Tbca tubulin folding cofactor A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbcaprovided by RGD
Official Full Name: tubulin folding cofactor Aprovided by RGD
Primary source: RGD:1311538
See related: EnsemblRapid:ENSRNOG00000048342 AllianceGenome:RGD:1311538
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable tubulin binding activity. Predicted to be involved in protein folding and tubulin complex assembly. Predicted to be located in nucleolus. Predicted to be active in microtubule cytoskeleton. Orthologous to human TBCA (tubulin folding cofactor A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 608.5), Testes (RPKM 578.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (27745985..27800624)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (26011714..26065909)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (24449498..24505351)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in post-chaperonin tubulin folding pathway	IEA Inferred from Electronic Annotation more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in tubulin complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulin-specific chaperone A

Names: CFA; TCP1-chaperonin cofactor A; tubulin cofactor a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013245.3 → NP_001013263.1 tubulin-specific chaperone A

See identical proteins and their annotated locations for NP_001013263.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q6PEC1

UniProtKB/TrEMBL

A0A8I6APW4, A6I4X1

Conserved Domains (1) summary

pfam02970
Location:9 → 95

TBCA; Tubulin binding cofactor A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

27745985..27800624

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282311.1 → XP_063138381.1 tubulin-specific chaperone A isoform X2
XM_039102816.2 → XP_038958744.1 tubulin-specific chaperone A isoform X3

Conserved Domains (1) summary

pfam02970
Location:41 → 87

TBCA; Tubulin binding cofactor A
XM_063282312.1 → XP_063138382.1 tubulin-specific chaperone A isoform X4
XM_063282310.1 → XP_063138380.1 tubulin-specific chaperone A isoform X1

UniProtKB/TrEMBL

A0A8I5ZW23

Related

ENSRNOP00000084980.2, ENSRNOT00000099853.2