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    Camk2g calcium/calmodulin-dependent protein kinase II gamma [ Mus musculus (house mouse) ]

    Gene ID: 12325, updated on 28-Oct-2024

    Summary

    Official Symbol
    Camk2gprovided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase II gammaprovided by MGI
    Primary source
    MGI:MGI:88259
    See related
    Ensembl:ENSMUSG00000021820 AllianceGenome:MGI:88259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Camkg
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity. Involved in regulation of neuron projection development and regulation of relaxation of cardiac muscle. Acts upstream of or within G1/S transition of mitotic cell cycle; calcium ion transport; and protein autophosphorylation. Located in postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human CAMK2G (calcium/calmodulin dependent protein kinase II gamma). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in cortex adult (RPKM 49.3), cerebellum adult (RPKM 39.7) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Camk2g in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20784943..20844225, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20734873..20794157, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Neighboring gene STARR-seq mESC enhancer starr_36118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21604587-21604774 Neighboring gene predicted gene, 30108 Neighboring gene STARR-seq mESC enhancer starr_36120 Neighboring gene plasminogen activator, urokinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • 5930429P18Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of relaxation of cardiac muscle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of calcium- and calmodulin-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit gamma
    Names
    Ca2+/calmodulin-dependent protein kinase II
    CaMK II
    caMK-II subunit gamma
    NP_001034227.1
    NP_001034228.1
    NP_001347115.1
    NP_001411380.1
    NP_001411381.1
    NP_001411382.1
    NP_001411383.1
    NP_001411384.1
    NP_001411385.1
    NP_001411386.1
    NP_001411387.1
    NP_001411388.1
    NP_001411389.1
    NP_001411390.1
    NP_848712.2
    XP_006518556.1
    XP_006518563.1
    XP_030103477.1
    XP_030103478.1
    XP_030103479.1
    XP_030103480.1
    XP_030103481.1
    XP_030103483.1
    XP_030103484.1
    XP_030103485.1
    XP_030103486.1
    XP_030103487.1
    XP_030103488.1
    XP_030103489.1
    XP_036014315.1
    XP_036014316.1
    XP_036014317.1
    XP_036014318.1
    XP_036014319.1
    XP_036014320.1
    XP_036014321.1
    XP_036014322.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039138.3NP_001034227.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_001034227.1

      Status: VALIDATED

      Source sequence(s)
      AC121599
      Consensus CDS
      CCDS26855.1
      UniProtKB/TrEMBL
      A0A2I3BQP6
      Related
      ENSMUSP00000079298.7, ENSMUST00000080440.14
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:386513
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    2. NM_001039139.3NP_001034228.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3

      See identical proteins and their annotated locations for NP_001034228.1

      Status: VALIDATED

      Source sequence(s)
      AC121599
      Consensus CDS
      CCDS26856.1
      UniProtKB/TrEMBL
      A0A2I3BQP6, Q6ZWS7
      Related
      ENSMUSP00000098398.4, ENSMUST00000100837.11
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:363490
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    3. NM_001360186.2NP_001347115.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121599
      UniProtKB/TrEMBL
      A0A2I3BQP6
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:395522
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    4. NM_001424451.1NP_001411380.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121599
    5. NM_001424452.1NP_001411381.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121599
    6. NM_001424453.1NP_001411382.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC121599
    7. NM_001424454.1NP_001411383.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC121599
    8. NM_001424455.1NP_001411384.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC121599
    9. NM_001424456.1NP_001411385.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC121599
    10. NM_001424457.1NP_001411386.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC121599
    11. NM_001424458.1NP_001411387.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC121599
    12. NM_001424459.1NP_001411388.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC121599
      Related
      ENSMUSP00000154158.2, ENSMUST00000226630.2
    13. NM_001424460.1NP_001411389.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC121599
    14. NM_001424461.1NP_001411390.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC121599
    15. NM_178597.6NP_848712.2  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_848712.2

      Status: VALIDATED

      Source sequence(s)
      AC121599
      Consensus CDS
      CCDS26857.1
      UniProtKB/Swiss-Prot
      Q3U3H3, Q8VED3, Q923T9
      UniProtKB/TrEMBL
      A0A2I3BQP6
      Related
      ENSMUSP00000071720.7, ENSMUST00000071816.7
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:397524
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RNA

