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    Clic3 chloride intracellular channel 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296566, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Clic3provided by RGD
    Official Full Name
    chloride intracellular channel 3provided by RGD
    Primary source
    RGD:1307249
    See related
    EnsemblRapid:ENSRNOG00000015184 AllianceGenome:RGD:1307249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chloride channel activity and protein-disulfide reductase (glutathione) activity. Predicted to be involved in chloride transport and positive regulation of sprouting angiogenesis. Predicted to be located in extracellular matrix and nuclear body. Predicted to be part of chloride channel complex. Predicted to be active in cytoplasm and membrane. Orthologous to human CLIC3 (chloride intracellular channel 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 254.3), Kidney (RPKM 56.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clic3 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28670176..28672166)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8271416..8274023)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2675732..2678248)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 7 Neighboring gene ATP binding cassette subfamily A member 2 Neighboring gene PAXX, non-homologous end joining factor Neighboring gene prostaglandin D2 synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel. Qian Z, et al. J Biol Chem, 1999 Jan 15. PMID 9880541
    2. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109225

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase (glutathione) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chloride intracellular channel protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013080.2 → NP_001013098.2  chloride intracellular channel protein 3

      See identical proteins and their annotated locations for NP_001013098.2

      Status: VALIDATED

      Source sequence(s)
      CF115110, CK841958
      UniProtKB/TrEMBL
      A0A8I5ZSV9, A6JT62, D3ZY91
      Related
      ENSRNOP00000081757.1, ENSRNOT00000095258.2
      Conserved Domains (1) summary
      TIGR00862
      Location:6 → 230
      O-ClC; intracellular chloride channel protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28670176..28672166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233590.5 → XP_006233652.1  chloride intracellular channel protein 3 isoform X1

      Conserved Domains (2) summary
      cd10299
      Location:69 → 201
      GST_C_CLIC3; C-terminal, alpha helical domain of Chloride Intracellular Channel 3
      cl00388
      Location:1 → 62
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein Strain
    Heading Accession and Version

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