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    ABLIM1 actin binding LIM protein 1 [ Homo sapiens (human) ]

    Gene ID: 3983, updated on 3-Nov-2024

    Summary

    Official Symbol
    ABLIM1provided by HGNC
    Official Full Name
    actin binding LIM protein 1provided by HGNC
    Primary source
    HGNC:HGNC:78
    See related
    Ensembl:ENSG00000099204 MIM:602330; AllianceGenome:HGNC:78
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ABLIM; LIMAB1; LIMATIN; abLIM-1
    Summary
    This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2017]
    Expression
    Ubiquitous expression in ovary (RPKM 50.7), heart (RPKM 50.1) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ABLIM1 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (114431110..114801373, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (115325183..115686686, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116190869..116528063, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116079781-116080980 Neighboring gene uncharacterized LOC105378494 Neighboring gene actin filament associated protein 1 like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:116088199-116088844 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116097011-116098210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116110152-116111044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116164296-116164796 Neighboring gene RNA, 7SL, cytoplasmic 384, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116219699-116220200 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:116247470-116248669 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:116249579-116250078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4083 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:116259001-116260200 Neighboring gene Sharpr-MPRA regulatory region 9264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116278667-116279186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4088 Neighboring gene Sharpr-MPRA regulatory region 11198 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:116471523-116472022 Neighboring gene peptidylprolyl isomerase A pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116514326-116514855 Neighboring gene uncharacterized LOC101927692 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4091 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2847 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:116581943-116582443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4092 Neighboring gene TATA-box binding protein associated factor 9b pseudogene 2 Neighboring gene FHF complex subunit HOOK interacting protein 2A Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:116640543-116641171

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC1224, FLJ14564, KIAA0059, DKFZp781D0148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual perception TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    actin-binding LIM protein 1
    Names
    actin-binding LIM protein family member 1
    actin-binding double-zinc-finger protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029872.2 RefSeqGene

      Range
      168369..395532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003407.2NP_001003407.1  actin-binding LIM protein 1 isoform b

      See identical proteins and their annotated locations for NP_001003407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (b) contains a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AL133384, AL354873, AW627433, D31883
      Consensus CDS
      CCDS31288.1
      UniProtKB/TrEMBL
      F8W8M4
      Related
      ENSP00000376682.4, ENST00000392955.8
      Conserved Domains (7) summary
      smart00153
      Location:683718
      VHP; Villin headpiece domain
      cd09327
      Location:3990
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:290682
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:520580
      Rifin_STEVOR; Rifin/stevor family
    2. NM_001322882.2NP_001309811.1  actin-binding LIM protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (d) has a shorter, distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK122891, AL133384, AL354873
      Consensus CDS
      CCDS81509.1
      UniProtKB/TrEMBL
      F8W8M4
      Related
      ENSP00000358260.3, ENST00000369256.6
      Conserved Domains (7) summary
      smart00153
      Location:713748
      VHP; Villin headpiece domain
      cd09327
      Location:3990
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:318712
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:550610
      Rifin_STEVOR; Rifin/stevor family
    3. NM_001322883.2NP_001309812.1  actin-binding LIM protein 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL354873
      UniProtKB/TrEMBL
      F8W8M4
    4. NM_001322884.3NP_001309813.1  actin-binding LIM protein 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL137025, AL354873
      UniProtKB/TrEMBL
      F8W8M4
    5. NM_001322885.3NP_001309814.1  actin-binding LIM protein 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL137025, AL354873
      UniProtKB/TrEMBL
      F8W8M4
    6. NM_001322886.3NP_001309815.1  actin-binding LIM protein 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL137025, AL354873
      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (6) summary
      smart00153
      Location:619654
      VHP; Villin headpiece domain
      cd09327
      Location:2273
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:78133
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:149200
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:208263
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:272617
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    7. NM_001322887.2NP_001309816.1  actin-binding LIM protein 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL354873
      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (7) summary
      smart00153
      Location:601636
      VHP; Villin headpiece domain
      cd09327
      Location:3990
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:289599
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:400498
      RIFIN; Rifin
    8. NM_001322888.2NP_001309817.1  actin-binding LIM protein 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL133384
      Conserved Domains (3) summary
      smart00153
      Location:420455
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33418
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    9. NM_001322889.2NP_001309818.1  actin-binding LIM protein 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL133384
    10. NM_001322890.2NP_001309819.1  actin-binding LIM protein 1 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) and variant 14 both encode isoform l.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:394429
      VHP; Villin headpiece domain
      pfam16182
      Location:34393
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:231291
      Rifin_STEVOR; Rifin/stevor family
    11. NM_001322891.2NP_001309820.1  actin-binding LIM protein 1 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) and variant 13 both encode isoform l.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:394429
      VHP; Villin headpiece domain
      pfam16182
      Location:34393
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:231291
      Rifin_STEVOR; Rifin/stevor family
    12. NM_001322892.2NP_001309821.1  actin-binding LIM protein 1 isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) and variant 16 both encode isoform n.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:392427
      VHP; Villin headpiece domain
      pfam16182
      Location:34391
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:229289
      Rifin_STEVOR; Rifin/stevor family
    13. NM_001322893.2NP_001309822.1  actin-binding LIM protein 1 isoform n

