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    Cpne2 copine II [ Mus musculus (house mouse) ]

    Gene ID: 234577, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cpne2provided by MGI
    Official Full Name
    copine IIprovided by MGI
    Primary source
    MGI:MGI:2387578
    See related
    Ensembl:ENSMUSG00000034361 AllianceGenome:MGI:2387578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3322401K10Rik
    Summary
    Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in colon adult (RPKM 18.5), subcutaneous fat pad adult (RPKM 17.3) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cpne2 in Genome Data Viewer
    Location:
    8 C5; 8 46.55 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95259299..95297157)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94532674..94570529)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330175E14 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:96958082-96958382 Neighboring gene STARR-seq mESC enhancer starr_22354 Neighboring gene STARR-seq mESC enhancer starr_22355 Neighboring gene NLR family, CARD domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_22357 Neighboring gene predicted gene, 51584 Neighboring gene microRNA 7072 Neighboring gene STARR-seq mESC enhancer starr_22358 Neighboring gene predicted gene, 38555 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_22359 Neighboring gene STARR-positive B cell enhancer mm9_chr8:97125541-97125842 Neighboring gene predicted gene, 57522 Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association. Perestenko P, et al. FEBS J, 2015 Oct. PMID 26175110
    2. Copines-1, -2, -3, -6 and -7 show different calcium-dependent intracellular membrane translocation and targeting. Perestenko PV, et al. FEBS J, 2010 Dec. PMID 21087455
    3. The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans. Creutz CE, et al. J Biol Chem, 1998 Jan 16. PMID 9430674
    4. The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Titz B, et al. Oncogene, 2010 Nov 4. PMID 20697350, Free PMC Article
    5. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The second C2-domain of copine-2 is responsible for calcium-dependent membrane association.
      Title: The second C2-domain of copine-2, copine-6 and copine-7 is responsible for their calcium-dependent membrane association.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30751, MGC37787

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in clathrin-coated endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    copine-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153507.2 → NP_705727.1  copine-2

      See identical proteins and their annotated locations for NP_705727.1

      Status: REVIEWED

      Source sequence(s)
      BC031801
      Consensus CDS
      CCDS22543.1
      UniProtKB/Swiss-Prot
      P59108, Q8K1D7
      UniProtKB/TrEMBL
      A0A0R4J1D0
      Related
      ENSMUSP00000045755.3, ENSMUST00000048653.10
      Conserved Domains (3) summary
      cd04047
      Location:155 → 267
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:24 → 141
      C2A_Copine; C2 domain first repeat in Copine
      cl00057
      Location:279 → 530
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95259299..95297157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312732.3 → XP_017168221.1  copine-2 isoform X1

      Conserved Domains (3) summary
      cd04047
      Location:155 → 267
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:24 → 141
      C2A_Copine; C2 domain first repeat in Copine
      cl00057
      Location:279 → 353
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59108.1 GenPept UniProtKB/Swiss-Prot:P59108

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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