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    PPP2R1B protein phosphatase 2 scaffold subunit Abeta [ Homo sapiens (human) ]

    Gene ID: 5519, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PPP2R1Bprovided by HGNC
    Official Full Name
    protein phosphatase 2 scaffold subunit Abetaprovided by HGNC
    Primary source
    HGNC:HGNC:9303
    See related
    Ensembl:ENSG00000137713 MIM:603113; AllianceGenome:HGNC:9303
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR65B; PP2A-Abeta
    Summary
    This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
    Expression
    Ubiquitous expression in testis (RPKM 13.7), fat (RPKM 13.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PPP2R1B in Genome Data Viewer
    Location:
    11q23.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (111688000..111766389, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (111698152..111776539, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111597637..111637113, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111410548-111411227 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:111424938-111426137 Neighboring gene Sharpr-MPRA regulatory region 3081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:111435687-111436190 Neighboring gene layilin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3899 Neighboring gene salt inducible kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111563346-111563859 Neighboring gene RN7SK pseudogene 273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111594031-111594566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111603371-111604187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:111605768-111606404 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:111636139-111637042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3900 Neighboring gene uncharacterized LOC124902756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3901 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:111685391-111686590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:111709725-111710226 Neighboring gene G protein subunit gamma 5 pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. Hemmer S, et al. Cancer Genet Cytogenet, 2002 Apr 1. PMID 11996789
    2. Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs. Peng S, et al. Stem Cell Rev Rep, 2023 Aug. PMID 37243830
    3. Chromosome 11q23.1 is an unstable region in B-cell tumor cell lines. Poretti G, et al. Leuk Res, 2011 Jun. PMID 21420167
    4. PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis. Grinthal A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133745, Free PMC Article
    5. Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. Yeh LS, et al. Int J Gynecol Cancer, 2007 Jul-Aug. PMID 17343570

    See all (120) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs.
      Title: Lnc-PPP2R1B Mediates the Alternative Splicing of PPP2R1B by Interacting and Stabilizing HNRNPLL and Promotes Osteogenesis of MSCs.
    2. PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
      Title: PPP2R1B is modulated by ubiquitination and is essential for spermatogenesis.
    3. Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B.
      Title: Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B.
    4. MicroRNA-587 antagonizes 5-fluorouracil-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer.
      Title: MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer.
    5. For PPP2R1B, no mutations were detected in our samples.
      Title: Infrequent mutations of the PPP2R1A and PPP2R1B genes in patients with ovarian cancer.
    6. Data show that the only gene that was expressed, although not at high levels, in all the cells carrying the 11q23.1 amplification was PPP2R1B.
      Title: Chromosome 11q23.1 is an unstable region in B-cell tumor cell lines.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Data show that PR65-dominated fluctuations of PP2A have the effect of opening and closing the enzyme's substrate binding/catalysis interface, as well as altering the positions of certain catalytic residues.
      Title: PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis.
    9. Data show that upon hypoxia, the TGF-beta-induced phosphorylation of Smad3 was inhibited, although Smad2 remained phosphorylated, and Smad3 was dephosphorylated by PP2A.
      Title: Hypoxia-activated Smad3-specific dephosphorylation by PP2A.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Lung cancer
    MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serine/threonine protein phosphatase 2A (65 kDa regulatory subunit A) in T-cell lines PubMed
    Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
    tat HIV-1 Tat associates with the promoters of both PPP2R1B and PPP2R5E to increase PPP2R1B and PPP2R5E RNA and protein levels as well as PP2A activity in Jurkat T cells PubMed
    tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
    Vpr vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
    vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
    vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
    nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26454

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    Names
    protein phosphatase 2, regulatory subunit A, beta
    protein phosphatase 2, structural/regulatory subunit A, beta
    NP_001171033.1
    NP_001171034.1
    NP_002707.3
    NP_859050.1
    NP_859051.1
    XP_016873449.1
    XP_024304368.1
    XP_047283145.1
    XP_047283146.1
    XP_047283147.1
    XP_047283148.1
    XP_047283149.1
    XP_047283150.1
    XP_047283151.1
    XP_047283152.1
    XP_054225214.1
    XP_054225215.1
    XP_054225216.1
    XP_054225217.1
    XP_054225218.1
    XP_054225219.1
    XP_054225220.1
    XP_054225221.1
    XP_054225222.1
    XP_054225223.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012117.3 RefSeqGene

