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    Prlr prolactin receptor [ Mus musculus (house mouse) ]

    Gene ID: 19116, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Prlrprovided by MGI
    Official Full Name
    prolactin receptorprovided by MGI
    Primary source
    MGI:MGI:97763
    See related
    Ensembl:ENSMUSG00000005268 AllianceGenome:MGI:97763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pr-1; Pr-3; Prlr-rs1
    Summary
    Enables prolactin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cell surface receptor signaling pathway via JAK-STAT; mammary gland development; and prostate gland growth. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 9.9), liver adult (RPKM 9.8) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prlr in Genome Data Viewer
    Location:
    15 A1; 15 5.23 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10177324..10349276)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10177238..10349190)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene interleukin 7 receptor Neighboring gene sperm flagellar 2 Neighboring gene STARR-seq mESC enhancer starr_37942 Neighboring gene STARR-seq mESC enhancer starr_37943 Neighboring gene STARR-seq mESC enhancer starr_37944 Neighboring gene STARR-seq mESC enhancer starr_37946 Neighboring gene STARR-positive B cell enhancer ABC_E9157 Neighboring gene STARR-seq mESC enhancer starr_37947 Neighboring gene STARR-seq mESC enhancer starr_37948 Neighboring gene STARR-seq mESC enhancer starr_37949 Neighboring gene STARR-seq mESC enhancer starr_37950 Neighboring gene predicted gene, 41268 Neighboring gene predicted gene, 41269 Neighboring gene alanine-glyoxylate aminotransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The hormone prolactin is a novel, endogenous trophic factor able to regulate reactive glia and to limit retinal degeneration. Arnold E, et al. J Neurosci, 2014 Jan 29. PMID 24478366, Free PMC Article
    2. Generation of mice expressing only the long form of the prolactin receptor reveals that both isoforms of the receptor are required for normal ovarian function. Le JA, et al. Biol Reprod, 2012 Mar. PMID 22190699, Free PMC Article
    3. Prolactin receptor expression in the developing mouse embryo. Tzeng SJ, et al. Mol Reprod Dev, 1997 Sep. PMID 9266760
    4. Removal of milk by suckling acutely increases the prolactin receptor gene expression in the lactating mouse mammary gland. Kim JY, et al. Mol Cell Endocrinol, 1997 Jul 4. PMID 9256361
    5. Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-diet-induced obesity. Auffret J, et al. FASEB J, 2012 Sep. PMID 22637534

    See all (193) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance.
      Title: PRL-R Variants Are Not Only Associated With Prolactinomas But Also With Dopamine Agonist Resistance.
    2. [Prolactin and its receptor: From animal models to pituitary pathophysiology].
      Title: [Prolactin and its receptor: From animal models to pituitary pathophysiology].
    3. Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring.
      Title: Dietary interventions in mice affect oxidative stress and gene expression of the Prlr and Esr1 in the adipose tissue and hypothalamus of dams and their offspring.
    4. The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.
      Title: The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.
    5. Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice.
      Title: Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice.
    6. Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
      Title: Acute effects of prolactin on hypothalamic prolactin receptor expressing neurones in the mouse.
    7. The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
      Title: The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females.
    8. Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
      Title: Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling.
    9. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
      Title: Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression.
    10. Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.
      Title: Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.
    Submit: New GeneRIF Correction See all GeneRIFs (48)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables prolactin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prolactin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prolactin receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables prolactin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of Janus kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of Janus kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lactation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lactation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland alveolus development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mammary gland epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prolactin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within prostate gland growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prolactin receptor
    Names
    PRL-R
    prolactin receptor related sequence 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253781.1 → NP_001240710.1  prolactin receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001240710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon and an alternate 3' exon including the coding region and UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK052679, AK054381, BP761592
      Consensus CDS
      CCDS56976.1
      UniProtKB/TrEMBL
      G3UVW6, Q8C7G1
      Related
      ENSMUSP00000121280.2, ENSMUST00000128921.8
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001253782.2 → NP_001240711.1  prolactin receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001240711.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK052679, M22958
      Consensus CDS
      CCDS56975.1
      UniProtKB/TrEMBL
      Q8C7G1
      Related
      ENSMUSP00000122209.2, ENSMUST00000128450.8
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. NM_011169.5 → NP_035299.4  prolactin receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_035299.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI527408, AK052679, AK054551, AK077980, AK083198, AK087727, AK087749, AK165113, BG087509, DV053280
      Consensus CDS
      CCDS27377.1
      UniProtKB/Swiss-Prot
      P15212, P15213, Q08501, Q62099
      UniProtKB/TrEMBL
      Q99JZ1
      Related
      ENSMUSP00000122219.2, ENSMUST00000124470.8
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      10177324..10349276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248425.1 → XP_030104285.1  prolactin receptor isoform X2

      UniProtKB/TrEMBL
      G3UVW6, Q8C7G1
      Related
      ENSMUSP00000121935.2, ENSMUST00000137867.8
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_006520035.1 → XP_006520098.1  prolactin receptor isoform X1

      See identical proteins and their annotated locations for XP_006520098.1

      UniProtKB/Swiss-Prot
      P15212, P15213, Q08501, Q62099
      UniProtKB/TrEMBL
      Q99JZ1
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_006520034.3 → XP_006520097.1  prolactin receptor isoform X1

      See identical proteins and their annotated locations for XP_006520097.1

      UniProtKB/Swiss-Prot
      P15212, P15213, Q08501, Q62099
      UniProtKB/TrEMBL
      Q99JZ1
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_006520038.2 → XP_006520101.1  prolactin receptor isoform X3

      See identical proteins and their annotated locations for XP_006520101.1

      UniProtKB/TrEMBL
      Q8C7G1
      Related
      ENSMUSP00000118355.2, ENSMUST00000148257.8
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. XM_036159267.1 → XP_036015160.1  prolactin receptor isoform X2

      UniProtKB/TrEMBL
      G3UVW6, Q8C7G1
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    6. XM_006520036.1 → XP_006520099.1  prolactin receptor isoform X1

      See identical proteins and their annotated locations for XP_006520099.1

      UniProtKB/Swiss-Prot
      P15212, P15213, Q08501, Q62099
      UniProtKB/TrEMBL
      Q99JZ1
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    7. XM_006520037.4 → XP_006520100.1  prolactin receptor isoform X1

      See identical proteins and their annotated locations for XP_006520100.1

      UniProtKB/Swiss-Prot
      P15212, P15213, Q08501, Q62099
      UniProtKB/TrEMBL
      Q99JZ1
      Conserved Domains (2) summary
      cd00063
      Location:122 → 219
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:18 → 115
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. XR_383824.4 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_045590.1: Suppressed sequence

      Description
      NR_045590.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    2. NR_045591.1: Suppressed sequence

      Description
      NR_045591.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.

    3. NR_045592.1: Suppressed sequence

      Description
      NR_045592.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08501.1 GenPept UniProtKB/Swiss-Prot:Q08501

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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