U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    S100a16 S100 calcium binding protein A16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361991, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    S100a16provided by RGD
    Official Full Name
    S100 calcium binding protein A16provided by RGD
    Primary source
    RGD:1306770
    See related
    EnsemblRapid:ENSRNOG00000012053 AllianceGenome:RGD:1306770
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; calcium-dependent protein binding activity; and protein homodimerization activity. Predicted to act upstream of or within response to calcium ion. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in extracellular space; nucleus; and perinuclear region of cytoplasm. Orthologous to human S100A16 (S100 calcium binding protein A16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 505.4), Heart (RPKM 349.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See S100a16 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178313986..178319696)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (176016405..176022117)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189923140..189928850)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A13 Neighboring gene S100 calcium binding protein A14 Neighboring gene U6 spliceosomal RNA Neighboring gene S100 calcium binding protein A3 Neighboring gene MIER family member 3, pseudogene 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Estrogen suppresses adipogenesis by inhibiting S100A16 expression. Zhang R, et al. J Mol Endocrinol, 2014 Jun. PMID 24501224, Free PMC Article
    2. S100A16 mediation of weight gain attenuation induced by dietary calcium. Zhang R, et al. Metabolism, 2012 Feb. PMID 21871643
    3. S100A16, a novel calcium-binding protein of the EF-hand superfamily. Sturchler E, et al. J Biol Chem, 2006 Dec 15. PMID 17030513
    4. Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Fornander L, et al. Proteomics Clin Appl, 2011 Oct. PMID 21805676
    5. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Estrogen suppressed adipogenesis by inhibiting S100A16 expression.
      Title: Estrogen suppresses adipogenesis by inhibiting S100A16 expression.
    2. High-calcium diets may lead to nuclear exclusion of S100A16, which results in the inhibition of adipogenesis and enhanced insulin sensitivity.
      Title: S100A16 mediation of weight gain attenuation induced by dietary calcium.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    protein S100-A16

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108557.2 → NP_001102027.1  protein S100-A16

      See identical proteins and their annotated locations for NP_001102027.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158598
      UniProtKB/TrEMBL
      A6J6N9, A6J6P2, B0BMX3
      Related
      ENSRNOP00000016499.4, ENSRNOT00000016499.9
      Conserved Domains (1) summary
      cd05022
      Location:6 → 94
      S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      178313986..178319696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102692.2 → XP_038958620.1  protein S100-A16 isoform X1

      UniProtKB/TrEMBL
      A6J6N9, A6J6P2, B0BMX3
      Conserved Domains (1) summary
      cd05022
      Location:6 → 94
      S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

    2. XM_006232718.4 → XP_006232780.1  protein S100-A16 isoform X1

      See identical proteins and their annotated locations for XP_006232780.1

      UniProtKB/TrEMBL
      A6J6N9, A6J6P2, B0BMX3
      Conserved Domains (1) summary
      cd05022
      Location:6 → 94
      S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...

    3. XM_006232717.5 → XP_006232779.1  protein S100-A16 isoform X1

      See identical proteins and their annotated locations for XP_006232779.1

      UniProtKB/TrEMBL
      A6J6N9, A6J6P2, B0BMX3
      Conserved Domains (1) summary
      cd05022
      Location:6 → 94
      S-100A13; S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to which ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools