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    CT45A8 cancer/testis antigen family 45 member A8 [ Homo sapiens (human) ]

    Gene ID: 102723737, updated on 10-Oct-2023

    Summary

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    Official Symbol
    CT45A8provided by HGNC
    Official Full Name
    cancer/testis antigen family 45 member A8provided by HGNC
    Primary source
    HGNC:HGNC:51261
    See related
    Ensembl:ENSG00000278085 AllianceGenome:HGNC:51261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT45-2; CT45A2; CT45A9
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 8.0) See more
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    Genomic context

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    Location:
    Xq26.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135846497..135854592, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134154884..134162973, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134928695..134936735, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A2 Neighboring gene cancer/testis antigen family 45 member A7 Neighboring gene cancer/testis antigen family 45 member A9 Neighboring gene cancer/testis antigen family 45 member A10 Neighboring gene Sharpr-MPRA regulatory region 13624

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen YT, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905330, Free PMC Article
    2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
    3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    cancer/testis antigen family 45 member A8
    Names
    Cancer/testis antigen 45-2
    Cancer/testis antigen 45A2
    Cancer/testis antigen 45A9
    Cancer/testis antigen family 45 member A2
    Cancer/testis antigen family 45 member A9
    cancer/testis antigen 45A8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291535.1 → NP_001278464.1  cancer/testis antigen family 45 member A8

      See identical proteins and their annotated locations for NP_001278464.1

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76033.1
      UniProtKB/Swiss-Prot
      P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
      Related
      ENSP00000481184.1, ENST00000611660.5
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135846497..135854592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531241.3 → XP_011529543.1  cancer/testis antigen family 45 member A8 isoform X1

      See identical proteins and their annotated locations for XP_011529543.1

      UniProtKB/Swiss-Prot
      P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
      Related
      ENSP00000480644.1, ENST00000611438.1
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. XM_006724799.2 → XP_006724862.1  cancer/testis antigen family 45 member A8 isoform X1

      See identical proteins and their annotated locations for XP_006724862.1

      UniProtKB/Swiss-Prot
      P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134154884..134162973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326361.1 → XP_054182336.1  cancer/testis antigen family 45 member A8 isoform X1

    2. XM_054326362.1 → XP_054182337.1  cancer/testis antigen family 45 member A8 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DMV1.1 GenPept UniProtKB/Swiss-Prot:P0DMV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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