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    MCM16 Mcm16p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856159, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MCM16
    Official Full Name
    Mcm16p
    Primary source
    SGD:S000006250
    Locus tag
    YPR046W
    See related
    AllianceGenome:SGD:S000006250; FungiDB:YPR046W; VEuPathDB:YPR046W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in chromosome segregation and establishment of mitotic sister chromatid cohesion. Located in kinetochore. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MCM16 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (656799..657344)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L43A Neighboring gene Thp3p Neighboring gene phenylalanine--tRNA ligase Neighboring gene NAPDH-dependent diflavin reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MCM16 gene of the yeast Saccharomyces cerevisiae is required for chromosome segregation. Sanyal K, et al. Mol Gen Genet, 1998 Nov. PMID 9862478
    2. The structure of the yeast Ctf3 complex. Hinshaw SM, et al. Elife, 2019 Jun 13. PMID 31194673, Free PMC Article
    3. Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex. Zhang Z, et al. Nucleic Acids Res, 2020 Nov 4. PMID 32976599, Free PMC Article
    4. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Ghosh SK, et al. Mol Genet Genomics, 2001 Apr. PMID 11361335
    5. Kar9 controls the nucleocytoplasmic distribution of yeast EB1. Schweiggert J, et al. Cell Cycle, 2016 Nov. PMID 27625073, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mcm16p
    NP_015371.1
    • Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      656799..657344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184143.1 → NP_015371.1  TPA: Mcm16p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015371.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W454, Q12262
      UniProtKB/TrEMBL
      A6ZWT7, B5VTK0, C7GY35, C8ZJ71, N1NWA9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12262.1

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