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    PRM3 pheromone-regulated protein PRM3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855909, updated on 17-May-2024

    Summary

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    Gene symbol
    PRM3
    Gene description
    pheromone-regulated protein PRM3
    Primary source
    FungiDB:YPL192C
    Locus tag
    YPL192C
    See related
    SGD:S000006113; AllianceGenome:SGD:S000006113; VEuPathDB:YPL192C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in karyogamy involved in conjugation with cellular fusion and nuclear membrane fusion involved in karyogamy. Located in nuclear envelope and spindle pole body. Is extrinsic component of nuclear outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PRM3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (182655..183056, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ddc1p Neighboring gene Rsa1p Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene Nab3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion. Shen S, et al. Mol Biol Cell, 2009 May. PMID 19297527, Free PMC Article
    2. Compartmentalization of ER-Bound Chaperone Confines Protein Deposit Formation to the Aging Yeast Cell. Saarikangas J, et al. Curr Biol, 2017 Mar 20. PMID 28262489
    3. Distinct roles for key karyogamy proteins during yeast nuclear fusion. Melloy P, et al. Mol Biol Cell, 2009 Sep. PMID 19570912, Free PMC Article
    4. Organizational constraints on Ste12 cis-elements for a pheromone response in Saccharomyces cerevisiae. Su TC, et al. FEBS J, 2010 Aug. PMID 20584076
    5. Kar5p is required for multiple functions in both inner and outer nuclear envelope fusion in Saccharomyces cerevisiae. Rogers JV, et al. G3 (Bethesda), 2014 Dec 2. PMID 25467943, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prm3p interacts directly with Kar5p, suggesting that nuclear membrane fusion is mediated by a protein complex.
      Title: Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in karyogamy involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear membrane fusion involved in karyogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pheromone-regulated protein PRM3
    NP_015132.1
    • Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the spindle pole body

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      182655..183056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184006.1 → NP_015132.1  TPA: pheromone-regulated protein PRM3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015132.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3H6, Q08931
      UniProtKB/TrEMBL
      A0A7I9C6M6, A6ZW61, C7GTT2, C8ZII7, G2WNZ1, N1P2M9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08931.1

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