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    ERVK-19 endogenous retrovirus group K member 19, envelope [ Homo sapiens (human) ]

    Gene ID: 105376906, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERVK-19provided by HGNC
    Official Full Name
    endogenous retrovirus group K member 19, envelopeprovided by HGNC
    Primary source
    HGNC:HGNC:39026
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR; P1.8; envK3; Protease; Proteinase; polymerase; HERV-K(C19)
    Expression
    Ubiquitous expression in duodenum (RPKM 2.7), small intestine (RPKM 2.4) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ERVK-19 in Genome Data Viewer
    Location:
    19q11

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chromosomal assignment of human endogenous retrovirus K (HERV-K) env open reading frames. Mayer J, et al. Cytogenet Cell Genet, 1997. PMID 9533039
    2. Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses. Zsíros J, et al. J Gen Virol, 1998 Jan. PMID 9460924
    3. Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells. Tönjes RR, et al. J Virol, 1997 Apr. PMID 9060628, Free PMC Article
    4. Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K. Tönjes RR, et al. J Virol, 1999 Nov. PMID 10516026, Free PMC Article
    5. Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas. Sauter M, et al. J Virol, 1995 Jan. PMID 7983737, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    See variants in ClinVar

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Other Names

    • Endogenous retrovirus group K member 19 Gag polyprotein
    • Endogenous retrovirus group K member 19 Pro protein
    • Envelope polyprotein
    • Gag polyprotein
    • HERV-K(C19) Gag protein
    • HERV-K(C19) Pro protein
    • HERV-K_19q11 provirus ancestral Env polyprotein
    • HERV-K_19q11 provirus ancestral Gag polyprotein
    • HERV-K_19q11 provirus ancestral Pol protein
    • HERV-K_19q12 provirus ancestral Pro protein
    • endogenous retrovirus group K member 19 Pol protein
    • endogenous retrovirus group K, member 19

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in syncytium formation by plasma membrane fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O71037.2 GenPept UniProtKB/Swiss-Prot:O71037
    P63120.1 GenPept UniProtKB/Swiss-Prot:P63120
    Q9YNA8.3 GenPept UniProtKB/Swiss-Prot:Q9YNA8

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