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    Tnfrsf19 tumor necrosis factor receptor superfamily, member 19 [ Mus musculus (house mouse) ]

    Gene ID: 29820, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tnfrsf19provided by MGI
    Official Full Name
    tumor necrosis factor receptor superfamily, member 19provided by MGI
    Primary source
    MGI:MGI:1352474
    See related
    Ensembl:ENSMUSG00000060548 AllianceGenome:MGI:1352474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAJ; Troy; TRADE; TAJ-ALPHA
    Summary
    Predicted to enable signaling receptor activity. Acts upstream of or within hair follicle development and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; integumental system; and respiratory system. Orthologous to human TNFRSF19 (TNF receptor superfamily member 19). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in adrenal adult (RPKM 14.8), CNS E11.5 (RPKM 12.6) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfrsf19 in Genome Data Viewer
    Location:
    14 D1; 14 32.06 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (61201283..61284304, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (60963834..61046855, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr14:61418588-61418889 Neighboring gene C1q and tumor necrosis factor related protein 9 Neighboring gene mitochondrial intermediate peptidase, opposite strand Neighboring gene mitochondrial intermediate peptidase Neighboring gene STARR-seq mESC enhancer starr_36865 Neighboring gene STARR-seq mESC enhancer starr_36867 Neighboring gene STARR-seq mESC enhancer starr_36869 Neighboring gene STARR-seq mESC enhancer starr_36870 Neighboring gene VISTA enhancer mm7 Neighboring gene STARR-seq mESC enhancer starr_36873 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61665054-61665237 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:61675420-61675649 Neighboring gene predicted gene, 41167 Neighboring gene predicted gene, 41168 Neighboring gene STARR-positive B cell enhancer ABC_E8562 Neighboring gene sacsin Neighboring gene sarcoglycan, gamma (dystrophin-associated glycoprotein)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Propentofylline targets TROY, a novel microglial signaling pathway. Jacobs VL, et al. PLoS One, 2012. PMID 22649568, Free PMC Article
    2. Characterization of TROY/TNFRSF19/TAJ-expressing cells in the adult mouse forebrain. Hisaoka T, et al. Brain Res, 2006 Sep 19. PMID 16870160
    3. Inhibition of TROY promotes OPC differentiation and increases therapeutic efficacy of OPC graft for spinal cord injury. Sun L, et al. Stem Cells Dev, 2014 Sep 1. PMID 24749558, Free PMC Article
    4. Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway. Dhruv HD, et al. J Neurooncol, 2016 Feb. PMID 26559543, Free PMC Article
    5. Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Hu S, et al. Genomics, 1999 Nov 15. PMID 10585776

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
      Title: Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification.
    2. data show that Troy marks a renal stem/progenitor cell population in the developing kidney that in adult kidney contributes to homeostasis, predominantly of the collecting duct, and regeneration.
      Title: Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.
    3. High TROY expression is associated with glioblastoma cell invasion.
      Title: Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway.
    4. TROY negatively modulates remyelination in the central nervous system.
      Title: Inhibition of TROY promotes OPC differentiation and increases therapeutic efficacy of OPC graft for spinal cord injury.
    5. the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation.
      Title: TROY interacts with Rho guanine nucleotide dissociation inhibitor α (RhoGDIα) to mediate Nogo-induced inhibition of neurite outgrowth.
    6. TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells.
      Title: Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells.
    7. TROY is expressed in microglia, involved in their migration and targeted by propentofylline.
      Title: Propentofylline targets TROY, a novel microglial signaling pathway.
    8. functional overlap of Troy and Eda signalling pathways is mediated by NF-kappaB independent pathways
      Title: Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.
    9. TROY was expressed in some specific subsets of glial cells in the olfactory bulb, including OECs, and may play some roles in the developing and adult olfactory system
      Title: TROY, a novel member of the tumor necrosis factor receptor superfamily in the central nervous system.
    10. Troy protein is expressed in the matrix region of developing hair follicles and may have a subtle function in skin appendage development.
      Title: Troy binding to lymphotoxin-alpha activates NF kappa B mediated transcription.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hair follicle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 19
    Names
    Toxicity and JNK inducer

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164155.1 → NP_001157627.1  tumor necrosis factor receptor superfamily member 19 precursor

      See identical proteins and their annotated locations for NP_001157627.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK083283, BB526959, BB858206, BY637570, CB244999
      Consensus CDS
      CCDS36941.1
      UniProtKB/Swiss-Prot
      Q80T13, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9JLL3, Q9QXW7
      UniProtKB/TrEMBL
      Q8BUM7
      Related
      ENSMUSP00000106867.3, ENSMUST00000111236.4
      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    2. NM_013869.5 → NP_038897.4  tumor necrosis factor receptor superfamily member 19 precursor

      See identical proteins and their annotated locations for NP_038897.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK028146, AK083283, BY637570, CF727607
      Consensus CDS
      CCDS36941.1
      UniProtKB/Swiss-Prot
      Q80T13, Q812G3, Q9JHF1, Q9JJH6, Q9JLL2, Q9JLL3, Q9QXW7
      UniProtKB/TrEMBL
      Q8BUM7
      Related
      ENSMUSP00000106865.3, ENSMUST00000111234.10
      Conserved Domains (1) summary
      cd13418
      Location:33 → 149
      TNFRSF19; Tumor necrosis factor receptor superfamily member 19 (TNFRSF19), also known as TROY

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      61201283..61284304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158664.1 → XP_036014557.1  tumor necrosis factor receptor superfamily member 19 isoform X1

      UniProtKB/TrEMBL
      Q8BWR1
      Conserved Domains (1) summary
      cl22855
      Location:1 → 17
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLL3.2 GenPept UniProtKB/Swiss-Prot:Q9JLL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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