      Range
      5000..33512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177562.2 → NP_001171033.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the coding region compared to variant 1. The resulting isoform (d) is shorter than isoform a.
      Source sequence(s)
      AF163473, AK294716, AP000925, AP001781, DC402587
      Consensus CDS
      CCDS53708.1
      UniProtKB/Swiss-Prot
      P30154
      Related
      ENSP00000343317.6, ENST00000341980.10
      Conserved Domains (3) summary
      pfam13646
      Location:217 → 315
      HEAT_2; HEAT repeats
      sd00044
      Location:257 → 281
      HEAT; HEAT repeat [structural motif]
      cl21454
      Location:363 → 421
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001177563.2 → NP_001171034.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the 5' coding region compared to variant 1. The resulting isoform (e) is shorter than isoform a.
      Source sequence(s)
      AF163473, AK296455, AP000925, DC402587
      Consensus CDS
      CCDS53707.1
      UniProtKB/Swiss-Prot
      P30154
      Related
      ENSP00000376775.2, ENST00000393055.6
      Conserved Domains (4) summary
      COG1413
      Location:115 → 347
      HEAT; HEAT repeat [General function prediction only]
      pfam13646
      Location:374 → 469
      HEAT_2; HEAT repeats
      sd00044
      Location:130 → 154
      HEAT; HEAT repeat [structural motif]
      cl21454
      Location:281 → 339
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_002716.5 → NP_002707.3  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform a

      See identical proteins and their annotated locations for NP_002707.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AF163473, AP000925, BC027596
      Consensus CDS
      CCDS8349.1
      UniProtKB/Swiss-Prot
      A8MY67, B0YJ69, B4DGQ6, B4DK91, B4DWW5, F8W8G1, O75620, P30154, Q8NHV8
      UniProtKB/TrEMBL
      A8K8B0
      Related
      ENSP00000437193.1, ENST00000527614.6
      Conserved Domains (3) summary
      pfam13646
      Location:217 → 315
      HEAT_2; HEAT repeats
      sd00044
      Location:257 → 281
      HEAT; HEAT repeat [structural motif]
      cl21454
      Location:408 → 466
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. NM_181699.3 → NP_859050.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform b

      See identical proteins and their annotated locations for NP_859050.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AF087438, AP001781, BC027596, DB527885
      Consensus CDS
      CCDS8348.1
      UniProtKB/TrEMBL
      A8K8B0
      Related
      ENSP00000311344.5, ENST00000311129.9
      Conserved Domains (4) summary
      pfam13513
      Location:191 → 240
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:217 → 316
      HEAT_2; HEAT repeats
      sd00044
      Location:257 → 281
      HEAT; HEAT repeat [structural motif]
      cl21454
      Location:408 → 466
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. NM_181700.2 → NP_859051.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform c

      See identical proteins and their annotated locations for NP_859051.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region and differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (c) contains a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AK301705, DB527885, DC402587
      Consensus CDS
      CCDS53706.1
      UniProtKB/TrEMBL
      A8K8B0
      Related
      ENSP00000410671.2, ENST00000426998.6
      Conserved Domains (5) summary
      pfam02985
      Location:231 → 261
      HEAT; HEAT repeat
      pfam13513
      Location:127 → 176
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:153 → 252
      HEAT_2; HEAT repeats
      sd00044
      Location:193 → 217
      HEAT; HEAT repeat [structural motif]
      cl21454
      Location:344 → 402
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      111688000..111766389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448600.2 → XP_024304368.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4

      Conserved Domains (2) summary
      COG1413
      Location:177 → 392
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:257 → 281
      HEAT; HEAT repeat [structural motif]

    2. XM_047427193.1 → XP_047283149.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    3. XM_047427194.1 → XP_047283150.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    4. XM_047427195.1 → XP_047283151.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    5. XM_047427191.1 → XP_047283147.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    6. XM_047427190.1 → XP_047283146.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    7. XM_047427192.1 → XP_047283148.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    8. XM_047427189.1 → XP_047283145.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    9. XM_017017960.2 → XP_016873449.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3

    10. XM_047427196.1 → XP_047283152.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      111698152..111776539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369247.1 → XP_054225222.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4

    2. XM_054369243.1 → XP_054225218.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    3. XM_054369244.1 → XP_054225219.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    4. XM_054369245.1 → XP_054225220.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2

    5. XM_054369241.1 → XP_054225216.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    6. XM_054369240.1 → XP_054225215.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    7. XM_054369242.1 → XP_054225217.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    8. XM_054369239.1 → XP_054225214.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1

    9. XM_054369246.1 → XP_054225221.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3

    10. XM_054369248.1 → XP_054225223.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30154.3 GenPept UniProtKB/Swiss-Prot:P30154

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