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    ARHGEF35 Rho guanine nucleotide exchange factor 35 [ Homo sapiens (human) ]

    Gene ID: 445328, updated on 17-Sep-2024

    Summary

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    Official Symbol
    ARHGEF35provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 35provided by HGNC
    Primary source
    HGNC:HGNC:33846
    See related
    Ensembl:ENSG00000213214 AllianceGenome:HGNC:33846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARHGEF5L
    Expression
    Broad expression in thyroid (RPKM 25.8), colon (RPKM 15.5) and 22 other tissues See more
    Orthologs
    all
    NEW
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    Genomic context

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    See ARHGEF35 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144186083..144195879, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145466560..145476351, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143883176..143892972, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AO member 1 pseudogene Neighboring gene ARHGEF35 antisense RNA 1 Neighboring gene CTAGE family member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143901531-143902093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143902094-143902655 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:143904530-143905158 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143905159-143905786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143906415-143907042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:143935567-143936068 Neighboring gene olfactory receptor family 2 subfamily A member 42 Neighboring gene OR2A1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:143947746-143948246 Neighboring gene olfactory receptor family 2 subfamily A member 20 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transcriptional fates of human-specific segmental duplications in brain. Dougherty ML, et al. Genome Res, 2018 Oct. PMID 30228200, Free PMC Article
    2. Lineage-specific gene duplication and loss in human and great ape evolution. Fortna A, et al. PLoS Biol, 2004 Jul. PMID 15252450, Free PMC Article
    3. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, et al. Cell Rep, 2017 Jul 11. PMID 28700943, Free PMC Article
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
    5. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D). Kennedy SA, et al. Nat Commun, 2020 Jan 24. PMID 31980649, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ43692

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 35
    Names
    Rho guanine nucleotide exchange factor (GEF) 35
    rho guanine nucleotide exchange factor 5-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003702.3 → NP_001003702.2  rho guanine nucleotide exchange factor 35

      See identical proteins and their annotated locations for NP_001003702.2

      Status: VALIDATED

      Source sequence(s)
      AC004889
      Consensus CDS
      CCDS34770.1
      UniProtKB/Swiss-Prot
      A5YM69, Q6ZUI2
      UniProtKB/TrEMBL
      A0A5F9ZGZ6
      Related
      ENSP00000367355.3, ENST00000378115.3
      Conserved Domains (1) summary
      pfam15441
      Location:1 → 478
      ARHGEF5_35; Rho guanine nucleotide exchange factor 5/35

    2. NM_001368318.1 → NP_001355247.1  rho guanine nucleotide exchange factor 35

      Status: VALIDATED

      Source sequence(s)
      MH721903
      Consensus CDS
      CCDS34770.1
      UniProtKB/Swiss-Prot
      A5YM69, Q6ZUI2
      UniProtKB/TrEMBL
      A0A5F9ZGZ6
      Related
      ENSP00000510684.1, ENST00000688754.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      144186083..144195879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654715.1 Reference GRCh38.p14 PATCHES

      Range
      140648..150440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332180.1 → XP_054188155.1  rho guanine nucleotide exchange factor 35 isoform X1

      UniProtKB/TrEMBL
      A0A5F9ZGZ6, A0A5F9ZH52

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      145466560..145476351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358266.1 → XP_054214241.1  rho guanine nucleotide exchange factor 35 isoform X1

      UniProtKB/TrEMBL
      A0A5F9ZGZ6, A0A5F9ZH52
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A5YM69.1 GenPept UniProtKB/Swiss-Prot:A5YM69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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