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    APOE apolipoprotein E [ Kogia breviceps (pygmy sperm whale) ]

    Gene ID: 131744745, updated on 2-Aug-2024

    Summary

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    Gene symbol
    APOE
    Gene description
    apolipoprotein E
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Kogia breviceps
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Physeteridae; Kogia
    Orthologs
    human mouse all
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    Genomic context

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    See APOE in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_07 current mKogBre1 haplotype 1 (GCF_026419965.1) 18 NC_081327.1 (9238418..9241211, complement)

    Chromosome 18 - NC_081327.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein C2 Neighboring gene apolipoprotein C4 Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene nectin cell adhesion molecule 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_081327.1 Chromosome 18 Reference mKogBre1 haplotype 1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables very-low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipoprotein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of nitric-oxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of amyloid-beta clearance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of intermediate-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    apolipoprotein E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_026419965.1-RS_2024_07

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mKogBre1 haplotype 1 Primary Assembly

    Genomic

    1. NC_081327.1 Reference mKogBre1 haplotype 1 Primary Assembly

      Range
      9238418..9241211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059044567.2 → XP_058900550.1  apolipoprotein E isoform X2

    2. XM_059044566.2 → XP_058900549.1  apolipoprotein E isoform X1

    Nucleotide Protein
    Heading Accession and Version

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