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) and variant 15 both encode isoform n.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:392427
      VHP; Villin headpiece domain
      pfam16182
      Location:34391
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:229289
      Rifin_STEVOR; Rifin/stevor family
    14. NM_001322894.2NP_001309823.1  actin-binding LIM protein 1 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) and variant 18 both encode isoform o.
      Source sequence(s)
      AL133384
      Conserved Domains (3) summary
      smart00153
      Location:380415
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33378
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    15. NM_001322895.2NP_001309824.1  actin-binding LIM protein 1 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) and variant 17 both encode isoform o.
      Source sequence(s)
      AL133384
      Conserved Domains (3) summary
      smart00153
      Location:380415
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33378
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    16. NM_001322896.2NP_001309825.1  actin-binding LIM protein 1 isoform p

      Status: REVIEWED

      Source sequence(s)
      AL133384, BC002448
      Consensus CDS
      CCDS81508.1
      UniProtKB/Swiss-Prot
      O14639
      Related
      ENSP00000358257.2, ENST00000369253.6
      Conserved Domains (2) summary
      smart00153
      Location:366401
      VHP; Villin headpiece domain
      pfam16182
      Location:8365
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    17. NM_001322897.2NP_001309826.1  actin-binding LIM protein 1 isoform q

      Status: REVIEWED

      Source sequence(s)
      AL133384
      Conserved Domains (2) summary
      smart00153
      Location:354389
      VHP; Villin headpiece domain
      pfam16182
      Location:8353
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    18. NM_001322898.2NP_001309827.1  actin-binding LIM protein 1 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) and variant 22 both encode isoform r.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B4DQA3
      Conserved Domains (4) summary
      smart00153
      Location:345380
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33343
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:144242
      RIFIN; Rifin
    19. NM_001322899.2NP_001309828.1  actin-binding LIM protein 1 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) and variant 21 both encode isoform r.
      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B4DQA3
      Conserved Domains (4) summary
      smart00153
      Location:345380
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:33343
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:144242
      RIFIN; Rifin
    20. NM_001322900.2NP_001309829.1  actin-binding LIM protein 1 isoform t

      Status: REVIEWED

      Source sequence(s)
      AL133384
      Conserved Domains (2) summary
      smart00153
      Location:319354
      VHP; Villin headpiece domain
      pfam16182
      Location:8318
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    21. NM_001352440.1NP_001339369.1  actin-binding LIM protein 1 isoform u

      Status: REVIEWED

      Source sequence(s)
      AK297344, AL133384, AL354873, DC376979
      UniProtKB/TrEMBL
      A0A494C1G0, B7Z4H1, F8W8M4
      Related
      ENSP00000499023.2, ENST00000651023.2
      Conserved Domains (6) summary
      smart00153
      Location:620655
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273618
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    22. NM_001352441.1NP_001339370.1  actin-binding LIM protein 1 isoform v

      Status: REVIEWED

      Source sequence(s)
      AL133384, AL354873, DC376979
      UniProtKB/TrEMBL
      A0A9L9PY99, F8W8M4
      Related
      ENSP00000516747.1, ENST00000707119.1
      Conserved Domains (7) summary
      smart00153
      Location:585620
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:273583
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:384482
      RIFIN; Rifin
    23. NM_001352442.2NP_001339371.1  actin-binding LIM protein 1 isoform w

      Status: REVIEWED

      Source sequence(s)
      AK093471, AL133384, AL354873, DB039901
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (5) summary
      smart00153
      Location:556591
      VHP; Villin headpiece domain
      cd09328
      Location:358
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:198555
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    24. NM_001352443.2NP_001339372.1  actin-binding LIM protein 1 isoform x

      Status: REVIEWED

      Source sequence(s)
      AL133384
      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (3) summary
      smart00153
      Location:429464
      VHP; Villin headpiece domain
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      pfam16182
      Location:34428
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    25. NM_002313.7NP_002304.3  actin-binding LIM protein 1 isoform a

