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    Mocs3 molybdenum cofactor synthesis 3 [ Mus musculus (house mouse) ]

    Gene ID: 69372, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mocs3provided by MGI
    Official Full Name
    molybdenum cofactor synthesis 3provided by MGI
    Primary source
    MGI:MGI:1916622
    See related
    Ensembl:ENSMUSG00000074576 AllianceGenome:MGI:1916622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Uba4; 1700020H17Rik
    Summary
    Predicted to enable URM1 activating enzyme activity; nucleotidyltransferase activity; and sulfurtransferase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process; protein urmylation; and tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Orthologous to human MOCS3 (molybdenum cofactor synthesis 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See Mocs3 in Genome Data Viewer
    Location:
    2 H3; 2 88.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168072542..168074223)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168230622..168232303)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 20716 Neighboring gene activity-dependent neuroprotective protein Neighboring gene STARR-seq mESC enhancer starr_06457 Neighboring gene STARR-positive B cell enhancer ABC_E10163 Neighboring gene STARR-positive B cell enhancer ABC_E8797 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 1, catalytic Neighboring gene STARR-seq mESC enhancer starr_06458 Neighboring gene 28S ribosomal protein S18c, mitochondrial pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:168075791-168076092 Neighboring gene potassium voltage-gated channel, subfamily G, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The L-cysteine desulfurase NFS1 is localized in the cytosol where it provides the sulfur for molybdenum cofactor biosynthesis in humans. Marelja Z, et al. PLoS One, 2013. PMID 23593335, Free PMC Article
    2. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables URM1 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables URM1 activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables URM1 activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin-synthase adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin-synthase sulfurtransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molybdopterin-synthase sulfurtransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sulfurtransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables sulfurtransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Mo-molybdopterin cofactor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in molybdopterin cofactor metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein urmylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA thio-modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA thio-modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA wobble uridine modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adenylyltransferase and sulfurtransferase MOCS3
    Names
    MPT synthase sulfurylase
    NP_001153802.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160330.1 → NP_001153802.1  adenylyltransferase and sulfurtransferase MOCS3

      See identical proteins and their annotated locations for NP_001153802.1

      Status: VALIDATED

      Source sequence(s)
      BE133066, BE333092, BG083535, BX005039, BY727851
      Consensus CDS
      CCDS50802.1
      UniProtKB/Swiss-Prot
      A2BDX3
      Related
      ENSMUSP00000096670.4, ENSMUST00000099071.5
      Conserved Domains (3) summary
      PRK07411
      Location:56 → 460
      PRK07411; hypothetical protein; Validated
      cd00757
      Location:62 → 285
      ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...
      cd01526
      Location:327 → 460
      RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      168072542..168074223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2BDX3.1 GenPept UniProtKB/Swiss-Prot:A2BDX3

    Gene LinkOut

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