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    Gab1 GRB2-associated binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361388, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gab1provided by RGD
    Official Full Name
    GRB2-associated binding protein 1provided by RGD
    Primary source
    RGD:1311085
    See related
    EnsemblRapid:ENSRNOG00000017879 AllianceGenome:RGD:1311085
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling adaptor activity. Involved in response to hepatocyte growth factor. Predicted to be located in cell-cell junction. Predicted to be active in cell cortex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 124.9), Kidney (RPKM 123.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gab1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (44035693..44143617)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (27131262..27239236)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (30794290..30903819)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 38 Neighboring gene ribosomal protein L35, pseudogene 11 Neighboring gene uncharacterized LOC120098604 Neighboring gene uncharacterized LOC134483632 Neighboring gene uncharacterized LOC120098602 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 Neighboring gene FRAS1 related extracellular matrix 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. Su D, et al. Biomed Pharmacother, 2017 Sep. PMID 28738535
    2. Treatment with insulin uncovers the motogenic capacity of nitric oxide in aortic smooth muscle cells: dependence on Gab1 and Gab1-SHP2 association. Dixit M, et al. Circ Res, 2003 Nov 14. PMID 14551245
    3. Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules. Hoffmann KM, et al. Cell Signal, 2006 Jul. PMID 16185843
    4. Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Itoh M, et al. Mol Cell Biol, 2000 May. PMID 10779359, Free PMC Article
    5. Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes. Cherif M, et al. Biomed Res Int, 2015. PMID 26090437, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits.
      Title: Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits.
    2. A novel role of GAB1 and its down-stream signaling PI3K/AKT.
      Title: Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis.
    3. using an in vitro model, we demonstrated that overexpressing Gab1 in neonatal cardiomyocytes, under hypoxic condition, resulted in the reduction of apoptosis suggesting a role for this protein in cardiomyocyte survival
      Title: Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes.
    4. While EGF activated Gab1 and Shc equally, within the same concentration range, HGF very potently and almost exclusively activated Gab1, having only a minimal effect on Shc
      Title: The involvement of the docking protein Gab1 in mitogenic signalling induced by EGF and HGF in rat hepatocytes.
    5. Report role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
      Title: A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
    6. role of Grb2-associated binder-1 (Gab1) in signaling pathways downstream of growth factor receptors.
      Title: Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor.
    7. Gab1 activation plays a central role in HGF's ability to stimulate intracellular transduction cascades in pancreatic acinar cells and this action likely plays a key role in HGF's ability to alter pancreatic cell function (i.e., growth/regeneration).
      Title: Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules.
    8. Gab1, considered a physiological activator of protein tyrosine phosphatase SHP2, increases cell motility in the presence but not the absence of insulin.
      Title: Treatment with insulin uncovers the motogenic capacity of nitric oxide in aortic smooth muscle cells: dependence on Gab1 and Gab1-SHP2 association.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within interleukin-6-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within labyrinthine layer development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to hepatocyte growth factor IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GRB2-associated-binding protein 1
    Names
    growth factor receptor bound protein 2-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108444.1 → NP_001101914.1  GRB2-associated-binding protein 1

      See identical proteins and their annotated locations for NP_001101914.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A0A0G2JZD5, A6IYG9, C6JUQ2
      Related
      ENSRNOP00000102564.1, ENSRNOT00000169434.1
      Conserved Domains (2) summary
      cd01266
      Location:3 → 125
      PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain
      pfam00169
      Location:6 → 115
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      44035693..44143617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097824.2 → XP_038953752.1  GRB2-associated-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZD5, C6JUQ2
      Conserved Domains (1) summary
      cl17171
      Location:1 → 22
      PH-like; Pleckstrin homology-like domain

    2. XM_039097821.2 → XP_038953749.1  GRB2-associated-binding protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZD5, C6JUQ2, D3ZAL7
      Related
      ENSRNOP00000024390.4, ENSRNOT00000024390.7
      Conserved Domains (1) summary
      cd01266
      Location:3 → 125
      PH_Gab1_Gab2; Grb2-associated binding proteins 1 and 2 pleckstrin homology (PH) domain

    3. XM_063278117.1 → XP_063134187.1  GRB2-associated-binding protein 1 isoform X3

    4. XM_039097823.2 → XP_038953751.1  GRB2-associated-binding protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZD5, C6JUQ2
      Conserved Domains (1) summary
      cl17171
      Location:1 → 22
      PH-like; Pleckstrin homology-like domain

    5. XM_063278118.1 → XP_063134188.1  GRB2-associated-binding protein 1 isoform X4

      Related
      ENSRNOP00000071006.3, ENSRNOT00000083219.3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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