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    TPO thyroid peroxidase [ Canis lupus familiaris (dog) ]

    Gene ID: 403521, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TPOprovided by VGNC
    Official Full Name
    thyroid peroxidaseprovided by VGNC
    Primary source
    VGNC:VGNC:47746
    See related
    Ensembl:ENSCAFG00845017327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 17
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (830903..866744)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (760899..796526)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (775279..810948)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (755185..790848)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (775417..811064)

    Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119869787 Neighboring gene syntrophin gamma 2 Neighboring gene uncharacterized LOC119869718 Neighboring gene peroxidasin Neighboring gene myelin transcription factor 1 like Neighboring gene uncharacterized LOC111090456

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A thyroid peroxidase (TPO) mutation in dogs reveals a canid-specific gene structure. Fyfe JC, et al. Mamm Genome, 2013 Apr. PMID 23223904
    2. Congenital hypothyroidism with goiter in toy fox terriers. Fyfe JC, et al. J Vet Intern Med, 2003 Jan-Feb. PMID 12564727

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iodide peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyroid peroxidase
    NP_001003009.2
    XP_038546350.1
    XP_038546351.1
    XP_038546352.1
    XP_038546353.1
    XP_038546354.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003009.2 → NP_001003009.2  thyroid peroxidase precursor

      See identical proteins and their annotated locations for NP_001003009.2

      Status: PROVISIONAL

      Source sequence(s)
      AY094504
      UniProtKB/TrEMBL
      A0A8C0YSV9, A0A8I3PAJ8
      Related
      ENSCAFP00845024091.1, ENSCAFT00845030712.1
      Conserved Domains (4) summary
      cd00033
      Location:751 → 804
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:179 → 743
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:805 → 848
      EGF_CA; Calcium-binding EGF-like domain
      pfam03098
      Location:163 → 708
      An_peroxidase; Animal haem peroxidase

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051821.1 Reference ROS_Cfam_1.0

      Range
      830903..866744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038690423.1 → XP_038546351.1  thyroid peroxidase isoform X2

      UniProtKB/TrEMBL
      A0A8C0YSV9, A0A8I3PAJ8
      Conserved Domains (3) summary
      cd00033
      Location:707 → 760
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:761 → 804
      EGF_CA; Calcium-binding EGF-like domain
      cl14561
      Location:179 → 699
      An_peroxidase_like; Animal heme peroxidases and related proteins

    2. XM_038690426.1 → XP_038546354.1  thyroid peroxidase isoform X4

      UniProtKB/TrEMBL
      A0A8I3NTD0, A0A8P0T3F5
      Related
      ENSCAFP00845024173.1, ENSCAFT00845030838.1
      Conserved Domains (3) summary
      cd00033
      Location:581 → 634
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:635 → 678
      EGF_CA; Calcium-binding EGF-like domain
      cl14561
      Location:13 → 573
      An_peroxidase_like; Animal heme peroxidases and related proteins

    3. XM_038690422.1 → XP_038546350.1  thyroid peroxidase isoform X1

      UniProtKB/TrEMBL
      A0A8C0YSV9, A0A8I3PAJ8
      Conserved Domains (3) summary
      cd00033
      Location:733 → 786
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:161 → 725
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:787 → 830
      EGF_CA; Calcium-binding EGF-like domain

    4. XM_038690424.1 → XP_038546352.1  thyroid peroxidase isoform X3

      UniProtKB/TrEMBL
      A0A8C0YSV9, A0A8I3PAJ8
      Conserved Domains (3) summary
      cd00033
      Location:646 → 699
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:74 → 638
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:700 → 743
      EGF_CA; Calcium-binding EGF-like domain

    5. XM_038690425.1 → XP_038546353.1  thyroid peroxidase isoform X3

      UniProtKB/TrEMBL
      A0A8C0YSV9, A0A8I3PAJ8
      Conserved Domains (3) summary
      cd00033
      Location:646 → 699
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:74 → 638
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      smart00179
      Location:700 → 743
      EGF_CA; Calcium-binding EGF-like domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049277.1 Alternate UMICH_Zoey_3.1

      Range
      755185..790848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

      Range
      775417..811064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

      Range
      775279..810948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      760899..796526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8HYB7.2 GenPept UniProtKB/Swiss-Prot:Q8HYB7

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