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    FRMD8P1 FERM domain containing 8 pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 83957, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FRMD8P1provided by HGNC
    Official Full Name
    FERM domain containing 8 pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:24690
    See related
    Ensembl:ENSG00000227942 AllianceGenome:HGNC:24690
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in cytoskeleton. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FRMD8P1 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (65550622..65552421, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (63977061..63978860, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (64770502..64772301, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 12B Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:64713210-64713789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:64722192-64722692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:64722693-64723193 Neighboring gene AP1M2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29713 Neighboring gene LAS1 like ribosome biogenesis factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20881 Neighboring gene moesin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29715 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:64924017-64924189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29716 Neighboring gene Sharpr-MPRA regulatory region 13592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29717 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:64972237-64972435 Neighboring gene Nanog homeobox pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article
    2. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • FERM domain-containing protein 8 pseudogene
    • FKSG43
    • Putative FERM domain-containing protein FRMD8P1

    Clone Names

    • MGC149236

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_033742.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL050306, BC128150
      Related
      ENST00000440433.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      65550622..65552421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      63977061..63978860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_004716.3: Suppressed sequence

      Description
      NG_004716.3: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

    2. NG_026711.1: Suppressed sequence

      Description
      NG_026711.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

    3. NM_032033.1: Suppressed sequence

      Description
      NM_032033.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZ68.2 GenPept UniProtKB/Swiss-Prot:Q9BZ68

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials