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    Cenpi centromere protein I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25448, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cenpiprovided by RGD
    Official Full Name
    centromere protein Iprovided by RGD
    Primary source
    RGD:2631
    See related
    EnsemblRapid:ENSRNOG00000033335 AllianceGenome:RGD:2631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRPR1; RNALRP; Fshprh1
    Summary
    Involved in follicle-stimulating hormone signaling pathway. Predicted to be located in kinetochore and nuclear body. Predicted to be part of inner kinetochore. Orthologous to human CENPI (centromere protein I). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 45.1), Thymus (RPKM 39.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cenpi in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (101809192..101860935)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97515919..97567671)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105147045..105198798)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene XK related, X-linked Neighboring gene tRNA methyltransferase 2 homolog B Neighboring gene transmembrane protein 35A Neighboring gene dystrophin related protein 2 Neighboring gene TATA-box binding protein associated factor 7-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein. Slegtenhorst-Eegdeman KE, et al. Mol Cell Endocrinol, 1995 Feb 27. PMID 7758824
    2. The SUMO protease SENP6 is essential for inner kinetochore assembly. Mukhopadhyay D, et al. J Cell Biol, 2010 Mar 8. PMID 20212317, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in CENP-A containing chromatin assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centromere complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in follicle-stimulating hormone signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of inner kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein I
    Names
    CENP-I
    FSH primary response 1
    FSH primary response protein 1
    Follicle stimulating hormone primary response gene 1 (Leucine - rich primary resonse gene 1)
    follicle-stimulating hormone primary response protein
    leucine-rich primary response protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431555.1 → NP_001418484.1  centromere protein I

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IVE9, F1LP20

    2. NM_001431556.1 → NP_001418485.1  centromere protein I

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IVE9, F1LP20

    3. NM_001431557.1 → NP_001418486.1  centromere protein I

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IVE9, F1LP20

    4. NM_012955.1 → NP_037087.1  centromere protein I

      See identical proteins and their annotated locations for NP_037087.1

      Status: PROVISIONAL

      Source sequence(s)
      X90355
      UniProtKB/Swiss-Prot
      Q63517
      UniProtKB/TrEMBL
      A0A0G2K7E6
      Related
      ENSRNOP00000041317.4, ENSRNOT00000046288.6
      Conserved Domains (1) summary
      pfam07778
      Location:12 → 515
      CENP-I; Mis6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      101809192..101860935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257217.5 → XP_006257279.1  centromere protein I isoform X1

      Conserved Domains (1) summary
      pfam07778
      Location:12 → 515
      CENP-I; Mis6

    2. XM_006257215.5 → XP_006257277.1  centromere protein I isoform X1

      Conserved Domains (1) summary
      pfam07778
      Location:12 → 515
      CENP-I; Mis6

    3. XM_039099502.2 → XP_038955430.1  centromere protein I isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7E6
      Conserved Domains (1) summary
      pfam07778
      Location:12 → 515
      CENP-I; Mis6

    4. XM_006257216.5 → XP_006257278.1  centromere protein I isoform X1

      Conserved Domains (1) summary
      pfam07778
      Location:12 → 515
      CENP-I; Mis6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63517.1 GenPept UniProtKB/Swiss-Prot:Q63517

    Gene LinkOut

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