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    MBOAT2 membrane bound O-acyltransferase domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 129642, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MBOAT2provided by HGNC
    Official Full Name
    membrane bound O-acyltransferase domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:25193
    See related
    Ensembl:ENSG00000143797 MIM:611949; AllianceGenome:HGNC:25193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPAAT; LPCAT; LPEAT; OACT2; LPCAT4; LPLAT 2; LPLAT13
    Summary
    Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in bone marrow (RPKM 14.5), brain (RPKM 13.4) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MBOAT2 in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (8852690..9003684, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (8876443..9027457, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (8992820..9143813, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8824708-8825498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8825499-8826288 Neighboring gene inhibitor of DNA binding 2 Neighboring gene kinase D interacting substrate 220 Neighboring gene ARF like GTPase 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11130 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11129 Neighboring gene Sharpr-MPRA regulatory region 5743 Neighboring gene NANOG hESC enhancer GRCh37_chr2:8995048-8995599 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 6065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11131 Neighboring gene uncharacterized LOC124907728 Neighboring gene high mobility group box 1 pseudogene 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer. Zhou X, et al. J Exp Clin Cancer Res, 2021 Apr 8. PMID 33832516, Free PMC Article
    2. CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export. Yu X, et al. Cell Death Dis, 2023 Jan 12. PMID 36635270, Free PMC Article
    3. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. Gijón MA, et al. J Biol Chem, 2008 Oct 31. PMID 18772128, Free PMC Article
    4. LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. Tamaki H, et al. J Biol Chem, 2007 Nov 23. PMID 17890783
    5. The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion. Swayampakula M, et al. Oncogene, 2017 Nov 9. PMID 28692057, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
      Title: CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.
    2. Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer.
      Title: Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14415, FLJ90298

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-acylglycerophosphoserine O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 2-acylglycerol-3-phosphate O-acyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylcholine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine acyl-chain remodeling TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylserine acyl-chain remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chondrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysophospholipid acyltransferase 2
    Names
    1-acylglycerophosphate O-acyltransferase
    1-acylglycerophosphate O-acyltransferase MBOAT2
    1-acylglycerophosphocholine O-acyltransferase MBOAT2
    1-acylglycerophosphoethanolamine MBOAT2 O-acyltransferase
    1-acylglycerophosphoethanolamine O-acyltransferase
    O-acyltransferase (membrane bound) domain containing 2
    lyso-PA acyltransferase
    lyso-PC acyltransferase
    lyso-PC acyltransferase 4
    lyso-PE acyltransferase
    lysophosphatidic acid acyltransferase
    lysophosphatidylcholine acyltransferase
    lysophosphatidylcholine acyltransferase 4
    lysophosphatidylethanolamine acyltransferase
    lysophospholipid acyltransferase 13
    membrane-bound O-acyltransferase domain-containing protein 2
    NP_001308194.1
    NP_001308195.1
    NP_001308196.1
    NP_620154.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321265.2 → NP_001308194.1  lysophospholipid acyltransferase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723
      UniProtKB/TrEMBL
      B0AZU0
      Conserved Domains (1) summary
      cl00738
      Location:14 → 361
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    2. NM_001321266.2 → NP_001308195.1  lysophospholipid acyltransferase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723
      UniProtKB/Swiss-Prot
      Q6ZWT7
      Conserved Domains (1) summary
      cl00738
      Location:1 → 317
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    3. NM_001321267.2 → NP_001308196.1  lysophospholipid acyltransferase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723
      UniProtKB/TrEMBL
      B0AZU0
      Conserved Domains (1) summary
      cl00738
      Location:14 → 361
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    4. NM_138799.4 → NP_620154.2  lysophospholipid acyltransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_620154.2

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723
      Consensus CDS
      CCDS1660.1
      UniProtKB/Swiss-Prot
      A9EDR2, Q6ZWT7, Q8NCE7, Q96KY4
      Related
      ENSP00000302177.3, ENST00000305997.8
      Conserved Domains (1) summary
      cl00738
      Location:13 → 450
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    RNA

    1. NR_135598.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    2. NR_135599.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    3. NR_135600.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    4. NR_135601.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    5. NR_135602.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    6. NR_135603.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    7. NR_135604.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    8. NR_135605.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    9. NR_135606.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC012495, AC112723

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      8852690..9003684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      8876443..9027457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWT7.2 GenPept UniProtKB/Swiss-Prot:Q6ZWT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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