      See identical proteins and their annotated locations for NP_002304.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AF005654, AL133384, AL354873
      Consensus CDS
      CCDS7590.1
      UniProtKB/Swiss-Prot
      A6NI16, A6NJ06, A8MXA9, B3KVH2, O14639, Q15039, Q5JVV1, Q5JVV2, Q5T6N2, Q5T6N3, Q5T6N5, Q68CQ9, Q9BUP1
      UniProtKB/TrEMBL
      A0A2Z4N5U1
      Related
      ENSP00000433629.3, ENST00000533213.7
      Conserved Domains (7) summary
      smart00153
      Location:743778
      VHP; Villin headpiece domain
      cd09327
      Location:99150
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:155210
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:226277
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:285340
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:350742
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl14106
      Location:580640
      Rifin_STEVOR; Rifin/stevor family
    26. NM_006720.4NP_006711.3  actin-binding LIM protein 1 isoform s

      See identical proteins and their annotated locations for NP_006711.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR and has multiple differences in the coding region, compared to variant 1. It also uses a downstream start codon, compared to variant 1. The resulting isoform (s) is shorter, compared to isoform a.
      Source sequence(s)
      AI680726, AK058007, AK093471, AK122891, AL600892, AL710059, AW627433, BC002448, BE395092, BE672277, BG426037, BQ721521, CA450184, CB128609, CD558045, D31883
      Consensus CDS
      CCDS31289.1
      UniProtKB/TrEMBL
      B3KSG3
      Related
      ENSP00000376679.3, ENST00000392952.7
      Conserved Domains (4) summary
      smart00153
      Location:420455
      VHP; Villin headpiece domain
      pfam16182
      Location:62419
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:257317
      Rifin_STEVOR; Rifin/stevor family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      114431110..114801373 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425242.1XP_047281198.1  actin-binding LIM protein 1 isoform X24

    2. XM_047425238.1XP_047281194.1  actin-binding LIM protein 1 isoform X19

    3. XM_047425237.1XP_047281193.1  actin-binding LIM protein 1 isoform X18

    4. XM_047425239.1XP_047281195.1  actin-binding LIM protein 1 isoform X20

    5. XM_047425232.1XP_047281188.1  actin-binding LIM protein 1 isoform X11

    6. XM_047425231.1XP_047281187.1  actin-binding LIM protein 1 isoform X10

    7. XM_047425240.1XP_047281196.1  actin-binding LIM protein 1 isoform X21

    8. XM_017016247.2XP_016871736.2  actin-binding LIM protein 1 isoform X14

    9. XM_047425234.1XP_047281190.1  actin-binding LIM protein 1 isoform X13

    10. XM_047425236.1XP_047281192.1  actin-binding LIM protein 1 isoform X15

    11. XM_024448011.2XP_024303779.2  actin-binding LIM protein 1 isoform X4

    12. XM_047425229.1XP_047281185.1  actin-binding LIM protein 1 isoform X3

    13. XM_024448010.2XP_024303778.2  actin-binding LIM protein 1 isoform X1

    14. XM_017016255.2XP_016871744.1  actin-binding LIM protein 1 isoform X22

      UniProtKB/TrEMBL
      F8W8M4
    15. XM_017016250.2XP_016871739.1  actin-binding LIM protein 1 isoform X17

      UniProtKB/TrEMBL
      F8W8M4
    16. XM_017016245.2XP_016871734.1  actin-binding LIM protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A3B3IS55
    17. XM_047425243.1XP_047281199.1  actin-binding LIM protein 1 isoform X25

    18. XM_047425233.1XP_047281189.1  actin-binding LIM protein 1 isoform X12

    19. XM_006717837.3XP_006717900.1  actin-binding LIM protein 1 isoform X5

      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (6) summary
      smart00153
      Location:753788
      VHP; Villin headpiece domain
      cd09327
      Location:3990
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:95150
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:166217
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:225280
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:318752
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    20. XM_011539802.3XP_011538104.2  actin-binding LIM protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A3B3IS55
      Conserved Domains (6) summary
      smart00153
      Location:743778
      VHP; Villin headpiece domain
      cd09327
      Location:2980
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:85140
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:156207
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:215270
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:308742
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    21. XM_017016256.2XP_016871745.1  actin-binding LIM protein 1 isoform X26

      UniProtKB/TrEMBL
      F8W8M4
    22. XM_024448016.2XP_024303784.1  actin-binding LIM protein 1 isoform X16

      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (6) summary
      smart00153
      Location:709744
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:274708
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    23. XM_024448018.2XP_024303786.1  actin-binding LIM protein 1 isoform X23

      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (6) summary
      smart00153
      Location:662697
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:302661
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    24. XM_024448014.2XP_024303782.1  actin-binding LIM protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A3B3IS55
      Conserved Domains (6) summary
      smart00153
      Location:737772
      VHP; Villin headpiece domain
      cd09327
      Location:2374
      LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
      cd09328
      Location:79134
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:150201
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:209264
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:302736
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    25. XM_024448013.2XP_024303781.1  actin-binding LIM protein 1 isoform X7

