Kcnh2 potassium voltage-gated channel subfamily H member 2 [Cavia porcellus (domestic guinea pig)] - Gene

Summary

Gene symbol: Kcnh2
Gene description: potassium voltage-gated channel subfamily H member 2
See related: Ensembl:ENSCPOG00000022750
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Cavia porcellus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Also known as: ERG; gp-erg
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	mCavPor4.1 (GCF_034190915.1)	Unplaced Scaffold	NW_026947489.1 (56917174..56959971, complement)
103	previous assembly	Cavpor3.0 (GCF_000151735.1)	Unplaced Scaffold	NT_176387.1 (682122..707956, complement)

NW_026947489.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data suggest that CO induces arrhythmias in guinea pig cardiac myocytes via the ONOO(-)-mediated inhibition of Kv11.1 K(+) channels
Title: A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K(+) channels in carbon monoxide-induced proarrhythmic early afterdepolarizations.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in membrane repolarization during action potential	IEA Inferred from Electronic Annotation more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: voltage-gated inwardly rectifying potassium channel KCNH2; potassium voltage-gated channel subfamily H member 2

Names: ERG-1; eag-related protein 1; ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related protein 1; potassium channel protein ERG; potassium voltage-gated channel, subfamily H (eag-related), member 2; voltage-gated potassium channel subunit Kv11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172973.1 → NP_001166444.1 voltage-gated inwardly rectifying potassium channel KCNH2

See identical proteins and their annotated locations for NP_001166444.1

Status: PROVISIONAL

Source sequence(s)

EF204534

UniProtKB/TrEMBL

A6Y9U1, H0VXS3

Related

ENSCPOP00000015503.2, ENSCPOT00000027897.2

Conserved Domains (7) summary

COG0664
Location:736 → 856

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:742 → 853

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:41 → 132

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:449 → 668

Ion_trans; Ion transport protein

pfam07885
Location:611 → 665

Ion_trans_2; Ion channel

pfam13426
Location:29 → 130

PAS_9; PAS domain

pfam15836
Location:1011 → 1112

SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

NW_026947489.1 Reference mCavPor4.1

Range

56917174..56959971 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063249514.1 → XP_063105584.1 potassium voltage-gated channel subfamily H member 2 isoform X1
XM_063249515.1 → XP_063105585.1 potassium voltage-gated channel subfamily H member 2 isoform X2
XM_063249516.1 → XP_063105586.1 potassium voltage-gated channel subfamily H member 2 isoform X3