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    Dock4 dedicator of cytokinesis 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366608, updated on 2-Nov-2024

    Summary

    Official Symbol
    Dock4provided by RGD
    Official Full Name
    dedicator of cytokinesis 4provided by RGD
    Primary source
    RGD:1561724
    See related
    EnsemblRapid:ENSRNOG00000004823 AllianceGenome:RGD:1561724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynapse. Orthologous to human DOCK4 (dedicator of cytokinesis 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 188.1), Brain (RPKM 147.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dock4 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (63240050..63629772)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (57512929..57902597)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (60374839..60782648)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29-like Neighboring gene interferon-related developmental regulator 1 Neighboring gene uncharacterized LOC120093202 Neighboring gene zinc finger protein 277 Neighboring gene uncharacterized LOC102552766 Neighboring gene inner mitochondrial membrane peptidase subunit 2 Neighboring gene H3.3 histone like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables PDZ domain binding  
    enables guanyl-nucleotide exchange factor activity  
    enables guanyl-nucleotide exchange factor activity  
    enables receptor tyrosine kinase binding  
    enables small GTPase binding  
    enables small GTPase binding  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    is_active_in cytoplasm  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in membrane  
    located_in nucleolus  
    located_in nucleolus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse PubMed 
    is_active_in postsynapse PubMed 
    located_in stereocilium  
    located_in stereocilium bundle  

    General protein information

    Preferred Names
    dedicator of cytokinesis protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427091.1NP_001414020.1  dedicator of cytokinesis protein 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZNR8
      Related
      ENSRNOP00000079532.1, ENSRNOT00000110069.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      63240050..63629772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078130.2XP_038934058.1  dedicator of cytokinesis protein 4 isoform X5

      UniProtKB/TrEMBL
      A6HBD9
      Conserved Domains (4) summary
      cd08695
      Location:400584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd12049
      Location:1065
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69392
      DOCK_N; DOCK N-terminus
      cl06123
      Location:11871227
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
    2. XM_039078128.2XP_038934056.1  dedicator of cytokinesis protein 4 isoform X3

      UniProtKB/TrEMBL
      F1LZ81
      Conserved Domains (4) summary
      cd08695
      Location:400584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:12061596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:1065
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69392
      DOCK_N; DOCK N-terminus
    3. XM_039078129.2XP_038934057.1  dedicator of cytokinesis protein 4 isoform X4

      UniProtKB/TrEMBL
      F1LZ81, M0R6K4
      Related
      ENSRNOP00000065056.3, ENSRNOT00000075193.4
      Conserved Domains (4) summary
      cd08695
      Location:400584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:12061596
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:1065
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69392
      DOCK_N; DOCK N-terminus
    4. XM_039078126.2XP_038934054.1  dedicator of cytokinesis protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXG8, F1LZ81
      Related
      ENSRNOP00000083690.1, ENSRNOT00000112020.2
      Conserved Domains (4) summary
      cd08695
      Location:400584
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:11971587
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:1065
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:69392
      DOCK_N; DOCK N-terminus
    5. XM_039078125.1XP_038934053.1  dedicator of cytokinesis protein 4 isoform X1

      UniProtKB/TrEMBL
      F1LZ81
      Related
      ENSRNOP00000006709.8, ENSRNOT00000006709.10
      Conserved Domains (4) summary
      cd08695
      Location:399583
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11705
      Location:12051595
      DHR2_DOCK4; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 4
      cd12049
      Location:964
      SH3_DOCK4_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 4
      pfam16172
      Location:68391
      DOCK_N; DOCK N-terminus
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