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    VIK1 Vik1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855822, updated on 2-Nov-2024

    Summary

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    Official Symbol
    VIK1
    Official Full Name
    Vik1p
    Primary source
    SGD:S000006174
    Locus tag
    YPL253C
    See related
    AllianceGenome:SGD:S000006174; FungiDB:YPL253C; VEuPathDB:YPL253C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables microtubule binding activity. Involved in microtubule-based process and mitotic sister chromatid cohesion. Acts upstream of or within microtubule nucleation. Located in spindle pole body. Part of kinesin complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See VIK1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (71063..73006, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Bbp1p Neighboring gene Hfi1p Neighboring gene adrenodoxin Neighboring gene Atg41p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1. Duan D, et al. J Biol Chem, 2012 Nov 23. PMID 23043140, Free PMC Article
    2. Cryo-electron tomography of microtubule-kinesin motor complexes. Cope J, et al. J Struct Biol, 2010 May. PMID 20025975, Free PMC Article
    3. Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site. Allingham JS, et al. Cell, 2007 Mar 23. PMID 17382884, Free PMC Article
    4. The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae. Shanks RM, et al. Genetics, 2001 Nov. PMID 11729143, Free PMC Article
    5. The ATPase pathway that drives the kinesin-14 Kar3Vik1 powerstroke. Chen CJ, et al. J Biol Chem, 2012 Oct 26. PMID 22977241, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neck rotation and neck mimic docking in Vik1 and Cik1 is a structural mechanism for communication with Kar3.
      Title: Neck rotation and neck mimic docking in the noncatalytic Kar3-associated protein Vik1.
    2. Rapid ATP binding to Kar3 is associated with rotation of the coiled-coil stalk, and the postpowerstroke ATP hydrolysis is independent of Vik1.
      Title: The ATPase pathway that drives the kinesin-14 Kar3Vik1 powerstroke.
    3. show through structural determination of a C-terminal heterodimeric Kar3Vik1, electron microscopy, equilibrium binding, and motility that at the start of the cycle, Kar3Vik1 binds to or occludes two alphabeta-tubulin subunits on adjacent protofilaments
      Title: Kar3Vik1, a member of the kinesin-14 superfamily, shows a novel kinesin microtubule binding pattern.
    4. Vik1 binds more tightly to microtubules than Kar3 and facilitates cooperative microtubule decoration by Kar3/Vik1 heterodimers, and yet allows motility.
      Title: Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vik1p
    NP_015070.1
    • Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      71063..73006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184067.1 → NP_015070.1  TPA: Vik1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015070.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3B8, Q12045, Q7LGU6
      UniProtKB/TrEMBL
      A6ZW03, C7GTR0, N1NVH9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12045.1

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