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    Kctd17 potassium channel tetramerization domain containing 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300317, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kctd17provided by RGD
    Official Full Name
    potassium channel tetramerization domain containing 17provided by RGD
    Primary source
    RGD:1311154
    See related
    EnsemblRapid:ENSRNOG00000000231 AllianceGenome:RGD:1311154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311154
    Summary
    Predicted to enable cullin family protein binding activity; identical protein binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in endoplasmic reticulum calcium ion homeostasis; positive regulation of cilium assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in myoclonic dystonia 26. Orthologous to human KCTD17 (potassium channel tetramerization domain containing 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 72.6), Kidney (RPKM 35.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kctd17 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (111859556..111891869)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (109979060..110009091)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119647301..119658148)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene thiosulfate sulfurtransferase Neighboring gene mercaptopyruvate sulfurtransferase Neighboring gene uncharacterized LOC120093822 Neighboring gene transmembrane serine protease 6 Neighboring gene uncharacterized LOC120093823 Neighboring gene interleukin 2 receptor subunit beta Neighboring gene C1q and TNF related 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia. Mencacci NE, et al. Am J Hum Genet, 2015 Jun 4. PMID 25983243, Free PMC Article
    2. Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Kasahara K, et al. Nat Commun, 2014 Oct 1. PMID 25270598, Free PMC Article
    3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein KCTD17
    Names
    potassium channel tetramerisation domain containing 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134529.1 → NP_001128001.1  BTB/POZ domain-containing protein KCTD17 isoform 2

      See identical proteins and their annotated locations for NP_001128001.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HSK3, A6HSK4
      Conserved Domains (2) summary
      smart00225
      Location:32 → 131
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:33 → 121
      BTB_2; BTB/POZ domain

    2. NM_001395732.1 → NP_001382661.1  BTB/POZ domain-containing protein KCTD17 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D3ZYQ0
      Related
      ENSRNOP00000044649.4, ENSRNOT00000046563.4
      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      111859556..111891869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241976.5 → XP_006242038.2  BTB/POZ domain-containing protein KCTD17 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AKZ1
      Related
      ENSRNOP00000093901.2, ENSRNOT00000117512.2

    2. XM_039078951.1 → XP_038934879.1  BTB/POZ domain-containing protein KCTD17 isoform X6

      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    3. XM_006241977.4 → XP_006242039.2  BTB/POZ domain-containing protein KCTD17 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZRW4, A6HSK0, A6HSK4
      Related
      ENSRNOP00000081151.2, ENSRNOT00000105459.2
      Conserved Domains (2) summary
      smart00225
      Location:32 → 131
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:33 → 121
      BTB_2; BTB/POZ domain

    4. XM_039078947.2 → XP_038934875.1  BTB/POZ domain-containing protein KCTD17 isoform X2

      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    5. XM_039078948.2 → XP_038934876.1  BTB/POZ domain-containing protein KCTD17 isoform X3

      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    6. XM_039078954.2 → XP_038934882.1  BTB/POZ domain-containing protein KCTD17 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZZ48, A6HSK4
      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    7. XM_006241983.5 → XP_006242045.2  BTB/POZ domain-containing protein KCTD17 isoform X13

      UniProtKB/TrEMBL
      A6HSK1, A6HSK4
      Conserved Domains (2) summary
      smart00225
      Location:32 → 131
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:33 → 121
      BTB_2; BTB/POZ domain

    8. XM_039078949.2 → XP_038934877.1  BTB/POZ domain-containing protein KCTD17 isoform X5

      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    9. XM_039078952.2 → XP_038934880.1  BTB/POZ domain-containing protein KCTD17 isoform X7

      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    10. XM_039078953.2 → XP_038934881.1  BTB/POZ domain-containing protein KCTD17 isoform X10

      UniProtKB/TrEMBL
      A6HSK4
      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    11. XM_063263392.1 → XP_063119462.1  BTB/POZ domain-containing protein KCTD17 isoform X10

    12. XM_063263391.1 → XP_063119461.1  BTB/POZ domain-containing protein KCTD17 isoform X9

    13. XM_006241978.5 → XP_006242040.2  BTB/POZ domain-containing protein KCTD17 isoform X8

      UniProtKB/TrEMBL
      A0A8I6A664
      Related
      ENSRNOP00000086871.1, ENSRNOT00000114366.2

    14. XM_039078955.2 → XP_038934883.1  BTB/POZ domain-containing protein KCTD17 isoform X14

      UniProtKB/TrEMBL
      A6HSK4
      Conserved Domains (1) summary
      cd18391
      Location:31 → 131
      BTB_POZ_KCTD17; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17)

    15. XM_063263393.1 → XP_063119463.1  BTB/POZ domain-containing protein KCTD17 isoform X12

    Nucleotide Protein Strain
    Heading Accession and Version

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