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    GOLGA8J golgin A8 family member J [ Homo sapiens (human) ]

    Gene ID: 653073, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GOLGA8Jprovided by HGNC
    Official Full Name
    golgin A8 family member Jprovided by HGNC
    Primary source
    HGNC:HGNC:38650
    See related
    Ensembl:ENSG00000179938 AllianceGenome:HGNC:38650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thyroid (RPKM 10.8), testis (RPKM 10.1) and 24 other tissues See more
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    Genomic context

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    See GOLGA8J in Genome Data Viewer
    Location:
    15q13.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (30082955..30096690)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (27874675..27888411)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (30375158..30388893)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene non-SMC condensin I complex subunit G pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:30318078-30318268 Neighboring gene synaptogyrin 2 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:30375577-30376156 Neighboring gene RNA, 7SL, cytoplasmic 673, pseudogene Neighboring gene dynamin 1 pseudogene 28 Neighboring gene U8 small nucleolar RNA Neighboring gene ULK4 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171
    2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
    3. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ52611

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 8J
    Names
    Golgin subfamily A member 8-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282472.2 → NP_001269401.1  golgin subfamily A member 8J

      See identical proteins and their annotated locations for NP_001269401.1

      Status: VALIDATED

      Source sequence(s)
      AC120045, DB054802, DB098469
      Consensus CDS
      CCDS61574.1
      UniProtKB/Swiss-Prot
      A6NMD2, H3BRU0
      UniProtKB/TrEMBL
      A0A1B0GVY7
      Related
      ENSP00000456401.1, ENST00000567927.2
      Conserved Domains (1) summary
      pfam15070
      Location:226 → 621
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      30082955..30096690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521950.3 → XP_011520252.1  golgin subfamily A member 8J isoform X3

      See identical proteins and their annotated locations for XP_011520252.1

      Conserved Domains (2) summary
      COG1196
      Location:86 → 325
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15070
      Location:226 → 449
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    2. XM_006720651.4 → XP_006720714.1  golgin subfamily A member 8J isoform X1

      See identical proteins and their annotated locations for XP_006720714.1

      UniProtKB/TrEMBL
      A0A1B0GVY7
      Conserved Domains (1) summary
      pfam15070
      Location:213 → 608
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    3. XM_047432963.1 → XP_047288919.1  golgin subfamily A member 8J isoform X2

    RNA

    1. XR_002957674.2 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332701.1 Reference GRCh38.p14 PATCHES

      Range
      2255675..2269410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331807.1 → XP_054187782.1  golgin subfamily A member 8J isoform X3

    2. XM_054331805.1 → XP_054187780.1  golgin subfamily A member 8J isoform X1

    3. XM_054331806.1 → XP_054187781.1  golgin subfamily A member 8J isoform X2

    RNA

    1. XR_008485735.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_012132920.1 Reference GRCh38.p14 PATCHES

      Range
      70634..84357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      2368159..2381894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330035.1 → XP_054186010.1  golgin subfamily A member 8J isoform X3

    2. XM_054330033.1 → XP_054186008.1  golgin subfamily A member 8J isoform X1

    3. XM_054330034.1 → XP_054186009.1  golgin subfamily A member 8J isoform X2

    RNA

    1. XR_008485669.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      27874675..27888411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378655.1 → XP_054234630.1  golgin subfamily A member 8J isoform X4

    2. XM_054378656.1 → XP_054234631.1  golgin subfamily A member 8J isoform X3

    3. XM_054378654.1 → XP_054234629.1  golgin subfamily A member 8J isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NMD2.3 GenPept UniProtKB/Swiss-Prot:A6NMD2

    Gene LinkOut

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