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    NRK Nik related kinase [ Homo sapiens (human) ]

    Gene ID: 203447, updated on 28-Oct-2024

    Summary

    Official Symbol
    NRKprovided by HGNC
    Official Full Name
    Nik related kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:25391
    See related
    Ensembl:ENSG00000123572 MIM:300791; AllianceGenome:HGNC:25391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NESK
    Summary
    The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010]
    Expression
    Biased expression in ovary (RPKM 15.5), placenta (RPKM 15.0) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NRK in Genome Data Viewer
    Location:
    Xq22.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (105821786..105958610)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (104253759..104390422)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (105066532..105202602)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein like 2 Neighboring gene uncharacterized LOC107985680 Neighboring gene NANOG hESC enhancer GRCh37_chrX:104880562-104881086 Neighboring gene NANOG hESC enhancer GRCh37_chrX:104892408-104892914 Neighboring gene uncharacterized LOC105373303 Neighboring gene RNA, U6 small nuclear 207, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:105065433-105066413 Neighboring gene uncharacterized LOC105373304 Neighboring gene HNF1 motif-containing MPRA enhancer 3 Neighboring gene uncharacterized LOC105373305 Neighboring gene serpin family A member 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16788, MGC131849, DKFZp686A17109

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    nik-related protein kinase
    NP_940867.2
    XP_006724695.1
    XP_006724696.1
    XP_006724697.1
    XP_011529189.1
    XP_054182632.1
    XP_054182633.1
    XP_054182634.1
    XP_054182635.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021425.2 RefSeqGene

      Range
      4997..141068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_198465.4NP_940867.2  nik-related protein kinase

      See identical proteins and their annotated locations for NP_940867.2

      Status: REVIEWED

      Source sequence(s)
      BX538345, KF459287, Z68339, Z69734, Z70274, Z83850
      Consensus CDS
      CCDS65305.1
      UniProtKB/Swiss-Prot
      Q32ND6, Q5H9K2, Q6ZMP2, Q7Z2Y5
      Related
      ENSP00000434830.1, ENST00000243300.14
      Conserved Domains (3) summary
      smart00220
      Location:25313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:12131549
      CNH; CNH domain
      cl21453
      Location:18313
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      105821786..105958610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530887.4XP_011529189.1  nik-related protein kinase isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:29258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:11581494
      CNH; CNH domain
      cl21453
      Location:29258
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006724632.4XP_006724695.1  nik-related protein kinase isoform X1

      Conserved Domains (3) summary
      smart00220
      Location:25313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:12131541
      CNH; CNH domain
      cl21453
      Location:18313
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006724633.4XP_006724696.1  nik-related protein kinase isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:25313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:12131501
      CNH; CNH domain
      cl21453
      Location:18313
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006724634.5XP_006724697.1  nik-related protein kinase isoform X4

      Conserved Domains (3) summary
      smart00220
      Location:25313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl02434
      Location:12131493
      CNH; CNH domain
      cl21453
      Location:18313
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      104253759..104390422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326660.1XP_054182635.1  nik-related protein kinase isoform X3

    2. XM_054326657.1XP_054182632.1  nik-related protein kinase isoform X1

    3. XM_054326658.1XP_054182633.1  nik-related protein kinase isoform X2

    4. XM_054326659.1XP_054182634.1  nik-related protein kinase isoform X4