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    ARL3 Arf family GTPase ARL3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856056, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ARL3
    Official Full Name
    Arf family GTPase ARL3
    Primary source
    SGD:S000005972
    Locus tag
    YPL051W
    See related
    AllianceGenome:SGD:S000005972; FungiDB:YPL051W; VEuPathDB:YPL051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity. Involved in protein localization to Golgi apparatus; protein transport; and response to endoplasmic reticulum stress. Located in Golgi apparatus and nuclear outer membrane-endoplasmic reticulum membrane network. Orthologous to human ARFRP1 (ADP ribosylation factor related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ARL3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (459963..460559)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative mannosyltransferase Neighboring gene Oaz1p Neighboring gene mannosyltransferase complex subunit MNN9 Neighboring gene Dig1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Setty SR, et al. Curr Biol, 2003 Mar 4. PMID 12620188
    2. Characterization of a novel ADP-ribosylation factor-like protein (yARL3) in Saccharomyces cerevisiae. Huang CF, et al. J Biol Chem, 1999 Feb 5. PMID 9920936
    3. The Arl3 and Arl1 GTPases co-operate with Cog8 to regulate selective autophagy via Atg9 trafficking. Wang IH, et al. Traffic, 2017 Sep. PMID 28627726
    4. Competition between the golgin Imh1p and the GAP Gcs1p stabilizes activated Arl1p at the late-Golgi. Chen KY, et al. J Cell Sci, 2012 Oct 1. PMID 22767516
    5. Mutational analysis of the yeast TRAPP subunit Trs20p identifies roles in endocytic recycling and sporulation. Mahfouz H, et al. PLoS One, 2012. PMID 23049729, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atg9 accumulates at the late Golgi in arl3cog8Delta and arl1cog8Delta cells under normal growth conditions but not under starvation conditions
      Title: The Arl3 and Arl1 GTPases co-operate with Cog8 to regulate selective autophagy via Atg9 trafficking.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Arf family GTPase ARL3
    NP_015274.1
    • ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      459963..460559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183865.1 → NP_015274.1  TPA: Arf family GTPase ARL3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3W3, Q02804
      UniProtKB/TrEMBL
      A6ZWJ7, B3LL16, B5VTA9, C7GU03, C8ZIX8, G2WPC7, N1NVY8
      Conserved Domains (1) summary
      cd04160
      Location:19 → 185
      Arfrp1; Arf-related protein 1 (Arfrp1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02804.1

    Gene LinkOut

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