      UniProtKB/TrEMBL
      F8W8M4
      Conserved Domains (5) summary
      smart00153
      Location:633668
      VHP; Villin headpiece domain
      cd09328
      Location:358
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:198632
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    26. XM_011539801.3XP_011538103.2  actin-binding LIM protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IS55
      Conserved Domains (5) summary
      smart00153
      Location:661696
      VHP; Villin headpiece domain
      cd09328
      Location:358
      LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
      cd09329
      Location:74125
      LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
      cd09330
      Location:133188
      LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
      pfam16182
      Location:226660
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    27. XM_006717846.4XP_006717909.1  actin-binding LIM protein 1 isoform X27

      See identical proteins and their annotated locations for XP_006717909.1

      UniProtKB/TrEMBL
      B3KSG3
      Conserved Domains (4) summary
      smart00153
      Location:497532
      VHP; Villin headpiece domain
      pfam16182
      Location:62496
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
      cl02475
      Location:124
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl14106
      Location:334394
      Rifin_STEVOR; Rifin/stevor family
    28. XM_047425245.1XP_047281201.1  actin-binding LIM protein 1 isoform X29

    29. XM_047425244.1XP_047281200.1  actin-binding LIM protein 1 isoform X28

    30. XM_047425246.1XP_047281202.1  actin-binding LIM protein 1 isoform X30

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      115325183..115686686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365923.1XP_054221898.1  actin-binding LIM protein 1 isoform X39

    2. XM_054365924.1XP_054221899.1  actin-binding LIM protein 1 isoform X40

    3. XM_054365913.1XP_054221888.1  actin-binding LIM protein 1 isoform X34

    4. XM_054365907.1XP_054221882.1  actin-binding LIM protein 1 isoform X31

    5. XM_054365933.1XP_054221908.1  actin-binding LIM protein 1 isoform X45

    6. XM_054365928.1XP_054221903.1  actin-binding LIM protein 1 isoform X42

    7. XM_054365927.1XP_054221902.1  actin-binding LIM protein 1 isoform X41

    8. XM_054365929.1XP_054221904.1  actin-binding LIM protein 1 isoform X43

    9. XM_054365919.1XP_054221894.1  actin-binding LIM protein 1 isoform X36

    10. XM_054365918.1XP_054221893.1  actin-binding LIM protein 1 isoform X35

    11. XM_054365908.1XP_054221883.1  actin-binding LIM protein 1 isoform X7

    12. XM_054365930.1XP_054221905.1  actin-binding LIM protein 1 isoform X44

    13. XM_054365922.1XP_054221897.1  actin-binding LIM protein 1 isoform X38

    14. XM_054365921.1XP_054221896.1  actin-binding LIM protein 1 isoform X37

    15. XM_054365911.1XP_054221886.1  actin-binding LIM protein 1 isoform X33

    16. XM_054365910.1XP_054221885.1  actin-binding LIM protein 1 isoform X32

    17. XM_054365931.1XP_054221906.1  actin-binding LIM protein 1 isoform X22

    18. XM_054365926.1XP_054221901.1  actin-binding LIM protein 1 isoform X17

    19. XM_054365917.1XP_054221892.1  actin-binding LIM protein 1 isoform X9

    20. XM_054365934.1XP_054221909.1  actin-binding LIM protein 1 isoform X25

    21. XM_054365920.1XP_054221895.1  actin-binding LIM protein 1 isoform X12

    22. XM_054365912.1XP_054221887.1  actin-binding LIM protein 1 isoform X5

    23. XM_054365914.1XP_054221889.1  actin-binding LIM protein 1 isoform X6

    24. XM_054365935.1XP_054221910.1  actin-binding LIM protein 1 isoform X26

    25. XM_054365925.1XP_054221900.1  actin-binding LIM protein 1 isoform X16

    26. XM_054365932.1XP_054221907.1  actin-binding LIM protein 1 isoform X23

    27. XM_054365916.1XP_054221891.1  actin-binding LIM protein 1 isoform X8

    28. XM_054365936.1XP_054221911.1  actin-binding LIM protein 1 isoform X2

    29. XM_054365915.1XP_054221890.1  actin-binding LIM protein 1 isoform X7

    30. XM_054365909.1XP_054221884.1  actin-binding LIM protein 1 isoform X2

    31. XM_054365937.1XP_054221912.1  actin-binding LIM protein 1 isoform X27

    32. XM_054365939.1XP_054221914.1  actin-binding LIM protein 1 isoform X47

    33. XM_054365938.1XP_054221913.1  actin-binding LIM protein 1 isoform X46

    34. XM_054365940.1XP_054221915.1  actin-binding LIM protein 1 isoform X30

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003408.1: Suppressed sequence

      Description
      NM_001003408.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.