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    MOB2 Mob2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850508, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MOB2
    Official Full Name
    Mob2p
    Primary source
    SGD:S000001859
    Locus tag
    YFL034C-B
    See related
    AllianceGenome:SGD:S000001859; FungiDB:YFL034C-B; VEuPathDB:YFL034C-B
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YFL035C; YFL035C-A
    Summary
    Enables protein kinase activator activity. Involved in several processes, including budding cell apical bud growth; positive regulation of protein phosphorylation; and septum digestion after cytokinesis. Located in several cellular components, including cellular bud neck; cellular bud tip; and mating projection tip. Orthologous to human MOB2 (MOB kinase activator 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MOB2 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    2
    Sequence:
    Chromosome: VI; NC_001138.5 (63016..63993, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase Neighboring gene ribosomal 60S subunit protein L22B Neighboring gene Mil1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional analysis of Saccharomyces cerevisiae Mob1. Mrkobrada S, et al. J Mol Biol, 2006 Sep 22. PMID 16934835
    2. The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor. Weiss EL, et al. J Cell Biol, 2002 Sep 2. PMID 12196508, Free PMC Article
    3. Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface. Parker BW, et al. Biochemistry, 2020 May 5. PMID 32250593, Free PMC Article
    4. The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Gógl G, et al. PLoS Biol, 2015 May. PMID 25966461, Free PMC Article
    5. MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy. Luca FC, et al. Mol Biol Cell, 1998 Jan. PMID 9436989, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in budding cell apical bud growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in budding cell apical bud growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mob2p
    NP_116618.1
    • Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      63016..63993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179931.1 → NP_116618.1  TPA: Mob2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116618.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTJ5, P43563
      UniProtKB/TrEMBL
      A7A204, B3LUH6, C8Z7P7, N1P330
      Conserved Domains (1) summary
      pfam03637
      Location:102 → 271
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43563.2

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