    1. NR_188718.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121599
    2. NR_188719.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121599
    3. NR_188720.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121599
    4. NR_188721.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121599
    5. NR_188722.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121599

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20784943..20844225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247621.1XP_030103481.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X22

      Conserved Domains (2) summary
      pfam08332
      Location:292419
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006518493.4XP_006518556.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6

      See identical proteins and their annotated locations for XP_006518556.1

      UniProtKB/TrEMBL
      A0A2I3BQP6
      Conserved Domains (2) summary
      cd14086
      Location:12303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:422549
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
    3. XM_030247620.2XP_030103480.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X21

      Conserved Domains (2) summary
      pfam08332
      Location:319446
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    4. XM_030247619.2XP_030103479.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X19

      UniProtKB/TrEMBL
      A0A2I3BQP6
      Conserved Domains (2) summary
      pfam08332
      Location:342469
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    5. XM_036158425.1XP_036014318.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X20

      Conserved Domains (2) summary
      pfam08332
      Location:330457
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    6. XM_030247617.2XP_030103477.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X17

      UniProtKB/TrEMBL
      A0A2I3BQP6
      Conserved Domains (2) summary
      pfam08332
      Location:353480
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    7. XM_030247618.2XP_030103478.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X18

      Conserved Domains (2) summary
      pfam08332
      Location:351478
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    8. XM_006518500.5XP_006518563.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X16

      UniProtKB/TrEMBL
      A0A2I3BQP6
      Conserved Domains (2) summary
      pfam08332
      Location:374501
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:11221
      PKc_like; Protein Kinases, catalytic domain
    9. XM_030247623.2XP_030103483.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

      Conserved Domains (2) summary
      pfam08332
      Location:234361
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain
    10. XM_030247625.2XP_030103485.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X26

      Conserved Domains (2) summary
      pfam08332
      Location:213340
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain
    11. XM_030247626.2XP_030103486.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X27

      Conserved Domains (2) summary
      pfam08332
      Location:211338
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain
    12. XM_030247624.2XP_030103484.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

      Conserved Domains (2) summary
      pfam08332
      Location:234361
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain
    13. XM_030247628.2XP_030103488.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X29

      Conserved Domains (2) summary
      pfam08332
      Location:202329
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain
    14. XM_030247629.2XP_030103489.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X30

      Conserved Domains (2) summary
      pfam08332
      Location:179306
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain
    15. XM_036158426.1XP_036014319.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

      Conserved Domains (2) summary
      pfam08332
      Location:234361
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain
    16. XM_036158422.1XP_036014315.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X7

      UniProtKB/TrEMBL
      A0A2I3BQP6
      Conserved Domains (2) summary
      pfam08332
      Location:419546
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:56266
      PKc_like; Protein Kinases, catalytic domain
    17. XM_036158429.1XP_036014322.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X31

      Conserved Domains (2) summary
      pfam08332
      Location:173300
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:152
      PKc_like; Protein Kinases, catalytic domain
    18. XM_036158423.1XP_036014316.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X12

      Conserved Domains (2) summary
      pfam08332
      Location:396523
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:56266
      PKc_like; Protein Kinases, catalytic domain
    19. XM_036158424.1XP_036014317.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X13

      UniProtKB/TrEMBL
      A0A2I3BQP6
      Conserved Domains (2) summary
      pfam08332
      Location:387514
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:56266
      PKc_like; Protein Kinases, catalytic domain
    20. XM_036158428.1XP_036014321.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X25

      UniProtKB/TrEMBL
      A0A286YCW8
      Conserved Domains (2) summary
      pfam08332
      Location:144271
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:152
      PKc_like; Protein Kinases, catalytic domain
    21. XM_030247627.2XP_030103487.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X28

      Conserved Domains (2) summary
      pfam08332
      Location:205332
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:152
      PKc_like; Protein Kinases, catalytic domain
    22. XM_036158427.1XP_036014320.1  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X24

      Conserved Domains (2) summary
      pfam08332
      Location:234361
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1181
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003950821.2 RNA Sequence

    2. XR_004938372.1 RNA Sequence

    3. XR_003950818.2 RNA Sequence

    4. XR_874287.4 RNA Sequence