZO-1 isoform X5
XM_054378690.1 → XP_054234665.1 tight junction protein ZO-1 isoform X4
XM_054378689.1 → XP_054234664.1 tight junction protein ZO-1 isoform X3
XM_054378688.1 → XP_054234663.1 tight junction protein ZO-1 isoform X2
XM_054378687.1 → XP_054234662.1 tight junction protein ZO-1 isoform X1
XM_054378702.1 → XP_054234677.1 tight junction protein ZO-1 isoform X34
XM_054378713.1 → XP_054234688.1 tight junction protein ZO-1 isoform X20
XM_054378711.1 → XP_054234686.1 tight junction protein ZO-1 isoform X19
XM_054378709.1 → XP_054234684.1 tight junction protein ZO-1 isoform X18
XM_054378707.1 → XP_054234682.1 tight junction protein ZO-1 isoform X16
XM_054378699.1 → XP_054234674.1 tight junction protein ZO-1 isoform X12
XM_054378693.1 → XP_054234668.1 tight junction protein ZO-1 isoform X7
XM_054378715.1 → XP_054234690.1 tight junction protein ZO-1 isoform X40
XM_054378708.1 → XP_054234683.1 tight junction protein ZO-1 isoform X17

UniProtKB/TrEMBL

G5E9E7
XM_054378706.1 → XP_054234681.1 tight junction protein ZO-1 isoform X36
XM_054378704.1 → XP_054234679.1 tight junction protein ZO-1 isoform X15
XM_054378692.1 → XP_054234667.1 tight junction protein ZO-1 isoform X6
XM_054378716.1 → XP_054234691.1 tight junction protein ZO-1 isoform X21
XM_054378714.1 → XP_054234689.1 tight junction protein ZO-1 isoform X39
XM_054378710.1 → XP_054234685.1 tight junction protein ZO-1 isoform X37
XM_054378695.1 → XP_054234670.1 tight junction protein ZO-1 isoform X8
XM_054378701.1 → XP_054234676.1 tight junction protein ZO-1 isoform X33
XM_054378717.1 → XP_054234692.1 tight junction protein ZO-1 isoform X41
XM_054378712.1 → XP_054234687.1 tight junction protein ZO-1 isoform X38

UniProtKB/TrEMBL

A0A0G2JNH2
XM_054378705.1 → XP_054234680.1 tight junction protein ZO-1 isoform X35
XM_054378698.1 → XP_054234673.1 tight junction protein ZO-1 isoform X11