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    USP17L9P ubiquitin specific peptidase 17 like family member 9, pseudogene [ Homo sapiens (human) ]

    Gene ID: 391627, updated on 27-Aug-2024

    Summary

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    Official Symbol
    USP17L9Pprovided by HGNC
    Official Full Name
    ubiquitin specific peptidase 17 like family member 9, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:12615
    See related
    Ensembl:ENSG00000251694 MIM:607011; AllianceGenome:HGNC:12615
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RS447; USP17; USP17A; USP17H; USP17I; USP17J; USP17K; USP17L; USP17M
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    Genomic context

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    Location:
    4p16.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (9358382..9359974)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (9378904..9380496)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (9360108..9361700)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 17 like family member 28 Neighboring gene ubiquitin specific peptidase 17 like family member 29 Neighboring gene ubiquitin specific peptidase 17 like family member 30 Neighboring gene ubiquitin specific peptidase 17 like family member 6, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme. Hjortland NM, et al. Arch Biochem Biophys, 2016 Dec 15. PMID 27756680, Free PMC Article
    2. Suppression of Ubiquitin-Specific Peptidase 17 (USP17) Inhibits Tumorigenesis and Invasion in Non-Small Cell Lung Cancer Cells. Zhang S, et al. Oncol Res, 2016. PMID 27656837, Free PMC Article
    3. The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis. McFarlane C, et al. Oncotarget, 2013 Oct. PMID 24123619, Free PMC Article
    4. A novel tandem repeat sequence located on human chromosome 4p: isolation and characterization. Kogi M, et al. Genomics, 1997 Jun 1. PMID 9192848
    5. The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis. Nagasaka M, et al. FEBS Lett, 2022 Feb. PMID 35076962

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP17 regulates preeclampsia by modulating the NF-kappaB signaling pathway via deubiquitinating HDAC2.
      Title: USP17 regulates preeclampsia by modulating the NF-κB signaling pathway via deubiquitinating HDAC2.
    2. The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis.
      Title: The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis.
    3. Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRbeta and affect PDGF-BB-induced STAT3 signalling.
      Title: Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling.
    4. Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
      Title: Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.
    5. our results show that ubiquitination of ELK-1 at K35, and its reversal by USP17, are important mechanisms in the regulation of nuclear ERK signalling and cellular proliferation. Our findings will be relevant for tumours that exhibit elevated USP17 expression and suggest a new target for intervention.
      Title: De-ubiquitination of ELK-1 by USP17 potentiates mitogenic gene expression and cell proliferation.
    6. USP17L9P expression is significantly increased in healthy palatal mucosa of smokers
      Title: Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.
    7. USP17 facilitates trafficking and oncogenic signaling of mutant EGFR
      Title: USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells.
    8. MAD4 has been found to regulate epithelial-mesenchymal transition, co-immunopurification, and glutathione S-transferase pull-down analysis demonstrated that USP17 interacted with SMAD4. Furthermore, USP17 stabilized SMAD4 through its deubiquitinase activity. In conclusion, this study shows that USP17 enhances osteosarcoma cell proliferation and invasion through stabilizing SMAD4.
      Title: USP17 is upregulated in osteosarcoma and promotes cell proliferation, metastasis, and epithelial-mesenchymal transition through stabilizing SMAD4.
    9. Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme
      Title: Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme.
    10. USP17 knockdown significantly suppressed the tumorigenesis ability of both the NSCLC cell lines A549 and H1299. Moreover, USP17 participated in the invasion of NSCLC cells. These functions of USP17 are partially mediated by regulating the expression of MMP proteins MMP3 and MMP9.
      Title: Suppression of Ubiquitin-Specific Peptidase 17 (USP17) Inhibits Tumorigenesis and Invasion in Non-Small Cell Lung Cancer Cells.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • deubiquitinating enzyme 17
    • ubiquitin carboxyl-terminal hydrolase 17
    • ubiquitin specific protease 17
    • ubiquitin thioesterase 17
    • ubiquitin thiolesterase 17
    • ubiquitin-specific-processing protease 17

    Clone Names

    • MGC119330, MGC119331, MGC119333

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_046416.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116655
      Related
      ENST00000508843.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      9358382..9359974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      9378904..9380496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105662.1: Suppressed sequence

      Description
      NM_001105662.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version

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    Chemical Information
    Molecular Biology Databases
    Research Materials