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    Iqce IQ motif containing E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304318, updated on 2-Nov-2024

    Summary

    Official Symbol
    Iqceprovided by RGD
    Official Full Name
    IQ motif containing Eprovided by RGD
    Primary source
    RGD:1311349
    See related
    EnsemblRapid:ENSRNOG00000001241 AllianceGenome:RGD:1311349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311349
    Summary
    Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; protein localization to motile cilium; and regulation of smoothened signaling pathway. Predicted to be located in ciliary membrane and cytoplasmic side of plasma membrane. Predicted to be part of plasma membrane protein complex. Orthologous to human IQCE (IQ motif containing E). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 102.7), Kidney (RPKM 27.1) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Iqce in Genome Data Viewer
    Location:
    12q11
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19057060..19096626)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13943290..13982708)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16030607..16069872)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 12 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene tweety family member 3 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in ciliary membrane  
    located_in cytoplasmic side of plasma membrane  
    part_of plasma membrane protein complex  

    General protein information

    Preferred Names
    IQ domain-containing protein E

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432060.1NP_001418989.1  IQ domain-containing protein E isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6B1N9
    2. NM_001432061.1NP_001418990.1  IQ domain-containing protein E isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      D3ZUL9
    3. NM_001432062.1NP_001418991.1  IQ domain-containing protein E isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1R7
    4. NM_001432064.1NP_001418993.1  IQ domain-containing protein E isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    5. NM_001432065.1NP_001418994.1  IQ domain-containing protein E isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    6. NM_001432066.1NP_001418995.1  IQ domain-containing protein E isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    7. NM_001432067.1NP_001418996.1  IQ domain-containing protein E isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    8. NM_001432068.1NP_001418997.1  IQ domain-containing protein E isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    9. NM_001432069.1NP_001418998.1  IQ domain-containing protein E isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    10. NM_001432070.1NP_001418999.1  IQ domain-containing protein E isoform 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    11. NM_001432071.1NP_001419000.1  IQ domain-containing protein E isoform 11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    12. NM_001432072.1NP_001419001.1  IQ domain-containing protein E isoform 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    13. NM_001432073.1NP_001419002.1  IQ domain-containing protein E isoform 13

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    14. NM_001432074.1NP_001419003.1  IQ domain-containing protein E isoform 14

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    15. NM_001432075.1NP_001419004.1  IQ domain-containing protein E isoform 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
    16. NM_001432076.1NP_001419005.1  IQ domain-containing protein E isoform 16

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19057060..19096626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598488.3XP_017453977.1  IQ domain-containing protein E isoform X1

    2. XM_017598489.3XP_017453978.1  IQ domain-containing protein E isoform X3

    3. XM_017598490.3XP_017453979.1  IQ domain-containing protein E isoform X5

    4. XM_006248962.5XP_006249024.1  IQ domain-containing protein E isoform X2

      See identical proteins and their annotated locations for XP_006249024.1

      Conserved Domains (3) summary
      smart00015
      Location:561581
      IQ; Calmodulin-binding motif
      pfam16043
      Location:423477
      DUF4795; Domain of unknown function (DUF4795)
      pfam16046
      Location:347478
      FAM76; FAM76 protein
    5. XM_063271863.1XP_063127933.1  IQ domain-containing protein E isoform X4

      Related
      ENSRNOP00000094917.1, ENSRNOT00000117335.2
    6. XM_221965.10XP_221965.5  IQ domain-containing protein E isoform X6

      See identical proteins and their annotated locations for XP_221965.5

      UniProtKB/TrEMBL
      D4ADQ3
      Related
      ENSRNOP00000040350.5, ENSRNOT00000051565.8
      Conserved Domains (3) summary
      smart00015
      Location:561581
      IQ; Calmodulin-binding motif
      pfam16043
      Location:423477
      DUF4795; Domain of unknown function (DUF4795)
      pfam16046
      Location:347478
      FAM76; FAM76 protein
    7. XM_017598491.3XP_017453980.1  IQ domain-containing protein E isoform X7

    8. XM_063271865.1XP_063127935.1  IQ domain-containing protein E isoform X9

    9. XM_063271866.1XP_063127936.1  IQ domain-containing protein E isoform X12

    10. XM_063271864.1XP_063127934.1  IQ domain-containing protein E isoform X8

    11. XM_039089960.2XP_038945888.1  IQ domain-containing protein E isoform X10

      Related
      ENSRNOP00000111353.1, ENSRNOT00000130050.1
      Conserved Domains (2) summary
      smart00015
      Location:516536
      IQ; Calmodulin-binding motif
      COG1196
      Location:167465
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    12. XM_063271867.1XP_063127937.1  IQ domain-containing protein E isoform X13

    13. XM_039089961.2XP_038945889.1  IQ domain-containing protein E isoform X17

      Conserved Domains (2) summary
      smart00015
      Location:563584
      IQ; Calmodulin-binding motif
      COG1196
      Location:212510
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    14. XM_063271870.1XP_063127940.1  IQ domain-containing protein E isoform X18

    15. XM_017598492.3XP_017453981.1  IQ domain-containing protein E isoform X11

      Related
      ENSRNOP00000001667.8, ENSRNOT00000001667.8
    16. XM_017598494.3XP_017453983.1  IQ domain-containing protein E isoform X19

    17. XM_063271872.1XP_063127942.1  IQ domain-containing protein E isoform X21

    18. XM_017598493.3XP_017453982.1  IQ domain-containing protein E isoform X14

    19. XM_063271868.1XP_063127938.1  IQ domain-containing protein E isoform X15

    20. XM_063271869.1XP_063127939.1  IQ domain-containing protein E isoform X16

    21. XM_063271871.1XP_063127941.1  IQ domain-containing protein E isoform X20

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