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    TRAM1 translocation associated membrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 23471, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TRAM1provided by HGNC
    Official Full Name
    translocation associated membrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:20568
    See related
    Ensembl:ENSG00000067167 MIM:605190; AllianceGenome:HGNC:20568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRAM; PNAS8; TRAMP
    Summary
    This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 96.1), urinary bladder (RPKM 71.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRAM1 in Genome Data Viewer
    Location:
    8q13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (70573218..70608416, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (71003150..71038323, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (71485453..71520651, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375890 Neighboring gene ribosomal protein L13 pseudogene 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:71453867-71454367 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27508 Neighboring gene LACTB2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27510 Neighboring gene lactamase beta 2 Neighboring gene RNA, 7SL, cytoplasmic 19, pseudogene Neighboring gene XK related 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:71660008-71660508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27511 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:71716960-71717817 Neighboring gene uncharacterized LOC124901960

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Protein translocation. Travelling by TRAM. Walter P. Nature, 1992 May 7. PMID 1315419
    2. TRAM1 is involved in disposal of ER membrane degradation substrates. Ng CL, et al. Exp Cell Res, 2010 Aug 1. PMID 20430023, Free PMC Article
    3. TRAM1 protect HepG2 cells from palmitate induced insulin resistance through ER stress-JNK pathway. Tang Z, et al. Biochem Biophys Res Commun, 2015 Feb 20. PMID 25600807
    4. The human TRAM1 locus expresses circular RNAs. Dubois J, et al. Sci Rep, 2021 Nov 11. PMID 34764360, Free PMC Article
    5. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum. Hegde RS, et al. Cell, 1998 Mar 6. PMID 9506517

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication.
      Title: The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication.
    2. Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog.
      Title: Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog.
    3. The human TRAM1 locus expresses circular RNAs.
      Title: The human TRAM1 locus expresses circular RNAs.
    4. TRAM1 protect HepG2 cells from palmitate-induced insulin resistance. The protection of TRAM1 to HepG2 cells is through endoplasmic reticulum stress-JNK pathway.
      Title: TRAM1 protect HepG2 cells from palmitate induced insulin resistance through ER stress-JNK pathway.
    5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • PRO1292

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cotranslational protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into ER membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translocating chain-associated membrane protein 1
    Names
    translocating chain-associating membrane protein
    translocation-associating membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317804.2 → NP_001304733.1  translocating chain-associated membrane protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA740941, AC120194, AK303411, BC032018, BC037738, BQ233660, DB448315
      UniProtKB/TrEMBL
      Q6FHU7
      Conserved Domains (2) summary
      smart00724
      Location:86 → 295
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:19 → 84
      TRAM1; TRAM1-like protein

    2. NM_001317805.2 → NP_001304734.1  translocating chain-associated membrane protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA740941, AC120194, AK303411, BC032018, BC037738, BQ233660
      Consensus CDS
      CCDS83300.1
      UniProtKB/TrEMBL
      G3XAN4
      Related
      ENSP00000428052.1, ENST00000521425.5
      Conserved Domains (2) summary
      smart00724
      Location:31 → 240
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:1 → 29
      TRAM1; TRAM1-like protein

    3. NM_014294.6 → NP_055109.1  translocating chain-associated membrane protein 1 isoform 1

      See identical proteins and their annotated locations for NP_055109.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA740941, AC120194, BC037738, BI465346, DB448315
      Consensus CDS
      CCDS6207.1
      UniProtKB/Swiss-Prot
      B4E0K2, Q15629
      UniProtKB/TrEMBL
      Q6FHL3, Q6FHU7
      Related
      ENSP00000262213.2, ENST00000262213.7
      Conserved Domains (2) summary
      smart00724
      Location:117 → 326
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:50 → 115
      TRAM1; TRAM1-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      70573218..70608416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421636.1 → XP_047277592.1  translocating chain-associated membrane protein 1 isoform X1

      UniProtKB/TrEMBL
      G3XAN4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      71003150..71038323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15629.3 GenPept UniProtKB/Swiss-Prot:Q15629

    Gene LinkOut

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