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    Acsl1 acyl-CoA synthetase long-chain family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25288, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Acsl1provided by RGD
    Official Full Name
    acyl-CoA synthetase long-chain family member 1provided by RGD
    Primary source
    RGD:2015
    See related
    EnsemblRapid:ENSRNOG00000010633 AllianceGenome:RGD:2015
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ACS; Acas; COAA; Facl2
    Summary
    Enables arachidonate-CoA ligase activity; oleoyl-CoA ligase activity; and phytanate-CoA ligase activity. Involved in several processes, including fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; and positive regulation of long-chain fatty acid import across plasma membrane. Located in mitochondrial outer membrane and peroxisomal membrane. Biomarker of obesity. Orthologous to human ACSL1 (acyl-CoA synthetase long chain family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 2227.9), Heart (RPKM 1039.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acsl1 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52487870..52554110, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45755246..45821541, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48937456..49003898, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene caspase 3 Neighboring gene primase and DNA directed polymerase Neighboring gene centromere protein U Neighboring gene uncharacterized LOC108348397 Neighboring gene uncharacterized LOC120097416 Neighboring gene small nucleolar RNA SNORA26

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Long-chain acyl-CoenzymeA synthetase-2 mRNA: increased cerebral cortex expression in an animal model of depression. Setnik B, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2004 May. PMID 15093965
    2. Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning. Wang YL, et al. Obes Res, 2004 Nov. PMID 15601973
    3. Inhibitory effect of D-penicillamine on the fibrosis caused by bleomycin treatment in rat carrageein granuloma. Otsuka K, et al. Chem Pharm Bull (Tokyo), 1977 Jun. PMID 70279
    4. Effect of starvation on hepatic acyl-CoA synthetase, carnitine palmitoyltransferase-I, and acetyl-CoA carboxylase mRNA levels in rats. Ryu MH, et al. Nutrition, 2005 Apr. PMID 15811777
    5. Marked enhancement of acyl-CoA synthetase activity and mRNA, paralleled to lipoprotein lipase mRNA, in adipose tissues of Zucker obese rats (fa/fa). Shimomura I, et al. Biochim Biophys Acta, 1992 Mar 4. PMID 1543733

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-34c promotes hepatic stellate cell activation and Liver Fibrogenesis by suppressing ACSL1 expression.
      Title: MiR-34c promotes hepatic stellate cell activation and Liver Fibrogenesis by suppressing ACSL1 expression.
    2. here we revealed that ACSs (Faa1 and Faa4 in yeast and ACSL1, ACSL4, ACSL5, ACSL6, and ACSVL4 in mammals) are involved in LCB uptake. In addition, we provided important insight into the molecular mechanism of LCFA transport
      Title: Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases.
    3. Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function
      Title: Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function.
    4. Acsl isozymes play distinct roles in the control of AA remodeling in rat fibroblasts: Acsl4 acts as the first step of enzyme for AA remodeling following IL-1beta stimulation, and Acsl1 is involved in the maintenance of some AA-containing PC species.
      Title: Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1β-stimulated rat fibroblasts.
    5. rat long chain acyl-coa synthetase 1 has a role in fatty acid metabolism in rat primary hepatocytes
      Title: Overexpression of rat long chain acyl-coa synthetase 1 alters fatty acid metabolism in rat primary hepatocytes.
    6. The fatty metabolism is stimulated in the CNS during a chronic pain state.
      Title: Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation.
    7. Long-chain acyl-CoenzymeA synthetase-2 expression is significantly upregulated in distinct regions of the frontal cortex in learned helpless rats relative to controls
      Title: Long-chain acyl-CoenzymeA synthetase-2 mRNA: increased cerebral cortex expression in an animal model of depression.
    8. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
      Title: Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oleoyl-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phytanate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pristanate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-chain fatty acid import into cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of long-chain fatty acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to nutrient IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to oleic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in very long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase 1
    Names
    Acyl CoA synthetase, long chain
    LACS 1
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 2
    long-chain acyl-CoA synthetase 1
    long-chain-fatty-acid--CoA ligase, liver isozyme
    phytanate--CoA ligase
    NP_036952.1
    XP_006253184.1
    XP_006253185.1
    XP_006253186.1
    XP_006253187.1
    XP_006253188.1
    XP_006253189.1
    XP_038950128.1
    XP_063131127.1
    XP_063131128.1
    XP_063131129.1
    XP_063131130.1
    XP_063131132.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012820.2 → NP_036952.1  long-chain-fatty-acid--CoA ligase 1

      See identical proteins and their annotated locations for NP_036952.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      P18163
      UniProtKB/TrEMBL
      A6JPN3, A6JPN4
      Related
      ENSRNOP00000014235.1, ENSRNOT00000014235.5
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      52487870..52554110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094200.2 → XP_038950128.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

      UniProtKB/TrEMBL
      A6JPN4
      Related
      ENSRNOP00000108734.1, ENSRNOT00000164041.1
      Conserved Domains (1) summary
      cd05927
      Location:117 → 661
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    2. XM_006253123.3 → XP_006253185.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253185.1

      UniProtKB/Swiss-Prot
      P18163
      UniProtKB/TrEMBL
      A6JPN3, A6JPN4
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    3. XM_063275058.1 → XP_063131128.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    4. XM_006253122.3 → XP_006253184.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253184.1

      UniProtKB/Swiss-Prot
      P18163
      UniProtKB/TrEMBL
      A6JPN3, A6JPN4
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    5. XM_006253125.5 → XP_006253187.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253187.1

      UniProtKB/Swiss-Prot
      P18163
      UniProtKB/TrEMBL
      A6JPN3, A6JPN4
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    6. XM_063275060.1 → XP_063131130.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    7. XM_063275062.1 → XP_063131132.1  long-chain-fatty-acid--CoA ligase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8L2R6L8
      Related
      ENSRNOP00000072677.2, ENSRNOT00000089501.3

    8. XM_006253126.4 → XP_006253188.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253188.1

      UniProtKB/Swiss-Prot
      P18163
      UniProtKB/TrEMBL
      A6JPN3, A6JPN4
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    9. XM_006253127.1 → XP_006253189.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253189.1

      UniProtKB/Swiss-Prot
      P18163
      UniProtKB/TrEMBL
      A6JPN3, A6JPN4
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    10. XM_006253124.4 → XP_006253186.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      See identical proteins and their annotated locations for XP_006253186.1

      UniProtKB/Swiss-Prot
      P18163
      UniProtKB/TrEMBL
      A6JPN3, A6JPN4
      Conserved Domains (1) summary
      cd05927
      Location:117 → 695
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    11. XM_063275059.1 → XP_063131129.1  long-chain-fatty-acid--CoA ligase 1 isoform X2

    12. XM_063275057.1 → XP_063131127.1  long-chain-fatty-acid--CoA ligase 1 isoform X1

      UniProtKB/Swiss-Prot
      P18163
      UniProtKB/TrEMBL
      A6JPN3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18163.1 GenPept UniProtKB/Swiss-Prot:P18163

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